Protein Alignment Ufd4 and RSP5

DIOPT Version :9

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: NP_011051.3
• Gene: RSP5 / 856862
• SGDID: S000000927
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 1158
• Identity: 218/1158 - (18%)
• Similarity: 361/1158 - (31%)
• Gaps: 454/1158 - (39%)

  Fly  1658 SNSILSTDTF--PVPCTNVPVGG---KKTPKAQALINP--------DNANQKQIIVTSEEFPTKS 1709
            :.|:...|.|  |.|...:.:.|   |.|..|:..:||        |:.|:..|: |.:.|..|.
Yeast    12 AESLYKRDVFRSPDPFAVLTIDGYQTKSTSAAKKTLNPYWNETFKFDDINENSIL-TIQVFDQKK 75

  Fly  1710 SKKPSVTLKPAQQPNAVLSIVDI--------------------KEQPI------SNENVSVPSQM 1748
            .||         :....|.:|::                    :|:.|      ||:.::|..::
Yeast    76 FKK---------KDQGFLGVVNVRVGDVLGHLDEDTATSSGRPREETITRDLKKSNDGMAVSGRL 131

  Fly  1749 SISVPNLTTTSA-SEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQN 1812
            .:.:..|.::|. |:.||     .||             .|..||.......|
Yeast   132 IVVLSKLPSSSPHSQAPS-----GHT-------------ASSSTNTSSTTRTN------------ 166

  Fly  1813 ASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHT 1877
                  |||.:       |:..||      .|:|  |...::.:..:..|.|:|...:|:|.:.
Yeast   167 ------GHSTS-------STRNHS------TSHP--SRGTAQAVESTLQSGTTAATNTATTSHR- 209

  Fly  1878 LTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEY-----------EE 1931
               |..||||.:.|.|                              ..||:|           :.
Yeast   210 ---STNSTSSATRQYS------------------------------SFEDQYGRLPPGWERRTDN 241

  Fly  1932 VGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGR--TNVN 1994
            .|.|.           ::|..         |:..:|      ||      |..|.....  ..:|
Yeast   242 FGRTY-----------YVDHN---------TRTTTW------KR------PTLDQTEAERGNQLN 274

  Fly  1995 QTSDLE-ISPLGAELPKPQQSGGPETIE-------QPLLGLKLRG--------PGIGGIPE---- 2039
            ..::|| ....|..||.........|::       .|:.|.....        .|:|.:|.
Yeast   275 ANTELERRQHRGRTLPGGSSDNSSVTVQVGGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQ 339

  Fly  2040 ----------VEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTC 2094
                      |:.:...|.|...|..|             :.:.:.||.|.:.::
Yeast   340 RFTPEGRAYFVDHNTRTTTWVDPRRQQ-------------YIRTYGPTNTTIQQQ---------- 381

  Fly  2095 LESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKE 2159
                               .:|...|:..|:.:...|...|..|                    :
Yeast   382 -------------------PVSQLGPLPSGWEMRLTNTARVYFV--------------------D 407

  Fly  2160 HGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCP-FLFPFETRQLYFNCTSF 2223
            |.....:.|                ||      .||:   :|:|:.| :...|..:.:||.
Yeast   408 HNTKTTTWD----------------DP------RLPS---SLDQNVPQYKRDFRRKVIYFR---- 443

  Fly  2224 GASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCN 2288
             :..::..|..|..:.|.|:.|      .:|        .::.:.....|||
Yeast   444 -SQPALRILPGQCHIKVRRKNI------FED--------AYQEIMRQTPEDL------------- 480

  Fly  2289 RKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVG 2352
             |..|.::|..|||... |.:.||:.|::.|:.....|::             ..||..|
Yeast   481 -KKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLF-------------EYSAYDN----- 526

  Fly  2353 YYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLS 2417
                      :...:..||.|....|.||.|.|..|...:...|.:|.....:..:::...||:.
Yeast   527 ----------YTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVL 581

  Fly  2418 RNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEM 2482
            ::::.|              |:::..:...:|      .|:..|:|.|
Yeast   582 QDMEGV--------------DAEVYNSLNWML------ENSIDGVLDL----------------- 609

  Fly  2483 QNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLP 2547
                          |.||:  .|...|:                              ...:|.|
Yeast   610 --------------TFSAD--DERFGEV------------------------------VTVDLKP 628

  Fly  2548 NGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQF 2612
            :|.::.||..|.:.|.||...:.:.|.:.:|.|||.|||||:.|...:..|...|..::|.|  .
Yeast   629 DGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGG--I 691

  Fly  2613 PHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLH--- 2674
            .....||...:|:.: ||.:.....|.|...:.....::|...||||||.|.:|..|..:|.
Yeast   692 AEIDIEDWKKHTDYR-GYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSD 755

  Fly  2675 -PRLTVVRKVDAG-VGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEK-GF 2724
             ||...:.|  || |...|..:||.:.:.||.|...:.||::|..|.:|. ||
Yeast   756 GPRRFTIEK--AGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGF 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	19/79 (24%)
		HECTc	2265..2725	CDD:238033	104/467 (22%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	218/1158 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900