DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and BAG3

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_004272.2 Gene:BAG3 / 9531 HGNCID:939 Length:575 Species:Homo sapiens


Alignment Length:621 Identity:114/621 - (18%)
Similarity:200/621 - (32%) Gaps:192/621 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1362 GW---IDVK--W----DHGVR----NSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPS 1413
            ||   ||.:  |    ||..|    |..|:.:||..:                   :.|:|..||
Human    25 GWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPKE-------------------TPSSANGPS 70

  Fly  1414 EKGGNTLTSRKSSSTPSLPEATEKNQNP---------EGASNQTVSADNLAWKQTVETIAENVFA 1469
            .:|.....:|:..  |..|:.     .|         |||.|:.|...::..:..::.......|
Human    71 REGSRLPPAREGH--PVYPQL-----RPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEAAA 128

  Fly  1470 SAKTQIIS---------------NQLAMNTSSSREARAKHKESGTNQMHKDNISGP----SPLSR 1515
            :|..:..|               .|:|  .:::.:..|.|              ||    ||.: 
Human   129 AAPQRSQSPLRGMPETTQPDKQCGQVA--AAAAAQPPASH--------------GPERSQSPAA- 176

  Fly  1516 ELEHISDLSAINN--SMPAINSSNVSDLATISENLSLTELSKENICR-VLTPSYKPAESV--TAS 1575
                 ||.|:.::  |:|:...|::.........:|:..:.::|:.| ...||:..|:..  .|.
Human   177 -----SDCSSSSSSASLPSSGRSSLGSHQLPRGYISIPVIHEQNVTRPAAQPSFHQAQKTHYPAQ 236

  Fly  1576 QS--SSHPDV--------------QSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRT 1624
            |.  .:|..|              :::||..:.::..|: .|.:...::..::..|.     :|.
Human   237 QGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASS-REGSPARSSTPLHSPSP-----IRV 295

  Fly  1625 SNIAGCP--PVTQLSTEALEMIDKMRDG---------------VDMIRNMSNSILSTDTFPVPCT 1672
            ..:...|  |:|...|..:...:...:.               :.:||...:|...:...|.|..
Human   296 HTVVDRPQQPMTHRETAPVSQPENKPESKPGPVGPELPPGHIPIQVIRKEVDSKPVSQKPPPPSE 360

  Fly  1673 NVPVGGKKTPKAQALINPDNANQKQI-----IVTSEEFPTKSS-------KKPSVTLKPAQQP-- 1723
            .|.|   |.|.|.....|.:.....:     .|.:||....|:       .||.....|.:.|  
Human   361 KVEV---KVPPAPVPCPPPSPGPSAVPSSPKSVATEERAAPSTAPAEATPPKPGEAEAPPKHPGV 422

  Fly  1724 ---NAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTS----------------EV 1769
               .|:|..|...||.:.|.......:..:.:....|.....:.|..                :|
Human   423 LKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKV 487

  Fly  1770 ATHTGLLETFAAIARRRTS----QGTNIQDNQ----IMNAEANVNEHGDQNASGSFLGHSVTSLV 1826
            .|....||..|.....:..    |.:|::.:|    ||...|...:.|.:||..:...|:.|...
Human   488 QTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAGNAEDPHTETQQP 552

  Fly  1827 KLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPS 1862
            :..          :.|.|.||     |....|.||:
Human   553 EAT----------AAATSNPS-----SMTDTPGNPA 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041
MIB_HERC2 1333..1389 CDD:310955 12/39 (31%)
DamX 1576..>1725 CDD:330571 32/198 (16%)
HECTc 2265..2725 CDD:238033
BAG3NP_004272.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..92 20/92 (22%)
WW 21..53 CDD:197736 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 123..200 17/98 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..421 30/189 (16%)
BAG 421..498 CDD:214591 12/76 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..575 13/57 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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