DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYLD and Cyld

DIOPT Version :10

Sequence 1:NP_609371.2 Gene:CYLD / 34380 FlyBaseID:FBgn0032210 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_001121642.1 Gene:Cyld / 74256 MGIID:1921506 Length:955 Species:Mus musculus


Alignment Length:615 Identity:249/615 - (40%)
Similarity:358/615 - (58%) Gaps:54/615 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 NHSAVDNQ--------HLEDV---------DLADILGTNWPKRAGPAAMILNNKSKTD------- 99
            |.|:||:|        ::::|         :::...|.:.|....|:...|:::::..       
Mouse   359 NGSSVDSQQSKSKNPWYIDEVAEDPAKSLTEMSSDFGHSSPPPQPPSMNSLSSENRFHSLPFSLT 423

  Fly   100 --PSNSVDLILKPASPILKIEPEEPLRFTIADYQPLIEIPGTE--LAIGSLVEV-SNPGVCEDLY 159
              |:.:..:...|.|..::....|.....:.:..||....|..  |.:|||.|| .||    ..|
Mouse   424 KMPNTNGSMAHSPLSLSVQSVMGELNSTPVQESPPLPISSGNAHGLEVGSLAEVKENP----PFY 484

  Fly   160 GVVRWIGIPPGPQKNVLVGIEVEDESNLKNVVASDGRHNGVRLFTCHDGRAIFVPANRCTADRRF 224
            ||:||||.||| ..:||.|:|:|||.    ...:||...|.|.|||...:|:||....|..|.||
Mouse   485 GVIRWIGQPPG-LSDVLAGLELEDEC----AGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRF 544

  Fly   225 ADVDNSISANRVSSNHAKKFGVADCPAIYGSIPPLQIHNSDELASICGKFKGIQGHHNSCYLDAT 289
            |.:..  .:|::...::..||......:..:.||..  ..:.|..:.||.||||||:||||||:|
Mouse   545 ASLQP--VSNQIERCNSLAFGGYLSEVVEENTPPKM--EKEGLEIMIGKKKGIQGHYNSCYLDST 605

  Fly   290 LFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVFVRSDRVMKLRELLDQLSS 354
            ||.:|.|:|..|::|.|.....||..|||.|::||.|||||||...:|.:.::||||::|:::.:
Mouse   606 LFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEA 670

  Fly   355 VSGLTCEEKDPEEFLNSLLSQIMRVEPFLKLSSG----QDSYFYQLFVEKDEKLTLPSVQQLFEQ 415
            .||.|.||||||||||.|...|:||||.||:.|.    ||..|||:|:||:||:.:|::|||.|.
Mouse   671 ASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKVQDCNFYQIFMEKNEKVGVPTIQQLLEW 735

  Fly   416 SFHSSDIKLKEVPSCFIIQMPRFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECRD 480
            ||.:|::|..|.|||.|||||||||::|::.:|.||..|::||::|::||||.:||.||.||||:
Mouse   736 SFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRE 800

  Fly   481 CFGSLQAGSGLECTAFCPKCLKTFHSHIKRTNHVSKKIYSPKEFKIMA-EHMVVPRLYMELFAVV 544
            |:......:| :...||..|....|.|.:|.||....:..||:..... .|..:|...||||||:
Mouse   801 CYDDPDISAG-KIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVL 864

  Fly   545 CIETSHYVAFVKSGSGPDAPWCFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINET-S 608
            ||||||||||||.|. .|:.|.||||||||.|.|||:|||::|..||:.::|.    .|:.:. |
Mouse   865 CIETSHYVAFVKYGK-DDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLK----MSLEDLHS 924

  Fly   609 TNDKVLPEHAKRIFCDAYMCLYQSTDIMMY 638
            .:.:.:...|:|:.||||||:|||..:.:|
Mouse   925 LDSRRIQGCARRLLCDAYMCMYQSPTMSLY 954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYLDNP_609371.2 CAP_GLY 143..219 CDD:214997 34/76 (45%)
Peptidase_C19N 276..631 CDD:239135 179/360 (50%)
CyldNP_001121642.1 CAP_GLY 127..203 CDD:214997
CAP_GLY 232..>286 CDD:214997
CYLD_phos_site 307..462 CDD:465194 16/102 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 314..353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..412 4/22 (18%)
Interaction with TRAF2. /evidence=ECO:0000250|UniProtKB:Q9NQC7 393..468 11/74 (15%)
Interaction with IKBKG/NEMO. /evidence=ECO:0000250|UniProtKB:Q9NQC7 469..683 98/226 (43%)
CAP_GLY 471..539 CDD:214997 34/76 (45%)
Peptidase_C19N 592..947 CDD:239135 179/360 (50%)
B-box. /evidence=ECO:0000250|UniProtKB:Q9NQC7 780..832 21/52 (40%)
Blue background indicates that the domain is not in the aligned region.

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