Protein Alignment Ufd4 and UBE3B

DIOPT Version :9

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: NP_569733.2
• Gene: UBE3B / 89910
• HGNCID: 13478
• Length: 1068
• Species: Homo sapiens
• Alignment Length: 1106
• Identity: 204/1106 - (18%)
• Similarity: 374/1106 - (33%)
• Gaps: 328/1106 - (29%)

  Fly  1762 EVPSTSEVAT-HTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSL 1825
            |:...|.:.| :..:|.||...:..:..:|........||       |...|..|....|...|:
Human   151 EILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPAMN-------HICANIMGHLNQHGFYSV 208

  Fly  1826 VKLALSSN-------FHSGLLSTAQSY---PSLSSNNSENI----------APSNPSNTSAGQQS 1870
            :::.|:..       ...|.|:.|.|.   |.:::..|:|:          .|:..::.|.....
Human   209 LQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPE 273

  Fly  1871 ASTI--NHTLTMSLTSTSSDSEQV-SLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEV 1932
            ..|:  :|.:.........|.::. .:.:.||.|....|:|:|.....:.....|||.:.....:
Human   274 RLTVLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLL 338

  Fly  1933 GNTLL----QVMVSRNLLTFMD----------DEAMENRLVGVTKRKSWDDEFVLKRQF------ 1977
            ..||.    .|...::.||...          |..:...:..:||:..:.....|.|.|
Human   339 TQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILS 403

  Fly  1978 SALIPAFDPRPGRTNVNQTSDLEISPLGAELPKP-QQSGGPETIEQPLLGLKLRGPGIGGIPEVE 2041
            ..|:.:.:|    .:....|...:.|:.:.|.:. |:|.....|.:|:.|.::....:..:..:.
Human   404 KKLLESQEP----AHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNIC 464

  Fly  2042 I--DLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTP 2104
            :  ..|.|..|..| :|.|...:.|:  |...|:|
Human   465 VLYQTSLTTLTQIR-LQILTGLTYLD--DLLPKLW------------------------------ 496

  Fly  2105 DVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEI----DSDVKEHGVSVL 2165
                 :....|.|:..:.:.....:|:......:|.:|......::..|    |.:|.|..:|..
Human   497 -----AFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFK 556

  Fly  2166 SEDL---------FISKKITNKLQQQIQDPLVLASNALPNW--------CEN------------- 2200
            .|:|         |:.|.|.:.:.:..:...:....::..|        |..
Human   557 LEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFTPEDHWLRKDL 621

  Fly  2201 ------------------LNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPI 2247
                              :.|..|.:.|.:.|.|.|...                ||.|::::.:
Human   622 KPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM----------------VTKEKEKLGL 670

  Fly  2248 M-----SPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEG---TG 2304
            :     ||    |...| .::..|:.....|.|...:...|      |.|:.|:|:::.|   .|
Human   671 VETSSASP----HVTHI-TIRRSRMLEDGYEQLRQLSQHAM------KGVIRVKFVNDLGVDEAG 724

  Fly  2305 LGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQ 2369
            :.....|...:...|:|      :.|..|     |..::..|:.:            ::|:|
Human   725 IDQDGVFKEFLEEIIKR------VFDPAL-----NLFKTTSGDER------------LYPSP--- 763

  Fly  2370 NSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLC--HNKVLSRNLQKVISDRRNGDL 2432
            .|.|.||.|:.|.|.|..:.|.:.:..:||:|.::.||..|.  |:.|...::.:
Human   764 TSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDE---------- 818

  Fly  2433 SVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDT 2497
             :.|.||:..:..|.:.|.|.:
Human   819 -LPSLDSEFYKNLTSIKRYDGD------------------------------------------- 839

  Fly  2498 ISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQA-ELLPNGSSVNVTIDNLEA 2561
                                    :.||.||.:|  ...:.|.... ||:|.|.::.||.:|..:
Human   840 ------------------------ITDLGLTLSY--DEDVMGQLVCHELIPGGKTIPVTNENKIS 878

  Fly  2562 YCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEP 2626
            |..|:.:|.:...|..|..|...||..:...:.:..|:..|.:.:|.|:. .....||:..:|..
Human   879 YIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDN-AEIDLEDLKKHTVY 942

  Fly  2627 KLGYNKDSPGFQRFV----NVLLS-MSGDERKAFLQFTTGCSSLPPGGLANLHPRLTV------- 2679
            ..|::    |..|.:    ::|.| .:.|||..||:|.|.||..|..|.|.|.|..::
Human   943 YGGFH----GSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD 1003

  Fly  2680 -----------------VRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTA-TKEKGFHL 2726
                             :||.:.| |..|:.:||.:.||||:|..:.:::|:|..| :...||.|
Human  1004 DQDTGDTLGSVLRGFFTIRKREPG-GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067

  Fly  2727 N 2727
            :
Human  1068 S 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	105/495 (21%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	106/502 (21%)
		HECTc	707..1065	CDD:214523	100/469 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900