DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and TRIP12

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	2368	Identity:	538/2368 - (22%)
Similarity:	856/2368 - (36%)	Gaps:	727/2368 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 SSGSPE-NGNDSSE-NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQ 821
            :|.:|: ..|.:|| :||...::...:.|.||   |.||..|..:.        ..:.|||.|:.
Human    53 NSKAPKVQSNTTSELSRGHLSKRSCSSSSAVI---VPQPEDPDRAN--------TSERQKTGQVP 106

  Fly   822 IHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSAETVLGPDF--ASGWSTAKKKRNKSKTEG---- 880
            ..                   :::||.|.:.|      ||:  .:..|:|||.:....||.
Human   107 KK-------------------DNSRGVKRSAS------PDYNRTNSPSSAKKPKALQHTESPSET 146

  Fly   881 ----QKFQVRNLSREIYNKYFKSAQ-----------------------------IIPRGAVAILT 912
                .|.:.|:|.:|   :..||||                             .:..|:.:..|
Human   147 NKPHSKSKKRHLDQE---QQLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSEST 208

  Fly   913 DI----VKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSG--LVQALVAV 971
            ..    .|..:|:.:....|..|.  :|:||:....|.......|.||......|  :.|.....
Human   209 GAEERSAKPTKLASKSATSAKAGC--STITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQN 271

  Fly   972 LSVNHWETNSPRCKRNKMQKQ------------------RVSVFK-KCILEDNVESATNKPRTKS 1017
            .:......:||..:|:..:|:                  :||:.| |..|..:.:|.|:||
Human   272 KARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKP---- 332

  Fly  1018 TASILIQKLVSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEP 1082
            ..|.|..||.|:.:||:|..    :||..  .|..|::..| :.....|.||  .|.|..|....
Human   333 GPSGLQAKLASLRKSTKKRS----ESPPA--ELPSLRRSTR-QKTTGSCAST--SRRGSGLGKRG 388

  Fly  1083 LATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTCD 1147
            .|                            :..|:.:.|         |.|.....:.|:|...|
Human   389 AA----------------------------EARRQEKMA---------DPESNQEAVNSSAARTD 416

  Fly  1148 ------WVNPAQYGLVQVTS---SEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYI 1203
                  ..:.:..|.|.:|:   ||......|:|:.:|  ::..|..|.       |. .||
Human   417 EAPQGAAASSSVAGAVGMTTSGESESDDSEMGRLQALL--EARGLPPHL-------FG-PLG--- 468

  Fly  1204 IPTAYTLRHAR-GYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTAT---WPINCATDD 1264
             |....|.|.. |.|.|:....||||.:.......|...::...|:..|:..|   :|:.
Human   469 -PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVK----- 527

  Fly  1265 SVWYRHIRIQQNGRNASGQTH------YLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQI 1323
            ||....|.:.|...|.....|      |:    .|...|...|..|                 .|
Human   528 SVVPALITLLQMEHNFDIMNHACRALTYM----MEALPRSSAVVVD-----------------AI 571

  Fly  1324 RAQLKHMTTGARVIRGVDWRWEEQDGCAEGTIT-----GEIHNGWIDVKWDHGVRNSYRMGAEGK 1383
            ...|:.:    :||:.:|        .||..:|     ...|:..|             :.|.|
Human   572 PVFLEKL----QVIQCID--------VAEQALTALEMLSRRHSKAI-------------LQAGG- 610

  Fly  1384 YDLKLADC-EYLSAFDGNQSMGSASTAAK------PSE-----KGGNTLTSRKSSSTPSLPEAT- 1435
                |||| .||..|..|....:.:.||.      |.|     .....||.|.:.......|:|
Human   611 ----LADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTC 671

  Fly  1436 -------EKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAK--------TQIISN--QLAMN 1483
                   :..|:.|....|..|.|.|...|.:..:...:.:|..        :.:.||  .||:.
Human   672 LCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQ 736

  Fly  1484 TSSSREARAKH-----KESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAI---------- 1533
            ......|...|     ..:|:.|...|.:. .||  :||..::.|  |...||.:
Human   737 LMKQNIAETLHFLLCGASNGSCQEQIDLVP-RSP--QELYELTSL--ICELMPCLPKEGIFAVDT 796

  Fly  1534 -----NSSNVSD----------------------LATISENLSLTELSKENICRVLTPSYKPAES 1571
                 |:.|...                      :...:..:...|:|...:.||.|..:...:.
Human   797 MLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQVGEDEISLSTLGRVYTIDFNSMQQ 861

  Fly  1572 VTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLAN-LRT---------SN 1626
            :.....::....:..:|..|  .|.|...|:.|.:|...:.|...:|..: ::|         |:
Human   862 INEDTGTARAIQRKPNPLAN--SNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSS 924

  Fly  1627 IAGCPPVTQLSTEALEMIDKMRDG---VDMIRNMS-----NSILSTDTFPVPCTNVPVGGKKTPK 1683
            .|| |.|......|:..|....|.   .|:::|.:     .|:||:...     .:.||..:  .
Human   925 SAG-PAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDL-----KIVVGALQ--M 981

  Fly  1684 AQALIN--PDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISN-ENVSVP 1745
            |:.|:.  ||                                  :.|:...:|..:.. ::::..
Human   982 AEILMQKLPD----------------------------------IFSVYFRREGVMHQVKHLAES 1012

  Fly  1746 SQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAI---------------------------- 1782
            ..:..|.|...|..:..:.||:.|::.|....|.||.
Human  1013 ESLLTSPPKACTNGSGSMGSTTSVSSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLK 1077

