Protein Alignment Hand and HAND2

DIOPT Version :9

• Sequence 1: NP_609370.2
• Gene: Hand / 34379
• FlyBaseID: FBgn0032209
• Length: 174
• Species: Drosophila melanogaster
• Sequence 2: NP_068808.1
• Gene: HAND2 / 9464
• HGNCID: 4808
• Length: 217
• Species: Homo sapiens
• Alignment Length: 139
• Identity: 76/139 - (54%)
• Similarity: 88/139 - (63%)
• Gaps: 14/139 - (10%)

  Fly    44 SHLGYVP-------TSNTRIVKKRNTANKKERRRTQSINNAFSYLREKIPNVPTDTKLSKIKTLK 101
            ||.|.||       ....|.||:|.|||:||||||||||:||:.|||.|||||.||||||||||:
Human    78 SHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLR 142

  Fly   102 LAILYINYLVNVLDGDLDPKG---GFRAELKPVSRKICSEKK---HCLKSEIQNVPLSTKGRTGW 160
            ||..||.||:::|..| |..|   .|:||:|....|....||   ..|||.:.:....|||||||
Human   143 LATSYIAYLMDLLAKD-DQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGW 206

  Fly   161 PQDVWASEL 169
            ||.|||.||
Human   207 PQHVWALEL 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hand	NP_609370.2	HLH	59..110	CDD:278439	38/50 (76%)
HAND2	NP_068808.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..116		20/37 (54%)
		bHLH_TS_HAND2	100..161	CDD:381477	43/61 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149586
Domainoid	1	1.000	80	1.000	Domainoid score	I8620
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4727
Isobase	1	0.950	-	0	Normalized mean entropy	S4541
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1449816at2759
OrthoFinder	1	1.000	-	-		FOG0005250
OrthoInspector	1	1.000	-	-		otm41218
orthoMCL	1	0.900	-	-		OOG6_108293
Panther	1	1.100	-	-	O	PTHR23349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5507
SonicParanoid	1	1.000	-	-		X3772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740