DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYLD and si:cabz01101003.1

DIOPT Version :9

Sequence 1:	NP_609371.2	Gene:	CYLD / 34380	FlyBaseID:	FBgn0032210	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_002662639.4	Gene:	si:cabz01101003.1 / 100333117	ZFINID:	ZDB-GENE-160728-148	Length:	575	Species:	Danio rerio

Alignment Length:	600	Identity:	223/600 - (37%)
Similarity:	311/600 - (51%)	Gaps:	77/600 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 MILNNKSKTDPSNSVDL------ILKPA---SPILKIEPEEPLRFTIADYQP-------LIEIPG 138
            |:|:.|....|.:.:.|      ..|||   .|:...:|:.......:|..|       |...|.
Zfish     1 MLLSAKQALQPPSKIALRPPPLTTPKPALIPPPVPPNKPQATPTTPPSDQLPSSNGFHNLPSPPI 65

  Fly   139 TE--------LAIGSLVEVSNPGVCEDLYGVVRWIGIPPGPQKNVLVGIEVEDESNLKNVVASDG 195
            ||        |.:||:|||::|    .|:||:||||...|..:.| .|||::.|.:    .|:||
Zfish    66 TEQRAELNSWLEVGSMVEVNDP----PLFGVIRWIGQISGIPEPV-AGIELDQELS----AATDG 121

  Fly   196 RHNGVRLFTCHDGRAIFVPANRCTADRRFADVDNSISANRVSSNHAKKFGVADCPAIYGSIPPLQ 260
            .:.|.|.|.|...:.:||....|..|.||...:.||  |:|...::..|.......:....||
Zfish   122 SYLGERHFRCPANKGLFVKLRNCRRDSRFPAPEPSI--NQVDRCNSIAFANWSSKRVDEHTPP-- 182

  Fly   261 IHNSDELASICGKFKGIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRD 325
            :...|......|..||||||.|||||||||||||:.:|.||.:|:...|.|...:....|.:||.
Zfish   183 VSGPDARLMYEGFKKGIQGHLNSCYLDATLFSMFSCSSSFDWLLFWPTGAQLSPHCKSAQDLLRC 247

  Fly   326 EIVNPLRKNVFVRSDRVMKLRELLDQLSSVSGLTCEEKDPEEFLNSLLSQIMRVEPFLKLSS--- 387
            |||||||:..:|.:.:.|.||:||...::.||.|.||||||||||.|. .::||||.||:.|
Zfish   248 EIVNPLRRFGYVCASKTMALRKLLKAETADSGFTNEEKDPEEFLNQLF-LLLRVEPLLKIRSVSQ 311

  Fly   388 -GQDSYFYQLFVEKDEKLTLP--------------------SVQQLFEQSFHSSDIKLKEVPSCF 431
             .|:.:.||||.........|                    |||.|.|.||..:.:|..|.|||.
Zfish   312 QAQECFLYQLFPPSTSACPSPGSAVPLSPLASPSAGLQRVSSVQALLESSFIHAGLKFTEAPSCL 376

  Fly   432 IIQMPRFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECRDCFGSLQAGSGLECTAF 496
            .:.||||||.:||:..||||..||:||:::.:.||||:|..:|::||..|:..:....| :...:
Zfish   377 PLLMPRFGKEFKMFDAILPSLTLDITDLLDETLRQCSICQSVAQWECLQCYDDVDITPG-QMKQY 440

  Fly   497 CPKCLKTFHSHIKRTNHVSKKIYSPKEFKIMAEHMVVP--RLYMELFAVVCIETSHYVAFVKSGS 559
            |..|....|:|.:|..|....:..|:.    :....||  |..|.||||.||||||||:|||  .
Zfish   441 CNTCNTQVHTHKRRQTHTPSAVRGPQG----SWEGPVPGVRQIMHLFAVTCIETSHYVSFVK--H 499

  Fly   560 GPD-APWCFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINETSTNDKVLPEHAKRIFC 623
            ||: :.|.||||||||:|.:||:|:|:::..|||::..|    .|::|....| .|....:|:.|
Zfish   500 GPEHSDWLFFDSMADREGGENGFNVPQVSWCPELSELFS----LSVDEVCRLD-ALRGPVRRLLC 559

  Fly   624 DAYMCLYQSTDIMMY 638
            |:|||||....:.:|
Zfish   560 DSYMCLYHCPQLTLY 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYLD	NP_609371.2	CAP_GLY	143..219	CDD:214997	28/75 (37%)
CYLD	NP_609371.2	Peptidase_C19N	276..631	CDD:239135	162/381 (43%)
si:cabz01101003.1	XP_002662639.4	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119442at2759
OrthoFinder	1	1.000	-	-		FOG0003008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850