DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and AREL1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	1144	Identity:	210/1144 - (18%)
Similarity:	331/1144 - (28%)	Gaps:	499/1144 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly  1668 PVPCTNVPVG----------GKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQ 1722
            |.| .:.|||          ..:.|..|.::...|:|     |....|..:.:.:..:|:|
Human    89 PFP-AHRPVGLRVHISHVELAVEIPVTQEVLQEPNSN-----VVKVAFTVRKAGRYEITVK---- 143

  Fly  1723 PNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLL-------ETFA 1780
                          :...||:......|..|.:.      |||.:::..|...|       .|..
Human   144 --------------LGGLNVAYSPYYKIFQPGMV------VPSKTKIVCHFSTLVLTCGQPHTLQ 188

  Fly  1781 AIARRRTSQGTN----IQDNQIMNAEANVNEHG--DQNASGSFLGHSVTS-------LVKLALSS 1832
            .:.|......||    ::|..  |...:::|.|  ::.::|.....||||       .::|.|.|
Human   189 IVPRDEYDNPTNNSMSLRDEH--NYTLSIHELGPQEEESTGVSFEKSVTSNRQTFQVFLRLTLHS 251

  Fly  1833 N--FHSGLLSTAQSYPSLSSNNSE-----------NIAPSNPSNTSA----------GQQSASTI 1874
            .  ||:.:     ||.:...||.|           ||...|.|.:..          ....:||.
Human   252 RGCFHACI-----SYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTP 311

  Fly  1875 NHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQV 1939
            .|...|.:||               |.|.|:...|.:|||...|.:..|              :|
Human   312 WHLPPMHMTS---------------SQRRPSTAVDEEDEDSPSECHTPE--------------KV 347

  Fly  1940 MVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPL 2004
            ...:.:..::..:                 :|.:|..:..:||
Human   348 KKPKKVYCYVSPK-----------------QFSVKEFYLKIIP---------------------- 373

  Fly  2005 GAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDK 2069
                                                        |.::                .
Human   374 --------------------------------------------WRLY----------------T 378

  Fly  2070 FRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCS 2134
            ||             |.|..:                     .|.|.|: |:|
Human   379 FR-------------VCPGTK---------------------FSYLGPD-PVH------------ 396

  Fly  2135 VDDVLELLTQI--NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNW 2197
                 :|||.:  :|: |..::...||..                          :||:..:.:.
Human   397 -----KLLTLVVDDGI-QPPVELSCKERN--------------------------ILAATFIRSL 429

  Fly  2198 CENLNQSCPF-----LFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEF 2257
            .:|:..|..|     .|..|.||::..     ...|.|.|:..|...:|
Human   430 HKNIGGSETFQDKVNFFQRELRQVHMK-----RPHSKVTLKVSRHALLE---------------- 473

  Fly  2258 RIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQR 2321
                   ..:|..||..:..|:..           .||.|.|||.... ||..|::.|:
Human   474 -------SSLKATRNFSISDWSKN-----------FEVVFQDEEALDWGGPRREWFELI------ 514

  Fly  2322 SDLCMWLCDDDLGEDTENS--TQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFF 2384
               |..|.      ||.|.  |:.::.|...|....||      ||.|.         ||.:.|.
Human   515 ---CKALF------DTTNQLFTRFSDNNQALVHPNPNR------PAHLR---------LKMYEFA 555

  Fly  2385 GVFVAKVLQD-------MRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIV 2442
            |..|.|.|.:       .:||....:.||             |.::|..|.:
Human   556 GRLVGKCLYESSLGGAYKQLVRARFTRSF-------------LAQIIGLRMH------------- 594

  Fly  2443 ETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELI 2507
               .|...||                   ||   :|.:.....:|.....|. :.:.||:|:...
Human   595 ---YKYFETD-------------------DP---EFYKSKVCFILNNDMSEM-ELVFAEEKYNKS 633

  Fly  2508 NELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQ 2572
            .:|.                             ...||:..|:...||..|...|..||..:.|.
Human   634 GQLD-----------------------------KVVELMTGGAQTPVTNANKIFYLNLLAQYRLA 669

  Fly  2573 DGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICG------EQFP--------HWS-REDIIS 2622
            ..:.::::.|..|.||:.|...||.|..:|..:::||      ..|.        .|. ||.::.
Human   670 SQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMR 734

  Fly  2623 YTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGV 2687
            :                |..|:.|::.:|....||||||.|.|||||.|.|.|...::.....
Human   735 W----------------FWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTH-- 781

  Fly  2688 GSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE--KGF 2724
            .:.|:.:||.:.|.||.|.:.|.:...|..|..|  :||
Human   782 STLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	13/66 (20%)
		HECTc	2265..2725	CDD:238033	110/487 (23%)
AREL1	NP_001034568.1	Filamin	52..158		15/92 (16%)
		Filamin	56..154	CDD:395505	15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		11/44 (25%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		95/445 (21%)
		HECTc	486..820	CDD:214523	105/473 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900