Protein Alignment Ufd4 and UPL4

DIOPT Version :10

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: NP_195908.1
• Gene: UPL4 / 831758
• AraportID: AT5G02880
• Length: 1502
• Species: Arabidopsis thaliana
• Alignment Length: 1377
• Identity: 331/1377 - (24%)
• Similarity: 545/1377 - (39%)
• Gaps: 359/1377 - (26%)

  Fly  1513 LSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLT-----ELSKENICRVLTPSYKPAESV 1572
            |..|..|:.:|::.......:.:..:..|..:|...:|.     ||:.....:.:..:|..:.||
plant   323 LINESTHLLNLNSRTTLSQPVYNGVIGMLRKLSSGSALAFRTLYELNIGYSLKEIMSTYDISHSV 387

  Fly  1573 TASQSSSHP----------------DVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLL-- 1619
                ||:||                ::..:||.|::  .:::.:|:..:|..:.:.:..:|:|
plant   388 ----SSTHPINACSNQVHEVLKLVIELLPASPVEDN--QLASEKESFLVNQPDLLQQFGRDMLPV 446

  Fly  1620 --------ANLRTSNIAGCPPVTQLST-EALEMIDKMRDGVDMIRNMSNS-----ILSTDTFPVP 1670
                    ||:..|  .||     ||. ..|..:.|..|.|::::|.:.|     |||.....|.
plant   447 MIQVLNSGANVYVS--YGC-----LSAIHKLTCLSKSGDIVELLKNTNMSSVLAGILSRKDHHVI 504

  Fly  1671 CTNVPVGGKKTPK-----------------AQALINPDNANQKQIIVTSEEFPT----------- 1707
            ...:.|......|                 .:||::.|...|.|......:.|.
plant   505 VVALQVAEVLLEKYRDTFLNSFIKEGVFFAIEALLSSDRGQQNQGSADLSQKPVTKEIVKCLCQS 569

  Fly  1708 --KSSKKPSVTLKPAQQPNAVLSIVDIKE------------------QPISNENVSVPSQMSI-- 1750
              :|....|.|.|..:....||: ..|||                  |.:.|.:|::...|::
plant   570 FERSLSSSSQTCKIEKDSVYVLA-TRIKEGFFGPEVFNSEKGLTDVLQNLKNLSVALSELMTVPI 633

  Fly  1751 -----------SVPN--LTTTSASEVPSTSEVATHTGLLETFAA-----IARRRTSQGTNIQDNQ 1797
                       |:.|  :...:..|..||.|. ..:|::::.|:     :.:|:.|:|
plant   634 DAHVLHDEKFFSIWNQIMERLNGRESVSTFEF-IESGVVKSLASYLSNGLYQRKLSKG------- 690

  Fly  1798 IMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPS--- 1859
                       |.:..|..|:|.......:|..|....:..|...:...||||..:..|..|
plant   691 -----------GPECDSLPFIGKRFEVFTRLLWSDGEATSSLLIQKLQNSLSSLENFPIVLSQFL 744

  Fly  1860 NPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDM------DE 1918
            ...|:.|...:....::. .:.:....::.| .||.|:.:.......|..||..|..      .|
plant   745 KQKNSFAAIPNGRCTSYP-CLKVRFLKAEGE-TSLRDYSQDFVTVDPLCYLDAVDQYLWPKVNIE 807

  Fly  1919 DNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPA 1983
            ..|..|.:|:..|..::.||                                   ....|....:
plant   808 PIDSVEAKDQAIECQSSQLQ-----------------------------------STSISCQAES 837

  Fly  1984 FDPRPGRTNVNQTSDLEISPL--GAELPKPQQSGGPETIEQ-----PLLGLKLRGPGIGGIPEVE 2041
            ..|....:..:..|.|:.|.:  ..:||..|.:...||..:     |.|..:|.|        :|
plant   838 SSPMEIDSESSDASQLQGSQVEDQTQLPGQQNASSSETSSEKEDAVPRLLFRLEG--------LE 894

