Protein Alignment Hand and HAND1

DIOPT Version :9

• Sequence 1: NP_609370.2
• Gene: Hand / 34379
• FlyBaseID: FBgn0032209
• Length: 174
• Species: Drosophila melanogaster
• Sequence 2: NP_004812.1
• Gene: HAND1 / 9421
• HGNCID: 4807
• Length: 215
• Species: Homo sapiens
• Alignment Length: 124
• Identity: 64/124 - (51%)
• Similarity: 81/124 - (65%)
• Gaps: 10/124 - (8%)

  Fly    55 RIVKKRNTANKKERRRTQSINNAFSYLREKIPNVPTDTKLSKIKTLKLAILYINYLVNVLDGDL- 118
            |:.:::.:..|||||||:|||:||:.|||.|||||.||||||||||:||..||.||::||..|.
Human    91 RLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQ 155

  Fly   119 --DPKGGFRAELKPVSRKICSEKKHCLKSE------IQNVPLSTKGRTGWPQDVWASEL 169
              ||: .|:||||.......|::|..|:..      :..|....||||||||.|||.||
Human   156 SGDPE-AFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALEL 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hand	NP_609370.2	HLH	59..110	CDD:278439	34/50 (68%)
HAND1	NP_004812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..109		8/17 (47%)
		bHLH_TS_HAND1	94..153	CDD:381522	38/58 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..198		6/31 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149590
Domainoid	1	1.000	80	1.000	Domainoid score	I8620
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3545
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4727
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1449816at2759
OrthoFinder	1	1.000	-	-		FOG0005250
OrthoInspector	1	1.000	-	-		otm41218
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23349
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3772
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860