DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYLD and cyldl

DIOPT Version :9

Sequence 1:	NP_609371.2	Gene:	CYLD / 34380	FlyBaseID:	FBgn0032210	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_003198851.2	Gene:	cyldl / 561108	ZFINID:	ZDB-GENE-131127-190	Length:	761	Species:	Danio rerio

Alignment Length:	566	Identity:	223/566 - (39%)
Similarity:	320/566 - (56%)	Gaps:	57/566 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 MILNNKSKTDPSNSVDLILKPASPILKIEPEEPL----RFTIADYQPLIEIPGTE-LAIGSLVEV 149
            |:|.:..|.:.......||.|...|:|   ||.|    :...:..|.:.....:| :::||||:.
Zfish   235 MVLISTDKDEEGKQGGEILVPLDCIMK---EELLNTDEKMDTSQNQEMDSASDSEGISVGSLVQY 296

  Fly   150 SNPGVCEDLYGVVRWIG-IPPGPQKNVLVGIEVEDESNLKNVVASDGRHNGVRLFTCHDGRAIFV 213
            ..     :..|:||||| :|...:|:  .|:||...|.:     .||::.|.:.|.|.....:||
Zfish   297 MG-----NKLGIVRWIGYLPDFSEKS--AGLEVVTGSGV-----CDGKYKGKQYFDCDPKSGLFV 349

  Fly   214 PANRCTADRRFADVDNSISANRVSSNHAKKFGVADCPAI---YGSIPPLQIHNSDELASICGKFK 275
            ..:.|..|      |:...||...||     |..|...:   ..::||  |...|....:.|:.|
Zfish   350 KLSVCRPD------DSVSGANENKSN-----GYIDHDGVSVEVENVPP--IRTEDVSQRLIGQNK 401

  Fly   276 GIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVFVRSD 340
            |||||.||||:|:.|||:|:.:||.||:|::...|:|    ..:|.:|...|||||||..||.:.
Zfish   402 GIQGHCNSCYMDSALFSVFSCSSVLDSLLFKSINPED----KTIQDILLKNIVNPLRKQGFVSAR 462

  Fly   341 RVMKLRELLDQLSSVSGLTCEEKDPEEFLNSLLSQIMRVEPFLKL-SSG-----QDSYFYQLFVE 399
            .||.||:.|.:.......|.:||||||||:.::.:|:.::|.|.| .||     |..|:||:|::
Zfish   463 CVMNLRKQLQKREHCPTYTTDEKDPEEFLSLIMQEILFLDPLLSLCQSGSRHKVQSCYYYQIFMD 527

  Fly   400 KDEKLTLPSVQQLFEQSFHSSDIKLKEVPSCFIIQMPRFGKNYKMYPRILPSQVLDVTDIIENSP 464
            .:..|.||:||||.|.||:|:.:||.|||:|.|:.|||.||::||:|:|:||..||:|.::.:||
Zfish   528 YNHHLVLPTVQQLLEHSFYSNSLKLAEVPACLILTMPRSGKSFKMFPKIIPSTELDITGLLADSP 592

  Fly   465 RQCSLCGKLAEYECRDCF-GSLQAGSGLECTAFCPKCLKTFHSHIKRTNHVSKKIYSPKEFKIMA 528
            :||..||.||..||.:|| .:|.:.:|.:  .||.||....|||.:|.:|....::.|:.|. .:
Zfish   593 QQCVSCGLLANEECAECFRDALFSDTGFK--YFCTKCSTQVHSHQQRRHHTPSSLHLPQGFS-YS 654

  Fly   529 EHMVVPRLYMELFAVVCIETSHYVAFVKSGSGPDAPWCFFDSMADRKGEQNGYNIPEITCVPELT 593
            :.:..|...:|||||:||||||||:|||.|. .|..|.||||||||.||.|||||||:...||:.
Zfish   655 DSLTPPPEKLELFAVLCIETSHYVSFVKHGP-RDTDWIFFDSMADRVGESNGYNIPEVRACPEVG 718

  Fly   594 QWLSEEGARSINETSTN-DKVLPEHAKRIFCDAYMCLYQSTDIMMY 638
            |:|....|:..|:.... |.|    |||:|||.||.||||..:.:|
Zfish   719 QYLHMPLAQLANQVPREMDGV----AKRLFCDGYMYLYQSKSMSLY 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYLD	NP_609371.2	CAP_GLY	143..219	CDD:214997	23/76 (30%)
CYLD	NP_609371.2	Peptidase_C19N	276..631	CDD:239135	168/362 (46%)
cyldl	XP_003198851.2	CAP_GLY	110..179	CDD:279625
		CAP_GLY	291..352	CDD:279625	23/72 (32%)
		Peptidase_C19	402..753	CDD:271592	168/362 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594441
Domainoid	1	1.000	63	1.000	Domainoid score	I10254
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119442at2759
OrthoFinder	1	1.000	-	-		FOG0003008
OrthoInspector	1	1.000	-	-		otm25651
orthoMCL	1	0.900	-	-		OOG6_103005
Panther	1	1.100	-	-	LDO	PTHR11830
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.850