DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and KAK

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001329354.1	Gene:	KAK / 830017	AraportID:	AT4G38600	Length:	1888	Species:	Arabidopsis thaliana

Alignment Length:	2803	Identity:	587/2803 - (20%)
Similarity:	904/2803 - (32%)	Gaps:	1230/2803 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ERDMQLIALEQLCMLL-------LMSDNVDRCFESCPPRTFLPALCKIFLDELAPENVLEVTARA 77
            |...|:.||.|||.:|       |.:.:||         :|:|.|..:...|..|: ::.:.|||
plant   207 EEGKQVEALTQLCEMLSIGTEDSLSTFSVD---------SFVPVLVGLLNHESNPD-IMLLAARA 261

  Fly    78 ITYYLDVSAECTRRIVSIDGAIKAICNHLVVADLSSRTSRDLAEQCIKVLELICTREAGAVFEGG 142
            :|:..||.......:|.. ||:..:     ||.|.:....|||||.::.|:.|......|....|
plant   262 LTHLCDVLPSSCAAVVHY-GAVSCL-----VARLLTIEYMDLAEQSLQALKKISQEHPTACLRAG 320

  Fly   143 GLNCVLSFIRDCGSQVHKDTLHSAMSVVSRLCTKVEPN-TPCIQNCVESLSTLLQHEDPMVSDGA 206
            .|..|||::....:.|.:    .|:|..:.:|.|:..: :..:...|..|:.|||:.|..|.:.|
plant   321 ALMAVLSYLDFFSTGVQR----VALSTAANMCKKLPSDASDYVMEAVPLLTNLLQYHDSKVLEYA 381

  Fly   207 LKCFASVADRFTRKWVDPAP-----LAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTSSSQPAA 266
            ..|...:|:.|.     |.|     |..:||.|:                 ||....||:|.
plant   382 SICLTRIAEAFA-----PYPEKLDELCNHGLVTQ-----------------AASLISTSNSG--- 421

  Fly   267 TTNSDAINENVAGTATISNST-----KVKSSDAAASPQSISTTISLLSTLCRGSPSITHDIL--- 323
                       .|.|::|.||     ::.|:.|:.||....|.:.|      |..||..|||
plant   422 -----------GGQASLSVSTYTGLIRLLSTCASGSPLGFRTLLLL------GISSILKDILLGS 469

  Fly   324 ----RSQLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNT 384
                .:.::.||.|  ..|:  :.:.:..|:.||..|.||..:|...:|
plant   470 GVSANASVSPALSR--PADQ--IYEIVNLANELLPPLPEGVISLPTSTN---------------- 514

  Fly   385 NTDRTHRQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADV 449
                                                                .:|:..|:|
plant   515 ----------------------------------------------------ALVKGSCQK---- 523

  Fly   450 NKGQRSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGE 514
             |...|:|                   |     :.||                     ||:
plant   524 -KSSPSTS-------------------G-----KQED---------------------ILK---- 538

  Fly   515 WMSPDHSLLNKDGKKYTLMEPRGD-PEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKKIVQ 578
             :||...||             || ||:...:...|||:..:.:..|:.|::|...|::|.|::.
plant   539 -ISPREKLL-------------GDQPELLQQFGLDLLPVLVQIYGSSVNGTIRHKCLSVIGKLMY 589

  Fly   579 YAYPTVLQSL-SETSFSEDAASTSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIEEIMCKTQE 642
            ::...::||| .:|:.|...|.........:|:.                 .|.:.|.:|.|..|
plant   590 FSSSEMIQSLIGDTNISSFLAGVLAWKDPQVLVP-----------------ALQVAEILMEKLPE 637

  Fly   643 EFLDHFARLGVFAKVQALMDTDAEELYVQLPGTVEEPAAAQRSSTSVVVAPRPTSDDPMEDAKEI 707
            .|...|.|.||...|..|                                              :
plant   638 TFSKVFVREGVVHAVDQL----------------------------------------------V 656

  Fly   708 LQGKPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSEN 772
            |.|||.|.....  :..||:            .||....|:       ...||.:..:||.|.|.
plant   657 LVGKPSHASPTD--KDNDCV------------PGSARSRRY-------RRRSSNANSDGNQSEEP 700

  Fly   773 RGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTV-LQDD 836
            :        ...|..|....:....||||   .::...|....|..:.:...::|..|.| :.||
plant   701 K--------NPASLTIGANHNSLDTPTAS---FMLRETVSSCAKAFKDKYFPSDGGDVDVGVTDD 754

  Fly   837 LPGFIFESNRGTKHTFSAETVLGPDFASGWSTAK-KKRNKSKTEGQKFQVRNLSREIYNKYFKSA 900
            |   :...|..||.|            :|....| |.:.|||..|......:.|:|.|
plant   755 L---LHLKNLCTKLT------------AGIDDHKVKGKGKSKASGPFLGDFSASKEEY------- 797

  Fly   901 QIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSGLV 965
                      |..::.:|                         |.::...|| ||.:|...||:|
plant   798 ----------LIGVISEI-------------------------LGEISKGDG-VSTFEFIGSGVV 826

