DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Hecw1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006516872.1	Gene:	Hecw1 / 94253	MGIID:	2444115	Length:	1605	Species:	Mus musculus

Alignment Length:	1771	Identity:	332/1771 - (18%)
Similarity:	564/1771 - (31%)	Gaps:	590/1771 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1305 IGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGT---ITGEIHN-GWID 1365
            |.:|..:.:..|...|..:.....:.:.|......:.|..:|:....:..   :.||:.: .::|
Mouse    64 IPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIGEVSSENFLD 128

  Fly  1366 VKWDHGVRNSYRMGAEGKYDLK--LADCEYLSAFDGNQSMGSASTAAKPS--------------- 1413
            .| :.||..|:|.....|.|..  ..:.|....|.....:..|..|..||
Mouse   129 YK-NRGVNGSHRGQIIWKIDASSYFVESETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKGIG 192

  Fly  1414 ------EKGGNTLTS-----------------------------RKSSSTPSLPEATEKNQNPEG 1443
                  .:|...|.|                             .|.|..|:||     :...|.
Mouse   193 SEETAQSQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALP-----HHGQER 252

  Fly  1444 ASNQTVSADNLAWKQTVETIAENV-FASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNI 1507
            .|....:..|..|:      ||:. |.|..|.::            |...|.|.:.:..:.|..:
Mouse   253 RSTIIGNTVNPIWQ------AEHFSFVSLPTDVL------------EIEVKDKFAKSRPIIKRFL 299

  Fly  1508 SGPS-PLSRELEH--ISD---LSAINNSMPAINSSN--------VSDLATISENLSLT---ELSK 1555
            ...| |:.|.||.  |.|   ...:...:|..:.|.        .|.:....|.:||:   |.|.
Mouse   300 GKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHADDEEISLSAEPESSA 364

  Fly  1556 ENICRVLTPSYKPAESVTAS---QSSSHP---------DVQSSSPRENDIKNISNIEENNKMNAN 1608
            |.           .:|:..|   .|:..|         |.:..||.|.   |..|..||......
Mouse   365 ET-----------QDSIMNSMVGNSNGEPSGDATEFCKDAKPESPSEG---NGVNSSENQNQEHA 415

  Fly  1609 NSVNKISKDLLANLRTSNIAGCP-------PVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDT 1666
            ..|.:.:..:.|. ..||::..|       ...|..|:.....:::.:|:.:..:..:|:|
Mouse   416 GPVEEAAGAMEAR-DGSNVSEAPEEPGELQDPEQHDTQPTLSAEEVAEGLPLDEDSPSSLL---- 475

  Fly  1667 FPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSI-V 1730
               |..|..:|.|...:..    |:|..:::.:...::   :..::..|:.....:|...|.: |
Mouse   476 ---PEENTALGSKVEEETV----PENGAREEEMQKGKD---EEEEEEDVSTLEQGEPGLELRVSV 530

  Fly  1731 DIKEQPISNENVSVPSQMSISVPNLTTTSAS-----EVPSTSEVATHTGLLETFAAIARRRTSQG 1790
            ..|.:|           .|:.|..|.|..||     |.|.|..:..|| ||.:..:..|     |
Mouse   531 RKKSRP-----------CSLPVSELETVIASACGDAETPRTHYIRIHT-LLHSMPSAQR-----G 578

  Fly  1791 TNIQDNQIMNAEANVNEHG-------------------DQNASGSFL---------GH--SVTSL 1825
            :..::...:..|:.:.|..                   |..:.|:.|         ||  |::..
Mouse   579 STTEEEDGLEEESTLKESSEKDGLSEVDTIAADPQSMEDGESDGATLCMAPSDCSGGHFSSLSKG 643

  Fly  1826 VKLALSSNFHSGLLSTAQSYPSLSSNNS------ENIAPS-------NPSNTSAGQQSASTIN-- 1875
            :........|....|.:.|.|...:::|      ...:||       :.|..|:...|:|..|
Mouse   644 IGAGQDGEAHPSTGSESDSSPQQGADHSCEGCDASCCSPSCYSTSCYSSSCYSSSCYSSSCYNGN 708

  Fly  1876 -----HTLTMSLTST------------SSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEE 1923
                 ||...|:.|.            ..:.|..:.|...:|.::|.|        |.:..|...
Mouse   709 NRFASHTRFSSVDSAKISESTVFSSQEDEEEENSAFESVPDSVQSPEL--------DPESTNGAG 765

  Fly  1924 ENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAF---- 1984
            ..:||....|....:           ..|.:|:.:.|.:.|:..:...:...|..:.:|:.
Mouse   766 PWQDELAAPGGNAAR-----------STEGLESPMAGPSNRREGECPILHNSQPISQLPSLRPEH 819