  Fly  2042 IDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPT--------YTIVYREVSPEAQEST----- 2093
            :|.|   .|:::|:          .|.|.:...|.|        :.|.| |.|.:..:|.
plant   895 LDRS---LTVYQAI----------LLHKLKSESEATNDSKLSGPHNITY-ERSAQLGDSRENLFP 945

  Fly  2094 --CLESEEF-PQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQ----- 2150
              .:|.:|: |....:.:...|..|..:|  |..:           |:|.||..:.|:|:
plant   946 PGSMEDDEYRPFLSYLFTHRLALRLKGSS--HPPY-----------DILFLLKSLEGMNRFLFHL 997

  Fly  2151 --------------SEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENL 2201
                          ..:| |::.. |..:....|:|.|:|.||:||::|...:::..||.|..:|
plant   998 ISLERINAFGEGRLENLD-DLRVQ-VRPVPHSEFVSSKLTEKLEQQLRDSFAVSTCGLPPWFNDL 1060

  Fly  2202 NQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHER 2266
            ..|||.||.||.:..||...:||:.:.....|......|..:..|:           .|.|..::
plant  1061 MDSCPCLFSFEAKSKYFRLAAFGSQKIRHHPQHLSSSNVHGEARPV-----------TGSLPRKK 1114

  Fly  2267 VKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWL--C 2329
            ....| |::|..|.::|:.:.|:|.|:|||:.:|.|||||||||||.||:...|..||.||.  |
plant  1115 FLACR-ENILESAAKMMELYGNQKVVIEVEYSEEVGTGLGPTLEFYTLVSRAFQNPDLGMWRNDC 1178

  Fly  2330 DDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQD 2394
            ...:|:..|:|...|..:             |:||.|. ..:....:||:.|...|..|||.|||
plant  1179 SFIVGKPVEHSGVLASSS-------------GLFPRPW-SGTSTTSDVLQKFVLLGTVVAKALQD 1229

  Fly  2395 MRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAF 2459
            .|::|:|||.:|.:|:                                                .
plant  1230 GRVLDLPLSKAFYKLI------------------------------------------------L 1246

  Fly  2460 GGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLED 2524
            |..||..::..:||...:.|.|:|.|:.||:........|...|.:|       :.:|.::  ||
plant  1247 GQELSSFDIHFVDPELCKTLVELQALVRRKKLFAEAHGDSGAAKCDL-------SFHGTKI--ED 1302

  Fly  2525 LALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEV 2589
            |.|.|. ||     |||..:|.|..::..|.:||||.|.:.::|..:.:||.:|::||..|||:|
plant  1303 LCLEFA-LP-----GYTDYDLAPYSANDMVNLDNLEEYIKGIVNATVCNGIQKQVEAFRSGFNQV 1361

  Fly  2590 FPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKA 2654
            |.::.|..|...|...|:||| ...:|..:::.:.:...||...||..:..:.:|.....::::|
plant  1362 FSIEHLRIFNEEELETMLCGE-CDLFSMNEVLDHIKFDHGYTSSSPPVEYLLQILHEFDREQQRA 1425

  Fly  2655 FLQFTTGCSSLPPGGLANLHPRLTVVRK--VDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLT 2717
            ||||.||...||.||||:|.|:||:|||  .|:.....|||.||.:|||||.|.::|.|||:|:.
plant  1426 FLQFVTGSPRLPHGGLASLSPKLTIVRKHGSDSSDTDLPSVMTCANYLKLPPYSSKEKMKEKLIY 1490

  Fly  2718 A-TKEKG-FHLN 2727
            | |:.:| |||:
plant  1491 AITEGQGSFHLS 1502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANKYR	<375..>509	CDD:440430
		ANK repeat	393..420	CDD:293786
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		Sad1_UNC	1173..1298	CDD:474037
		MIB_HERC2	1333..1390	CDD:461991
		HECTc	2265..2725	CDD:238033	153/465 (33%)
UPL4	NP_195908.1	SRP1	85..>329	CDD:227396	2/5 (40%)
		armadillo repeat	156..181	CDD:293788
		armadillo repeat	189..226	CDD:293788
		armadillo repeat	230..263	CDD:293788
		HEAT repeat	277..303	CDD:293787
		HECTc	1114..1500	CDD:238033	153/464 (33%)