  Fly  1783 -------ARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGH-SVTSLVKLALSSNFH---- 1835
                   ..||........|:::.|...:...  .|:...|||.. :..:..:|:..||.:
Human  1078 RKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTT--TQSPKSSFLASLNPKTWGRLSTQSNSNNIEP 1140

  Fly  1836 ------SGLLSTAQSYPSLSSN--------------------NSENIAPSNP------------- 1861
                  || |:.|.|..::|:|                    :|||:..|||
Human  1141 ARTAGGSG-LARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATE 1204

  Fly  1862 -----------------SNTSAGQQSASTINHT-----LTMSLTSTSSD---SEQVSLEDFLESC 1901
                             |..|....|:..|.|:     |.:.|||.|..   |.::.|:.||...
Human  1205 QLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVF 1269

  Fly  1902 RAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSR--NLLTFMD-------DEAMENR 1957
            .:..|.|              ||.....|.|||..|..:|.:  |.|:.|:       |....|
Human  1270 FSSPLPG--------------EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGN- 1319

  Fly  1958 LVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQ--TSDLEISPL---------------G 2005
              |...|.|...:|....|....:   ...|...||.|  ...::|.||               |
Human  1320 --GTGGRGSQALKFFNTHQLKCQL---QRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYG 1379

  Fly  2006 AELPKPQQS---GGPETIEQPLL---------------GLKLRGPGIGGIPEVE-IDLSNT---- 2047
            ......:.|   |..|.|::.|:               ||.|:...:..|...: ::..|.
Human  1380 RVREDDEDSDDDGSDEEIDESLVRYYIPTMYNVLYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRL 1444

  Fly  2048 -----------DWTIFRAVQEL-LQC--------SQLNKLDKFRKIWEPTYTIVYREVSPEAQES 2092
                       :.|:::||::. :|.        .:.|.|.: ..||..|:||.|:.|. |.:||
Human  1445 QFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDESNPLGR-AGIWTKTHTIWYKPVR-EDEES 1507

  Fly  2093 T--CLESEE-FPQT-PDVSSKSGAST--------------------LSPNSPMHIGFNVADNNLC 2133
            .  |:..:. ..|| |..:|...|..                    |.|..|.:|.|.  |.:|
Human  1508 NKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVSNPLEVYLIPTPPENITFE--DPSL- 1569

  Fly  2134 SVDDVLELLTQINGLNQSEI----DSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNAL 2194
               ||:.||..::.:::...    ::..||    ::....||:.|:|.|..:|:|||||:.:..:
Human  1570 ---DVILLLRVLHAISRYWYYLYDNAMCKE----IIPTSEFINSKLTAKANRQLQDPLVIMTGNI 1627

  Fly  2195 PNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSP---RRDDHE 2256
            |.|...|.::|||.|||:|||:.|..|:|...|::             ||:...:|   :.|..:
Human  1628 PTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAM-------------QRLLDTNPEINQSDSQD 1679

  Fly  2257 FRIG-RLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQ 2320
            .|:. ||..::..|.| |:||..|..||:...:.:::||:::.:|.||||||||||||||:.|:|
Human  1680 SRVAPRLDRKKRTVNR-EELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQ 1743

  Fly  2321 RSDLCMWLCDDDLGEDT--ENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSE---ICENVLKY 2380
            |:||.:|     .||:.  .|...|.||..     |:...: |:|..|..:.::   |.:..:|
Human  1744 RADLGLW-----RGEEVTLSNPKGSQEGTK-----YIQNLQ-GLFALPFGRTAKPAHIAKVKMK- 1796

  Fly  2381 FWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETC 2445
            |.|.|..:||.:.|.||||:||...|.:.
Human  1797 FRFLGKLMAKAIMDFRLVDLPLGLPFYKW------------------------------------ 1825

  Fly  2446 TKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINEL 2510
              :||.:::        |:..:|.:|||...:.:..:::::.:|:.:|.|   .::.|..|...|
Human  1826 --MLRQETS--------LTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQD---KSQTKESLQYAL 1877

  Fly  2511 KLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGI 2575
            :..|.||  .|:|||.|.|| ||     |:...||...|..:.|||.|||.|..|::.:.|.:|:
Human  1878 ETLTMNG--CSVEDLGLDFT-LP-----GFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGV 1934

  Fly  2576 AQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRF 2640
            ::|..:|.|||..||||..|..|.|.|...::||.:...|..:.::....|..||..||...:..
Human  1935 SRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFL 1999

  Fly  2641 VNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGS----YPSVNTCVHYLK 2701
            ..:|.|...::::.||||.||...||.||..:|:|.||:|||......:    .|||.|||:|||
Human  2000 FEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLK 2064

  Fly  2702 LPDYPTEEIMKERLLTATKE--KGFHLN 2727
            ||||.:.|||:|:||.|.:|  :.|||:
Human  2065 LPDYSSIEIMREKLLIAAREGQQSFHLS 2092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	29/134 (22%)
		MIB_HERC2	1333..1389	CDD:310955	10/60 (17%)
		DamX	1576..>1725	CDD:330571	29/168 (17%)
		HECTc	2265..2725	CDD:238033	156/470 (33%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680	30/163 (18%)
		Arm_3	489..>714	CDD:330530	56/280 (20%)
		WWE	808..874	CDD:308464	5/65 (8%)
		HECTc	1690..2090	CDD:238033	156/469 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3704
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850