Protein Alignment CYLD and Cyld

DIOPT Version :9

• Sequence 1: NP_609371.2
• Gene: CYLD / 34380
• FlyBaseID: FBgn0032210
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: XP_038953724.1
• Gene: Cyld / 312937
• RGDID: 1308346
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 616
• Identity: 247/616 - (40%)
• Similarity: 358/616 - (58%)
• Gaps: 55/616 - (8%)

  Fly    59 NHSAVDNQ---------HLEDV---------DLADILGTNWPKRAGPAAMILNNKSKTD------ 99
            |.|:||:|         ::::|         :::...|.:.|....|:...|:::::..
  Rat   359 NGSSVDSQQQSKSKNPWYIDEVAEDPAKSLTEMSSDFGHSSPPPQPPSMNSLSSENRFHSLPFSL 423

  Fly   100 ---PSNSVDLILKPASPILKIEPEEPLRFTIADYQPLIEIPGTE--LAIGSLVEV-SNPGVCEDL 158
               |:.:..:...|.|..::....|.....:.:..|:....|..  |.:|||.|| .||    ..
  Rat   424 TKMPNTNGSMAHSPLSLSVQSVMGELNSTPVQESPPMPSSSGNAHGLEVGSLAEVKENP----PF 484

  Fly   159 YGVVRWIGIPPGPQKNVLVGIEVEDESNLKNVVASDGRHNGVRLFTCHDGRAIFVPANRCTADRR 223
            |||:||||.||| ..:||.|:|:|||.    ...:||...|.|.|||...:|:||....|..|.|
  Rat   485 YGVIRWIGQPPG-LSDVLAGLELEDEC----AGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSR 544

  Fly   224 FADVDNSISANRVSSNHAKKFGVADCPAIYGSIPPLQIHNSDELASICGKFKGIQGHHNSCYLDA 288
            ||.:..  .:|::...::..||......:..:.||..  ..:.|..:.||.||||||:||||||:
  Rat   545 FASLQP--VSNQIERCNSLAFGGYLSEVVEENTPPKM--EKEGLEIMIGKKKGIQGHYNSCYLDS 605

  Fly   289 TLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVFVRSDRVMKLRELLDQLS 353
            |||.:|.|:|..|::|.|.....|:..|||.|::||.|||||||...:|.:.::||||::|:::.
  Rat   606 TLFCLFAFSSALDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVE 670

  Fly   354 SVSGLTCEEKDPEEFLNSLLSQIMRVEPFLKLSSG----QDSYFYQLFVEKDEKLTLPSVQQLFE 414
            :.||.|.||||||||||.|...|:||||.||:.|.    ||..|||:|:||:||:.:|::|||.|
  Rat   671 AASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKVQDCNFYQIFMEKNEKVGVPTIQQLLE 735

  Fly   415 QSFHSSDIKLKEVPSCFIIQMPRFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECR 479
            .||.:|::|..|.|||.|||||||||::|::.:|.||..|::||::|::||||.:||.||.||||
  Rat   736 WSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECR 800

  Fly   480 DCFGSLQAGSGLECTAFCPKCLKTFHSHIKRTNHVSKKIYSPKEFKIMA-EHMVVPRLYMELFAV 543
            :|:......:| :...||..|....|.|.:|.||....:..||:..... .|..:|...||||||
  Rat   801 ECYDDPDISAG-KIKQFCKTCSTQVHLHPRRLNHTYHPVSLPKDLPDWDWRHGCIPCQKMELFAV 864

  Fly   544 VCIETSHYVAFVKSGSGPDAPWCFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINET- 607
            :||||||||||||.|. .|:.|.||||||||.|.|||:|||::|..||:.::|.    .|:.:.
  Rat   865 LCIETSHYVAFVKYGK-DDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLK----MSLEDLH 924

  Fly   608 STNDKVLPEHAKRIFCDAYMCLYQSTDIMMY 638
            |.:.:.:...|:|:.||||||:|||..:.:|
  Rat   925 SLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYLD	NP_609371.2	CAP_GLY	143..219	CDD:214997	34/76 (45%)
		Peptidase_C19N	276..631	CDD:239135	178/360 (49%)
Cyld	XP_038953724.1	CAP_GLY	127..203	CDD:214997
		CAP_GLY	232..>286	CDD:214997
		CYLD_phos_site	307..471	CDD:406904	16/111 (14%)
		CAP_GLY	472..540	CDD:214997	34/76 (45%)
		Peptidase_C19N	593..948	CDD:239135	178/360 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352502
Domainoid	1	1.000	305	1.000	Domainoid score	I1316
eggNOG	1	0.900	-	-		E1_KOG3556
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9069
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119442at2759
OrthoFinder	1	1.000	-	-		FOG0003008
OrthoInspector	1	1.000	-	-		oto96104
orthoMCL	1	0.900	-	-		OOG6_103005
Panther	1	1.100	-	-	O	PTHR11830
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3348
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800