DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and MAGI1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens

Alignment Length:	1546	Identity:	283/1546 - (18%)
Similarity:	476/1546 - (30%)	Gaps:	532/1546 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 EILQGKPYHW----REWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENG 766
            :::| |..||    .|.::.||..     .:.....|....:|.|.::  |.:|.:.::|.|..|
Human     3 KVIQ-KKNHWTSRVHECTVKRGPQ-----GELGVTVLGGAEHGEFPYV--GAVAAVEAAGLPGGG 59

  Fly   767 NDSSENRGEFLEKLMRARSCVIAGVVSQPILPTA-SALRLVVGNWVLQSQKTNQLQIH------- 823
            .......||.|.::...|   ::|:....:|... |....|....|.|..:.|:...|
Human    60 EGPRLGEGELLLEVQGVR---VSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQ 121

  Fly   824 -NTEGHQV-TVLQDDLPGFIFESNRGTKHTFSAET-------VLGPDFASGWSTAKKKRNKSKTE 879
             .:..|:: ..::|:|          .:|.....|       |.|.|:  .:.|.|:..:..::
Human   122 KGSPDHELQQTIRDNL----------YRHAVPCTTRSPREGEVPGVDY--NFLTVKEFLDLEQS- 173

  Fly   880 GQKFQVRNLSREIYNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKL 944
            |...:|.......|......:|  |.....|.||.:          |...:|:.::|
Human   174 GTLLEVGTYEGNYYGTPKPPSQ--PVSGKVITTDAL----------HSLQSGSKQST-------- 218

  Fly   945 SQLIHEDGVVSAYEMHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESA 1009
                 .....|..:|.::|:|.|      .|..|.:.|....:........       |::....
Human   219 -----PKRTKSYNDMQNAGIVHA------ENEEEDDVPEMNSSFTADSGEQ-------EEHTLQE 265

  Fly  1010 TNKPRTKSTASILIQKLVSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRS 1074
            |..|...|  ||:   ...:.:.::|.|.||
Human   266 TALPPVNS--SII---AAPITDPSQKFPQYL---------------------------------- 291

  Fly  1075 GRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYI 1139
                   ||:....|..     :.:.|                         ...:.|.|.:::|
Human   292 -------PLSAEDNLGP-----LPENW-------------------------EMAYTENGEVYFI 319

  Fly  1140 GSNAKTCDWVNP-----AQYGLVQVTSSEG---------KTLPYG--KLEDILSRDSISLNCHTK 1188
            ..|.||..|::|     .|..|.:....||         ..||.|  |:||.:
Human   320 DHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPV------------ 372

  Fly  1189 DNKKAWFAIDLGVYII-----PTAY-----------TLRHARGYGRSALRNWLLQGSKDGSTWTT 1237
                      .|:|.:     .|.|           .|...:...:...:....|..:....||.
Human   373 ----------YGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTE 427

  Fly  1238 LSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQ------QNGRNASGQTHYLSLS------ 1290
                 |..:||.|......|.|...     .|.:.:|      :|.....|:..:..|.
Human   428 -----DHSALVPPVIPNHPPSNPEP-----AREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGF 482

  Fly  1291 GFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQL--------KHMTTGARVIRGVDWRWEEQ 1347
            ||.:.|   |...|              |..||::.:        ..|.||..::       ...
Human   483 GFTVVG---GDEPD--------------EFLQIKSLVLDGPAALDGKMETGDVIV-------SVN 523

  Fly  1348 DGCAEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCE-YLSAFDGNQSMGSASTAAK 1411
            |.|..|....::      ||    :..|..:||  ..||:|  |. |...||.:....|..|:..
Human   524 DTCVLGHTHAQV------VK----IFQSIPIGA--SVDLEL--CRGYPLPFDPDDPNTSLVTSVA 574

  Fly  1412 PSEK------GGNTLTSRKSSST------------PSLPEATEKNQNPEGASNQTVS-ADNLAWK 1457
            ..:|      |..|..|..|.|:            ||.|.....|.: .|..|.||| |.::|.:
Human   575 ILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSS-HGYPNDTVSLASSIATQ 638

