DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and TOM1

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_010745.3 Gene:TOM1 / 852068 SGDID:S000002865 Length:3268 Species:Saccharomyces cerevisiae


Alignment Length:2556 Identity:475/2556 - (18%)
Similarity:847/2556 - (33%) Gaps:769/2556 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   458 LHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAI----LQSPGEWMSP 518
            ||:...|  |.|.||.|         .|....|.|.|...|.|...::.|.    |.||.:| ..
Yeast  1194 LHWDLIF--PPIKKISL---------FEQVGIPGDVAANYLTDTGDDLPADNSIGLFSPEQW-EK 1246

  Fly   519 DHSLLNKDGKKYTLMEPRGDPEMAPIY-------LKVLLPIFCRTFLGSMLGSVRRASLALIKKI 576
            ...|:.:|...|   .|:  |..|..|       |..|...|....|.|.:.:|    |....|:
Yeast  1247 YKKLIGEDKSIY---YPQ--PMQAQYYKGCSSKELDELRDTFFNDGLPSRIFTV----LPFYPKL 1302

  Fly   577 VQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVLDN--EDDGDGHLIVLNIIEEIMCK 639
            |.....|:||..  |.:.|.....:|:            :||.  |.|.|....:.::|......
Yeast  1303 VNAFAKTLLQIF--TKYDEPTEVFAGR------------ILDRILETDLDDPATLSSLIHLFGIF 1353

  Fly   640 TQEEFLDHFARLGVFAKVQALMDTDAEELYVQL-PGTVEEPAAAQRSSTSVVVAPRPTSDDPMED 703
            ..|::        ::.|...||....|.|...| |..|..|..::......::..:.......|.
Yeast  1354 LNEKY--------IYQKASHLMQRFIEYLEKSLKPEHVNTPWFSKALYVYEIILAKSELPHLEEL 1410

  Fly   704 AKEILQGKPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYS--------- 759
            :|::|...|. .....:.|..|.:......:.:.:|:.|| ::..:...::...||         
Yeast  1411 SKDVLLRYPL-LSMAKVFRIPDPMKQKLFDILIRVSDISN-FYSALATSRILIFYSRDELYANNI 1473

  Fly   760 --SGSPEN-----GNDSSENRGEFLEK--LMRARSCV-----IAGVVSQPILPTASALRLVVGNW 810
              ||....     |:....::..|||.  |:..|.|.     :..::...|..:.:|..|..|:.
Yeast  1474 ARSGILSRLLKVIGSFQKLDKINFLESSFLLLTRRCFETTENVDALIRAEINRSFTARPLGGGDD 1538

  Fly   811 VLQSQKTNQLQIHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNK 875
            .::...|    |...:.|.|..........:.|:.|  .|.|..:..| .|::......:|.:|.
Yeast  1539 AVRELTT----ILEEKAHVVMRSPSQFIDVLCETAR--FHEFDDQGAL-VDYSLKRFLGEKDKNT 1596

  Fly   876 SKTEGQKFQVRNLSREIYNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDA 940
            ..:..:|       .:||.:            ..|:..::.|:..:.|:..::...| .:.|.: 
Yeast  1597 QASSTEK-------SDIYER------------TGIMHLLLSQLMAASEKDWLSEPAN-SSDLPE- 1640

  Fly   941 LMKLSQLIHEDGVVSAYEMHSSGLVQALVAVLSVNHWE--TNSPR---CKRNKMQKQRVSVFKKC 1000
             .|.:||......|.||.:....|:..||:..:...:|  |.|.|   .:|.:.:...::.|...
Yeast  1641 -NKKAQLDPSRNPVCAYMIFLLKLLVELVSSYNQCKFEFLTFSRRNTYAERPRPRTTAINFFLYR 1704

  Fly  1001 ILEDNVESATNKPRTKS-------TASILIQKLVSVLES-TEKLPVYLYDSPCT---GYSLQILQ 1054
            :|:..|.:..:|...|.       ..|::|..|.:|.:. |.|..|.|.|....   .::::.:.
Yeast  1705 LLDKPVGTDHDKHEAKRREVIGMLARSVIIGFLATVQDDRTTKTDVKLADPHMNFIRKFAIEAII 1769

  Fly  1055 KRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYD---LDRSTYFYLKKIR 1116
            |.:|    .|...|.|.:  ...||::....|.....|:.....:|..|   ::...|...|.:.
Yeast  1770 KAIR----NATSSSKLLE--SNHLKLDMWFRIITSMVYVQAPYLRQLLDSNKVEADQYQLCKLVI 1828

  Fly  1117 EHRTATVFTH-------SFDFDEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSEGKTLPYGKLED 1174
            :....:|.|.       ::.|.::  :|            |.|...|..::|:......:.|:||
Yeast  1829 DLGLPSVITEAMASIDLNYPFSKK--IF------------NVAVEALNTISSTRNNFSEHFKIED 1879

