Protein Alignment CYLD and cyld

DIOPT Version :9

• Sequence 1: NP_609371.2
• Gene: CYLD / 34380
• FlyBaseID: FBgn0032210
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: XP_012816047.2
• Gene: cyld / 100144739
• XenbaseID: XB-GENE-1032935
• Length: 975
• Species: Xenopus tropicalis
• Alignment Length: 659
• Identity: 260/659 - (39%)
• Similarity: 368/659 - (55%)
• Gaps: 85/659 - (12%)

  Fly    22 GDSLENYELSNESEHKTHVYPKKIPNR----KNGILKN-------------TDANHSAV------ 63
            |.|:|.   .::|:.|...|..:...|    .:|:.:|             ||::|:|.
 Frog   359 GSSVET---QHQSKSKNTWYMDEARERSSRGSSGVQENSRCETVEDSAKSLTDSSHAAFGHCSPP 420

  Fly    64 -----------DNQ-HLEDVDLADILGTNWPKRAGPAAMILNNKSKTDPSNSVDLILKPASPILK 116
                       :|: |.....|:.:..||  ...|...:.|:.:|.....|:|.|
 Frog   421 LQPSASSSSPGENRFHSLPFSLSKMSSTN--GTMGHTPLSLSVQSVIGELNNVSL---------- 473

  Fly   117 IEPEEPLRFTIADYQPLIEIPGTELAIGSLVEV-SNPGVCEDLYGVVRWIGIPPGPQKNVLVGIE 180
              .:.|.|||     .:..:.|.|  :|||.|| .||    ..|||:||||.|.|..: :|.|:|
 Frog   474 --QDIPPRFT-----HISNLHGLE--VGSLAEVKENP----PFYGVIRWIGQPAGVNE-MLAGLE 524

  Fly   181 VEDESNLKNVVASDGRHNGVRLFTCHDGRAIFVPANRCTADRRFADVDNSISANRVSSNHAKKFG 245
            :|||.    ...:||...|.|.|||...:|:||....|..|.|||.:..  .:|::...::..||
 Frog   525 LEDEC----AGCTDGTFKGTRYFTCAPKKALFVKLKSCRPDSRFASLQP--VSNQIERCNSLAFG 583

  Fly   246 VADCPAIYGSIPPLQIHNSDELASICGKFKGIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGP 310
            ......:.|:.||..  ..:.|..:.||.||||||:||||||:|||.:|:|:||.||:|.|....
 Frog   584 GYLSEVVEGNTPPRT--EKEGLEVMIGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDSVLLRPKEK 646

  Fly   311 QDIRNYSEVQKVLRDEIVNPLRKNVFVRSDRVMKLRELLDQLSSVSGLTCEEKDPEEFLNSLLSQ 375
            .|:..|||.|.:||.|||||||...:|.:.::||||::|:::.:.||.|.||||||||||.|...
 Frog   647 TDVEYYSETQALLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHH 711

  Fly   376 IMRVEPFLKLSSG----QDSYFYQLFVEKDEKLTLPSVQQLFEQSFHSSDIKLKEVPSCFIIQMP 436
            |:||:|.||:.|.    ||.||||:|::|:|.:.:|::|||.|.||.:|.:|..|.|||.|:|||
 Frog   712 ILRVDPLLKIRSAGQKVQDCYFYQIFMDKNENVGVPTIQQLLEWSFINSSLKFAEAPSCLIVQMP 776

  Fly   437 RFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECRDCFGSLQAGSGLECTAFCPKCL 501
            ||||::||:.:|.||..|::||::|::||||.:||.||.||||:|:......:| :...||..|.
 Frog   777 RFGKDFKMFNKIFPSLDLNITDLLEDTPRQCRICGGLAMYECRECYDDPDITAG-KIKQFCKICN 840

  Fly   502 KTFHSHIKRTNHVSKKIYSPKEFKIMA-EHMVVPRLYMELFAVVCIETSHYVAFVKSGSGPDAPW 565
            ...|.|.||.:|....:..|||..... .|..:|...|:||||:||||||||||||.|. .|:.|
 Frog   841 TQVHLHPKRQHHKFNPVSLPKELPDWDWRHGCIPYQKMDLFAVLCIETSHYVAFVKYGR-DDSSW 904

  Fly   566 CFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINETSTND-KVLPEHAKRIFCDAYMCL 629
            .||||||||.|.|||:|||::|..||:.::|.    .|:.|....| :.:...|:|:.||||||:
 Frog   905 VFFDSMADRDGGQNGFNIPQVTPCPEVGEYLK----MSLEELHALDSRNIQGCARRLLCDAYMCM 965

  Fly   630 YQSTDIMMY 638
            |||..:.:|
 Frog   966 YQSPTMSLY 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYLD	NP_609371.2	CAP_GLY	143..219	CDD:214997	32/76 (42%)
		Peptidase_C19N	276..631	CDD:239135	179/360 (50%)
cyld	XP_012816047.2	CAP_GLY	134..204	CDD:214997
		CAP_GLY	233..>287	CDD:214997
		CYLD_phos_site	305..490	CDD:406904	29/152 (19%)
		CAP_GLY	491..559	CDD:214997	32/76 (42%)
		Peptidase_C19N	612..967	CDD:239135	179/360 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1377
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9069
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2002
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119442at2759
OrthoFinder	1	1.000	-	-		FOG0003008
OrthoInspector	1	1.000	-	-		otm47862
Panther	1	1.100	-	-	O	PTHR11830
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070