DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hand and hand2

DIOPT Version :9

Sequence 1:	NP_609370.2	Gene:	Hand / 34379	FlyBaseID:	FBgn0032209	Length:	174	Species:	Drosophila melanogaster
Sequence 2:	NP_571701.3	Gene:	hand2 / 58150	ZFINID:	ZDB-GENE-000511-1	Length:	205	Species:	Danio rerio

Alignment Length:	137	Identity:	76/137 - (55%)
Similarity:	88/137 - (64%)	Gaps:	12/137 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SHLGYVPTSNT-----RIVKKRNTANKKERRRTQSINNAFSYLREKIPNVPTDTKLSKIKTLKLA 103
            ||.|.||.:..     |.||:|.|||:||||||||||:||:.|||.|||||.||||||||||:||
Zfish    68 SHYGGVPGAGAVGMGPRTVKRRPTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLA 132

  Fly   104 ILYINYLVNVLDGDLDPKG---GFRAELKPVSRKICSEKKH---CLKSEIQNVPLSTKGRTGWPQ 162
            ..||.||:::||.| :..|   .|:||.|....|....||.   .|||...:....|||||||||
Zfish   133 TSYIAYLMDILDKD-EQNGETEAFKAEFKKTDAKEERRKKEMNDVLKSSGSSNDKKTKGRTGWPQ 196

  Fly   163 DVWASEL 169
            .|||.||
Zfish   197 HVWALEL 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hand	NP_609370.2	HLH	59..110	CDD:278439	38/50 (76%)
hand2	NP_571701.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..103		14/26 (54%)
		HLH	88..139	CDD:278439	38/50 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..194		13/35 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583736
Domainoid	1	1.000	79	1.000	Domainoid score	I8681
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4702
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1449816at2759
OrthoFinder	1	1.000	-	-		FOG0005250
OrthoInspector	1	1.000	-	-		oto39144
orthoMCL	1	0.900	-	-		OOG6_108293
Panther	1	1.100	-	-	O	PTHR23349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5507
SonicParanoid	1	1.000	-	-		X3772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790