  Fly  1175 ILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLS 1239
               .|.:.......|.::           ||..:.        .|||..:.::..::...     
Yeast  1880 ---HDEVEDEVDESDKEE-----------IPDMFK--------NSALGMYDVEDIEEDDD----- 1917

  Fly  1240 THVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADD 1304
               ||.||:            ..||::.:..                 |.:|||:.  .....||
Yeast  1918 ---DDTSLI------------GDDDAMAFVD-----------------SDNGFEVV--FSDEDDD 1948

  Fly  1305 IGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITG-EIHNGWIDVKW 1368
            :|:...: :|::..|..::.::::..|..     |.|..:|..|  |:|.|.. :..:|..:...
Yeast  1949 MGEEDAD-DARSDSEENELSSEMQSSTAD-----GTDVDYEVDD--ADGLIINIDQPSGDDEEMA 2005

  Fly  1369 DHGVRNSYRMGAEGK------------------YDLKLADCEYLSAFDGNQSMGSASTAAKPSEK 1415
            |:....|:...:|.:                  ||:.|:|.: :...|.:..:.|.|.:.:.||.
Yeast  2006 DYDANISHSSHSENEDDASMDVIEVYDDELSSGYDVDLSDYD-VDESDWDSGLSSLSISDEDSES 2069

  Fly  1416 GG----NTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQII 1476
            ..    |:.....|.....:.|..|...:.:|.|.:    |:....:.:|.|..|          
Yeast  2070 SEDEPINSTRMGDSRRRWLIAEGVELTDDSQGESEE----DDRGVFRGIEHIFSN---------- 2120

  Fly  1477 SNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAIN----NSMPAINSSN 1537
            .|:...........|..|:.......| ..:|.||           ||.:|    |....||...
Yeast  2121 ENEPLFRVHDEMRHRNHHRSINRTHFH-SAMSAPS-----------LSLLNRGRRNQSNLINPLG 2173

  Fly  1538 VSDLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPD---------VQSSSPRENDI 1593
            .:.|..:..::|                    :.||.:.|.|.|.         :.|.|..:..:
Yeast  2174 PTGLEQVENDIS--------------------DQVTVAGSGSRPRSHHLHFSEVLVSGSFFDEPV 2218

  Fly  1594 -------------KNISNIEENNKMNAN-------NSVNKIS----KDL-----LANLRTSNIAG 1629
                         |:|.::..::|..||       |.:.|:|    |||     ...|:..|:  
Yeast  2219 LDGIILKSTVSRWKDIFDMFYDSKTYANCIIPTVINRLYKVSLALQKDLENKREQEKLKNKNL-- 2281

  Fly  1630 CPPVTQLSTEALEMIDKMRDGVDMIRN--MSNSILSTDTFPVPCT----NVPVGGKKTPKAQALI 1688
                  |..||........|.:.:.::  ..:::...|..||..|    .|.:||..       |
Yeast  2282 ------LFNEAKVESHNSSDAISVEQDDIQESNVTHDDHEPVYVTIQGSEVDIGGTD-------I 2333

  Fly  1689 NPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENV---SVPSQMSI 1750
            :|:..|.....:.::.|.....::         :..|.|:         |:.||   .:.|....
Yeast  2334 DPEFMNALPDDIRADVFAQHVRER---------RAEARLN---------SDHNVHSREIDSDFLE 2380

  Fly  1751 SVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQ----DNQIMNAEANVN---EH 1808
            ::|.               ....|:|:|.|...|.....|::..    |:.:.|.:..|.   :|
Yeast  2381 AIPE---------------DIREGILDTEAEEQRMFGRIGSSADVIRADDDVSNNDEEVENGLDH 2430

  Fly  1809 GDQNASGS---------------FLGHS-VTSLVKLALSSN-------FHS---GLLSTAQSYPS 1847
            |:.|...:               .:..: :.||:|....|.       :|.   .|.|:.|:...
Yeast  2431 GNSNDRNNADPEKKKPARIYFAPLIDRAGIASLMKSVFISKPYIQREIYHELFYRLCSSKQNRND 2495

  Fly  1848 LSSN----NSENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLG 1908
            |.:.    .||.|...:.........|:..:.|..|.::....||...:::.:     :...:|.
Yeast  2496 LMNTFLFILSEGIIDQHSLEKVYNIISSRAMGHAKTTTVRQLPSDCTPLTVAN-----QTIEILQ 2555

  Fly  1909 DLDDEDD-------MDEDN---DEEENEDEYEEVGNTLLQ-------VMVSRNLLTFMDDEAM-- 1954
            .|.|.|.       .:.||   ::..|:...|.:.:..|:       .::.|.|:|   ||::  
Yeast  2556 SLIDADSRLKYFLIAEHDNLIVNKANNKSRKEALPDKKLRWPLWHLFSLLDRKLIT---DESVLM 2617

