DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and HUL4

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	1071	Identity:	205/1071 - (19%)
Similarity:	350/1071 - (32%)	Gaps:	338/1071 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1804 NVNEHG-DQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSA- 1866
            |..:.| |.:.|...|.|||.........|...:...|.|.|....|.:||:    ||..|:||
Yeast     9 NAKKDGRDGSVSKELLSHSVAHTKNRLPKSGRRTSERSLAASVKDGSCSNSK----SNKRNSSAS 69

  Fly  1867 --GQQSASTINHTLTMSLTSTSSDSE---QVSLEDF-LESCRAPALLGDLDDEDDMDEDNDEEEN 1925
              |::..|.:     :||........   ..|:..| ..:|:...::          ::.:...|
Yeast    70 VSGEEDKSCL-----ISLNCLCCGVPLRFPASITKFRCSACQVTVIV----------KEPEINSN 119

  Fly  1926 EDEYEEVGNTL--LQVMVSR----------------------------NLLTFMDDEAMENR--L 1958
            .:....:..||  ||::|.|                            .||....|.::.||  |
Yeast   120 LESSTHISCTLEGLQMVVRRCHDDLQRLKKTGILDKERKGLIFQPVITYLLDRFHDVSILNRSFL 184

  Fly  1959 V--GVTKRKSWDDEFVLKRQFSAL--IPAFDPRPG----------RTNVNQTSDLE--------- 2000
            |  |....|..:.| ||:|.:|.|  :|...|...          |..:|:..:|:
Yeast   185 VHDGGKNIKMLNYE-VLQRFYSILSNLPTRKPYYSMLCCCNDLLKRITINKGENLQILQYRWLLI 248

  Fly  2001 ---ISPLGAELPKPQQSGGP-ETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQC 2061
               |..:...|.:.::|... ||.:...:..:|....||.:..:....|          |:|:|.
Yeast   249 ILNIPTIRTCLIRDRKSKNVFETQQIRAVSYELAKRCIGYLSNLSTKTS----------QQLIQS 303

  Fly  2062 SQLNKLDKFRKIWEPTYTI----VY-------------------REVSPEAQESTCLE-----SE 2098
            .:....|.|      :|.:    :|                   ..|.||.:..:.|.     ..
Yeast   304 LRRTPTDNF------SYQVEILNLYINFQFSRLLSNELSNRTAKNNVKPEDEMRSRLRRHHTTGH 362

  Fly  2099 EFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCS-----------VDDVLELL-------TQI 2145
            ||..|..:|::|       |.....||....||...           :....:|.       |:.
Yeast   363 EFLSTRPISAQS-------NDKQGSGFTHPVNNKMKFKFFQYEEDWHIHSAAKLTFIYYVANTRR 420

  Fly  2146 NGLNQSEIDS---------DVK---EHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWC 2198
            ||.....|.|         |.|   :|...|..:         .|:.|.|::           |.
Yeast   421 NGRGALSIQSFYNITLDFIDYKQDFDHWRGVAQK---------TKMNQLIEE-----------WG 465

  Fly  2199 ENLNQSC------PFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEF 2257
            .:..:.|      ||:.            |.|...||:..:.:|.:..|.::..::|..:
Yeast   466 NSTTKKCFSFCKYPFIL------------SLGIKISIMEYEIRRIMEHEAEQAFLISLDK----- 513

  Fly  2258 RIGRLKHERVKVPRNEDLLMW-AMQVMKTHCN--RKSVLEVEFLDEEGTGLGP-TLEFYALVAAE 2318
              |:......|:....|::.. :::.:|.|..  .|| |.:||::|.|...|. ..|::.|:
Yeast   514 --GKSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKS-LRIEFVNEPGIDAGGLRKEWFFLL--- 572

  Fly  2319 IQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLP-------QNSEICEN 2376
                                  |:|.......:..|:.......|....|       :||:
Yeast   573 ----------------------TKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQ---- 611

  Fly  2377 VLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDI 2441
             |:.::.|||.:...:.:..::|:....:..:.||                        ||.
Yeast   612 -LELYYLFGVVMGLAIFNSTILDLQFPKALYKKLC------------------------SEP--- 648

  Fly  2442 VETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHEL 2506
                                 ||.|:..|:.|...:.|.:|.|.    ....|:|..|      |
Yeast   649 ---------------------LSFEDYSELFPETSRNLIKMLNY----TEDNFEDVFS------L 682

  Fly  2507 INELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFIL 2571
            ..|...:..|.:   |.|         |.|...|...||..||.:|.:|..|...:....:.|.|
Yeast   683 TFETTYRNNNWI---LND---------SKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYL 735

  Fly  2572 QDGIAQQMKAFSDGFNEVF-PLKKLAAFTPSEARMMICGEQ----FPHWSREDIISYTEPKLGYN 2631
            :..|..|...|..||..|| ....:..|...|...::||::    |...|...:..|..   |::
Yeast   736 EKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVG---GFS 797

  Fly  2632 KDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTC 2696
            .||.....|..::.|.....:|..|||.|....:|..|::.:..:::::...|:  ...|..:||
Yeast   798 DDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDS--DDLPLAHTC 860

  Fly  2697 VHYLKLPDYPTEEIMKERLLTATKEK---GF 2724
            .:.:.|.:|.:::.::.:||.|..|.   ||
Yeast   861 FNEICLWNYSSKKKLELKLLWAINESEGYGF 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	96/479 (20%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	205/1071 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900