  Fly  1458 Q---TVE----------TIAENVFASAK--TQIISNQLAMNTSSSR---EARAKHKESGT-NQMH 1503
            .   ||.          |||::.....:  .||:.:..........   |...|:.::.| ||:.
Human   639 PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVV 703

  Fly  1504 KDNISGP-------------------SPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLS 1549
            ...:..|                   ||.|:.||.              ..|..|...::|.:.|
Human   704 DMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLER--------------KDSQNSSQHSVSSHRS 754

  Fly  1550 LTELSKENICRVLTPSYKPAESVTASQSSS----HPD-----VQSSSPRENDIKNISNIEENNKM 1605
            |...|..:..:|| |.:.|||:....|:.|    .||     .||.|..||.:.:..
Human   755 LHTASPSHSTQVL-PEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQ-------- 810

  Fly  1606 NANNSVNKISKDLLA---------NLRTSNIAGCP-------PVTQLSTEALEMIDKMRDGVDMI 1654
                     .:|:..         .:...|..|.|       |:....|:.     ::|.|.::|
Human   811 ---------EQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDG-----RLRSGDELI 861

  Fly  1655 RNMSNSILSTDTFPVPCTN-VPVGGKKTPKAQALINPD------NANQKQIIV-----TSEEFPT 1707
                            |.: .||.||.......|:...      |...::.:|     |..|.|:
Human   862 ----------------CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPS 910

  Fly  1708 KSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATH 1772
            .:|...|     :.||   .|:.:.|..|..::|            :|.|.|:.. .|||.:.:.
Human   911 PASSHHS-----SNQP---ASLTEEKRTPQGSQN------------SLNTVSSGS-GSTSGIGSG 954

  Fly  1773 TG--------LLETFAAIARRRTSQGTN-IQDNQIMNAEA----------------NVNEHGDQN 1812
            .|        :::.:....||..::|.. :..:.:...||                .:.|....:
Human   955 GGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPAD 1019

  Fly  1813 ASGSF-LGHSVTSLVKLALSSNFHSGLLS---------TAQSYP-SLSSN-----NSENIAPSNP 1861
            ..|.. :|..:.::...::::..||.:::         |.:..| ..|||     |:|.||....
Human  1020 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITT 1084

  Fly  1862 SNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLE-DF--LESCRAP-----ALLGDLDDEDDMD- 1917
            ::|.:.|.:..|.|.|.....:.....:.|.:.| ||  :|..|..     :|.|  ..|.:||
Human  1085 THTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRG--GREYNMDL 1147

  Fly  1918 ------EDNDEEENEDEYEEVGNTLLQV--MVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLK 1974
                  ||...|....  ..:|:.:|::  ..::|:        ..:|.:.:.|.........||
Human  1148 YVLRLAEDGPAERCGK--MRIGDEILEINGETTKNM--------KHSRAIELIKNGGRRVRLFLK 1202

  Fly  1975 RQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLL 2025
            |. ...:|.:||...|...      ...|.|.    |:...||:..:.|.|
Human  1203 RG-DGSVPEYDPSSDRHGP------ATGPQGV----PEVRAGPDRRQHPSL 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	24/152 (16%)
		MIB_HERC2	1333..1389	CDD:310955	11/55 (20%)
		DamX	1576..>1725	CDD:330571	33/185 (18%)
		HECTc	2265..2725	CDD:238033
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492	19/94 (20%)
		GuKc	122..293	CDD:214504	39/267 (15%)
		WW	303..332	CDD:238122	8/53 (15%)
		WW	361..390	CDD:278809	10/50 (20%)
		PDZ	469..555	CDD:214570	24/123 (20%)
		PDZ	640..723	CDD:214570	13/82 (16%)
		MAGI_u5	722..805	CDD:293271	25/97 (26%)
		PDZ_signaling	819..894	CDD:238492	15/95 (16%)
		PDZ_signaling	968..1062	CDD:238492	11/93 (12%)
		PDZ	1123..1205	CDD:214570	18/94 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900