  Fly  1985 -------DPRP----------GRT----NVNQTSDLEISPLGAELP------------------- 2009
                   :|.|          ||.    ::|:|:..: .|..|..|
Mouse   820 HHYPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQ-RPSMAPTPDGMIRSGSVHQMEQLNRRY 883

  Fly  2010 ----------KPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFR----------A 2054
                      :.::..|.:..||...|    |.|.||..:.|.:.|.:...:.|          .
Mouse   884 QNIQRTMATERAEEDSGNQNSEQIPDG----GGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQK 944

  Fly  2055 VQELLQCSQLNKLDKFRKIWEPT-YTIVYREVSPEA--QESTCLES------------EEFPQTP 2104
            |..|||...:    ||  |..|. :|:::...|...  ..||||:.            |.:....
Mouse   945 VTLLLQSPAV----KF--ITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNR 1003

  Fly  2105 D-------------------------------VSSKSGAST-LSPNSPMHIGFNVADNNLCSVDD 2137
            |                               |...|.|:| :.|..|:..|  ...|:|..
Mouse  1004 DLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFIDPRIPLQNG--RLPNHLTH--- 1063

  Fly  2138 VLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQ-DPLVLASN-------AL 2194
             .:.|.::...:..|.....:..|.|:|:..   ...:...::.|.| :.|.||.|       ..
Mouse  1064 -RQHLQRLRSYSAGEASEVSRNRGASLLARP---GHSLIAAIRSQHQHESLPLAYNDKIVAFLRQ 1124

  Fly  2195 PNWCENLNQSCPFLFPFET--RQLYF------------NCT------------------------ 2221
            ||..|.|.:..|.|....|  .::::            :|.
Mouse  1125 PNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLDKLSCDADLVILLSLFEEEIMSYVPLQSAF 1189

  Fly  2222 ----SFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRI----------------GRLKHER 2266
                || :.|...|...|....::|......||.|.|.|.::                |::|
Mouse  1190 HPGYSF-SPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIK--- 1250

  Fly  2267 VKVPRNEDLLMWAMQVMKTHCNR---KSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMW 2327
             .:.|.:.||......:..:..:   ::.|.:.|:.|||... ||:.||:.|::.|:.....
Mouse  1251 -LIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYY--- 1311

  Fly  2328 LCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVL 2392
                .|.|.:.|.|.:.:  ..|:..:|                   ||.|::|.|.|..:...|
Mouse  1312 ----GLFEYSANDTYTVQ--ISPMSAFV-------------------ENYLEWFRFSGRILGLAL 1351

  Fly  2393 QDMRLVDI----PLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDS 2453
            ....|:|.    |.....|:|.|                   |||
Mouse  1352 IHQYLLDAFFTRPFYKGLLKLPC-------------------DLS-------------------- 1377

  Fly  2454 NKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGL 2518
                         :|:.:|...:|.||.|:           |:.|:
Mouse  1378 -------------DLEYLDEEFHQSLQWMK-----------DNNIT------------------- 1399

  Fly  2519 EVSLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAF 2582
                :.|.||||.  :..::| .|:.||...|::..||..|.:.|.|.::.:.::.|:.||.:|.
Mouse  1400 ----DILDLTFTV--NEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEAL 1458

  Fly  2583 SDGFNEVFPLKKLAAFTPSEARMMICGE---QFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVL 2644
            ..||.||...:.::.|...|..::|.|.   ....|...     ||.:.||:......:.|...:
Mouse  1459 LRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNN-----TEYRGGYHDGHLVIRWFWAAV 1518

  Fly  2645 LSMSGDERKAFLQFTTGCSSLPPGGLANLHP----RLTVVRKVDAGVGSYPSVNTCVHYLKLPDY 2705
            ...:.::|...|||.||.||:|..|.|.|..    |...:.|. ..:.|.|..:||.:.|.||.|
Mouse  1519 ERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKW-GKITSLPRAHTCFNRLDLPPY 1582

  Fly  2706 PTEEIMKERLLTATKE 2721
            |:..::.|:||||.:|
Mouse  1583 PSYSMLYEKLLTAVEE 1598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955	13/61 (21%)
		DamX	1576..>1725	CDD:330571	28/164 (17%)
		HECTc	2265..2725	CDD:238033	106/473 (22%)
Hecw1	XP_006516872.1	HECW_N	66..185	CDD:374632	22/119 (18%)
		C2_NEDL1-like	206..342	CDD:176073	28/158 (18%)
		Neuromodulin	378..500	CDD:369001	26/136 (19%)
		WW	829..858	CDD:366073	5/29 (17%)
		HECW1_helix	947..1013	CDD:375862	15/71 (21%)
		WW	1019..1050	CDD:197736	5/30 (17%)
		HECTc	1249..1603	CDD:238033	107/476 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900