  Fly  1955 --------------------ENRLVGVTKR---KSWDDEFVLKRQFSALIPAFDPRPGRTNVNQT 1996
                                .|....::|:   .|:|::.::|.....::.:...|..:..:|..
Yeast  2618 DLLTRILQVCTKTLAVLSTSSNGKENLSKKFHLPSFDEDDLMKILSIIMLDSCTTRVFQQTLNII 2682

  Fly  1997 SDLEISPLGAELPKPQQSGGPETIEQPLLGL------KLRGPGIGGIPEVEIDLSNTDWTIFRAV 2055
            .:|.           :..|......:.|:.|      ||:....|        ||....||...:
Yeast  2683 YNLS-----------KLQGCMSIFTKHLVSLAISIMSKLKSALDG--------LSREVGTITTGM 2728

  Fly  2056 Q---ELLQCSQLNKLD--KFRKIWEPTYTIVYREVSPEAQE---------------------STC 2094
            :   ||||...|...|  |..||. .|...:|.....|.:.                     |.|
Yeast  2729 EINSELLQKFTLPSSDQAKLLKIL-TTVDFLYTHKRKEEERNVKDLQSLYDKMNGGPVWSSLSEC 2792

  Fly  2095 LESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKE 2159
            |...|..|..:.|    |:.|.|                 :.:.|.::.:.:.|:|:. ::.||.
Yeast  2793 LSQFEKSQAINTS----ATILLP-----------------LIESLMVVCRRSDLSQNR-NTAVKY 2835

  Fly  2160 HGVSVLS------EDLFI-----SKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFET 2213
            ....:|.      |:||.     .||:.|   |.|:....|.|.......:|     |.:..|:.
Yeast  2836 EDAKLLDFSKTRVENLFFPFTDAHKKLLN---QMIRSNPKLMSGPFALLVKN-----PKVLDFDN 2892

  Fly  2214 RQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMW 2278
            ::.:||..          |:|...   ||.::||                     ..|.|.:.:.
Yeast  2893 KRYFFNAK----------LKSDNQ---ERPKLPI---------------------TVRREQVFLD 2923

  Fly  2279 AMQVMKTHCN---RKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTEN 2339
            :.:.:....|   :.|.||:.|..|.|... |.|.|:|.:::.::...|..::|           
Yeast  2924 SYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFL----------- 2977

  Fly  2340 STQSAEGNSKPV-----GYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVD 2399
                      ||     .::.||.. ||.|           ..|.:|.|.|:.:.|.::|...:|
Yeast  2978 ----------PVPSDKTTFHPNRTS-GINP-----------EHLSFFKFIGMIIGKAIRDQCFLD 3020

  Fly  2400 IPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILS 2464
                       ||   .||.:.|                                  |..|..:|
Yeast  3021 -----------CH---FSREVYK----------------------------------NILGRPVS 3037

  Fly  2465 LENLKEIDPTRYQFL-----QEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLED 2524
            |::::.:||..|:.|     .::.:::....|:|.||    ..:|::||                
Yeast  3038 LKDMESLDPDYYKSLVWILENDITDIIEETFSVETDD----YGEHKVIN---------------- 3082

  Fly  2525 LALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEV 2589
                                |:..|..:.||..|.:.|.:.::.:.||..:.:||..|..||..:
Yeast  3083 --------------------LIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYAL 3127

  Fly  2590 FPLKKLAAFTPSEARMMICGEQFPHWSRED------IISYTE--PKLGYNKDSPGFQRFVNVLLS 2646
            .....:..|...|..::|.|  .|....:|      .::||.  .::.|         |...:.|
Yeast  3128 ISKDLITIFDEQELELLISG--LPDIDVDDWKNNTTYVNYTATCKEVSY---------FWRAVRS 3181

  Fly  2647 MSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVR-KVDAGVGS---YPSVNTCVHYLKLPDYPT 2707
            ...:||...|||.||.|.:|..|...|.....|.: .:....||   .||.:||.:.|.||.|.:
Yeast  3182 FDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYES 3246

  Fly  2708 EEIMKERLLTATKE--KGFHL 2726
            .|.::..||.|..|  :||.|
Yeast  3247 YETLRGSLLLAINEGHEGFGL 3267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125 15/54 (28%)
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786 8/25 (32%)
F5_F8_type_C 1173..1298 CDD:329041 19/124 (15%)
MIB_HERC2 1333..1389 CDD:310955 13/74 (18%)
DamX 1576..>1725 CDD:330571 33/192 (17%)
HECTc 2265..2725 CDD:238033 101/487 (21%)
TOM1NP_010745.3 DUF908 92..387 CDD:399185
DUF913 448..>683 CDD:399192
MSCRAMM_ClfB <1879..2061 CDD:411414 41/251 (16%)
DUF4414 2328..2357 CDD:405126 6/35 (17%)
HUL4 2385..3268 CDD:227354 212/1107 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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