DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_036017204.1	Gene:	Nedd4l / 83814	MGIID:	1933754	Length:	1261	Species:	Mus musculus

Alignment Length:	1195	Identity:	235/1195 - (19%)
Similarity:	396/1195 - (33%)	Gaps:	399/1195 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1679 KKTPKAQALI----NPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNA-------VLSIVDI 1732
            ::||::...:    ...||.|:...:.....|.::.:....|.|....|.|       .|..||:
Mouse   313 ERTPQSPGCMFKIRQDQNAGQQHFRILVTRGPEEAPQNQEETHKSPGHPGAGAPTRDDFLGQVDV 377

  Fly  1733 KEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSE-----VATHTGLLETFAAIARRRTSQGTN 1792
               |:|:.....|:.              |.|.|.:     ..:|...::.|..:......:...
Mouse   378 ---PLSHLPTEDPTM--------------ERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGG 425

  Fly  1793 IQDNQIMNAEANVN-EHG----DQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNN 1852
             ||.:  |:|...: |||    |.|.|                                  :|.:
Mouse   426 -QDEE--NSEQRDDMEHGWEVVDSNDS----------------------------------ASQH 453

  Fly  1853 SENIAPSNPSNTSAGQQSASTINHTLTM------------SLTSTSSDSE----QVSLEDFLESC 1901
            .|.:.|  |......::....:..|..:            ||...||:|:    |::.|......
Mouse   454 QEELPP--PPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRF 516

  Fly  1902 RAPALLGDLDDEDDMDEDNDE-----EENEDEYEEVGNTLLQVM-------VSRNLLTFMDDEAM 1954
            |:...:.: |.|.:..|...|     |...:|....|::|...:       |||.....:.:|.
Mouse   517 RSRRHISE-DLEPEASEGGGEGPEPWETISEEMNMAGDSLSLALPPPPASPVSRTSPQELSEEV- 579

  Fly  1955 ENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQ------ 2013
             :|.:.:|...:.:       |||:||    .|...:.:...|..:.....|.||.|..
Mouse   580 -SRRLQITPDSNGE-------QFSSLI----QREPSSRLRSCSVTDTVAEQAHLPPPSTPTRRAR 632

  Fly  2014 ----SGGPETIEQPLLGLKLRGPGI-----------GGIPEVEIDLSNTDWT--IFRAVQELLQC 2061
                :||.|:  .|.:......||:           |....|..:...|.||  |.:..::....
Mouse   633 SSTVTGGEES--TPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASG 695

  Fly  2062 SQLN--------KLDKFRKIWEPTYTIVY----REVSP--EAQESTCLESEEFPQ-----TPDVS 2107
            |..|        ::.:.|.:..||.|:..    .:.||  .|.:.| |.:.:.||     :|...
Mouse   696 SATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDT-LSNPQSPQPSPYNSPKPQ 759

  Fly  2108 SKSGASTLSPNSPMHIGFN----VADNNLCSV---DDVLELLTQIN---GLN-----------QS 2151
            .|...|.|.|...|.|..|    ..|:|..:.   |..|:....:.   .||           :.
Mouse   760 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEE 824

  Fly  2152 EIDSDVK----EHGVSVL--------SEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQS 2204
            .|..|.:    :|...||        |..|:.| |||.....::|:|.:            ...:
Mouse   825 RIHLDGRTFYIDHSSQVLCGENDTRESVPLYDS-KITQWEDPRLQNPAI------------TGPA 876

  Fly  2205 CPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDD---HEFRIGRLKHER 2266
            .|:...|:.:..||.                     ::.:.|...|.|.:   |...|....:.|
Mouse   877 VPYSREFKQKYDYFR---------------------KKLKKPADIPNRFEMKLHRNNIFEESYRR 920

  Fly  2267 VKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTL-EFYALVAAEIQRSDLCMWLCD 2330
            :...:..|:|             |:.|.:||..|:|...|... |::.|::.|:...
Mouse   921 IMSVKRPDVL-------------KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNP-------- 964

  Fly  2331 DDLGEDTENSTQSAEGNSKPVGYYVNRREHGIF--------PAPLPQNSEIC-ENVLKYFWFFGV 2386
                                  ||      |:|        ...:..||.:| |:.|.||.|.|.
Mouse   965 ----------------------YY------GLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGR 1001

  Fly  2387 FVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRT 2451
            .....:...:|:|......|.:::...::...:::.|.|:..|
Mouse  1002 VAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYN---------------------- 1044

  Fly  2452 DSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQN 2516
                        ||:.:.|.|||                  |.|.....::::
Mouse  1045 ------------SLKWILENDPT------------------ELDLMFCIDEEN------------ 1067

  Fly  2517 GLEVSLEDLALTFTYLPSSSIYGYT-QAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMK 2580
                                 :|.| |.:|.||||.:.||.:|...|.:|::.:...:.:.:||.
Mouse  1068 ---------------------FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMN 1111

  Fly  2581 AFSDGFNEVFPLKKLAAFTPSEARMMICG---EQFPHWSREDIISYTEPKLGYNKDSPGFQRFVN 2642
            ||.:||.|:.|:..:..|..:|..:::||   .....|.:..|.     |.||..:.|..|.|..
Mouse  1112 AFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIY-----KNGYCPNHPVIQWFWK 1171

  Fly  2643 VLLSMSGDERKAFLQFTTGCSSLPPGGLANLH----PRLTVVRKVDAGVGS---YPSVNTCVHYL 2700
            .:|.|..::|...|||.||.|.:|..|.|.|:    |:|..:.:    .||   .|..:||.:.|
Mouse  1172 AVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQ----WGSPEKLPRAHTCFNRL 1232

  Fly  2701 KLPDYPTEEIMKERLLTATKE-KGF 2724
            .||.|.|.|.::|:||.|.:. :||
Mouse  1233 DLPPYETFEDLREKLLMAVENAQGF 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	9/49 (18%)
		HECTc	2265..2725	CDD:238033	105/482 (22%)
Nedd4l	XP_036017204.1	PHA03378	<107..318	CDD:223065	2/4 (50%)
		C2	<367..420	CDD:417471	11/69 (16%)
		WW	465..491	CDD:395320	1/25 (4%)
		WW	655..684	CDD:395320	5/28 (18%)
		WW	768..798	CDD:238122	7/29 (24%)
		WW	817..867	CDD:197736	11/50 (22%)
		HECTc	928..1257	CDD:214523	102/471 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900