  Fly   966 QALVAVLSVNHW------ETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQ 1024
            .||:...|..::      |.|.|:.::..:  :|...|.:..|..:.......|.|     :|||
plant   827 AALLNYFSCGYFSKEKISELNLPKLRQEGL--RRFKAFLEVALPFDGNEGKVPPMT-----VLIQ 884

  Fly  1025 KLVSVLESTEKLPVYLYDSPCTGYS--------LQILQKRLRFRLERAECESTLFDRSGRTLKME 1081
            ||.:.|.|.|:.||.| ..|....|        |..|...|:.||.||..|.||.|.|...:.::
plant   885 KLQNALSSLERFPVVL-SHPSRSLSGSARLSSGLSALAHPLKLRLCRASGEKTLRDYSSNIVLID 948

  Fly  1082 PLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTC 1146
            |||::..:.::|       |..:.||                        |..|
plant   949 PLASLAAVEEFL-------WPRVQRS------------------------ESAL----------- 971

  Fly  1147 DWVNPAQYGLVQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLR 1211
               .||    ..:.::|..|||.|  ..:.|..|.:                      |.:.|.|
plant   972 ---KPA----APIGNTEPGTLPSG--AGVSSPSSST----------------------PASTTRR 1005

  Fly  1212 HARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQN 1276
            |: ...|||:                   ::.|.|..:|                      :.:.
plant  1006 HS-SRSRSAI-------------------NIGDTSKKDP----------------------VHEK 1028

  Fly  1277 GRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVD 1341
            |.::|             .|:..||       :|.|:|
plant  1029 GTSSS-------------KGKGKGV-------MKPAQA--------------------------- 1046

  Fly  1342 WRWEEQDGCAEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSA 1406

plant  1047 ----------------------------------------------------------------- 1046

  Fly  1407 STAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASA 1471
                   :||                        |:..||        |.|:.|
plant  1047 -------DKG------------------------PQTRSN--------AQKRAV----------- 1061

  Fly  1472 KTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINSS 1536
                                          :.||
plant  1062 ------------------------------LDKD------------------------------- 1065

  Fly  1537 NVSDLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEE 1601
                          |::             |||    :..|||..:....||  .||.:...|||
plant  1066 --------------TQM-------------KPA----SGDSSSEDEELEISP--VDIDDALVIEE 1097

  Fly  1602 NNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDT 1666
            ::          ||.|                                     .:..|..:..|:
plant  1098 DD----------ISDD-------------------------------------EDDDNEDVLDDS 1115

  Fly  1667 FPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVD 1731
            .|: ||                 ||..:                                    |
plant  1116 LPM-CT-----------------PDKVH------------------------------------D 1126

  Fly  1732 IKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDN 1796
            :|...            |:....|.|:.....|::...:.        ||.||...|..|.|.
plant  1127 VKLAD------------SVDDDGLATSGRQMNPASGGTSG--------AAAARASDSIDTGIG-- 1169

  Fly  1797 QIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNP 1861
                     |.:|.:.|    |..:..::..|..:|.  .|:..:...:....:.:|:.  ||..
plant  1170 ---------NSYGSRGA----LSFAAAAMAGLGAASG--RGIRGSRDLHGRTLNRSSDE--PSKL 1217

  Fly  1862 SNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENE 1926
            ..|:||:|        |:..||...:...|:.|                 ||||
plant  1218 IFTAAGKQ--------LSRHLTIYQAVQRQLML-----------------DEDD----------- 1246

  Fly  1927 DEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRT 1991
                                                     ||.|
plant  1247 -----------------------------------------DDRF-------------------- 1250

  Fly  1992 NVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQ 2056
                                   ||.                         ||.::|.:.|..:
plant  1251 -----------------------GGS-------------------------DLVSSDGSRFNDI- 1266

  Fly  2057 ELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPM 2121
                                 |||:|:.  |::|.:..........||..|:||..:..|..|..
plant  1267 ---------------------YTIMYQR--PDSQVNRLSVGGASSTTPSKSTKSATTNSSVESQS 1308

  Fly  2122 HIGFNVADNNL-----CSVD------DVLELLTQINGLNQ------SEIDSDVKEHGVSVLSEDL 2169
            |.. ::.|:.|     |.::      :||.||..:.||||      ::..||....|.....:||
plant  1309 HRA-SLLDSILQGELPCDLEKSNSTYNVLALLRVLEGLNQLCPRLRAQTLSDRFAEGKITSLDDL 1372

  Fly  2170 -----------FISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSF 2223
                       |::.|:|.||.:||||.|.|.|.:||:||..|.::|||||||:||:.||..|:|
plant  1373 STTAAKVPLDEFVNSKLTPKLARQIQDALALCSGSLPSWCYQLTRACPFLFPFQTRRQYFYSTAF 1437

  Fly  2224 GASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCN 2288
            |.||::..||.|:...        .|...::.|.|||||:.::|:|.||. :|..|.:||:.:.:
plant  1438 GLSRALNRLQQQQGAD--------GSGSTNEREMRIGRLQRQKVRVSRNR-ILDSAAKVMEMYSS 1493

  Fly  2289 RKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDD------DLGED-TENSTQSAEG 2346
            :|:|||||:..|.|||||||||||.|::.::|::.|.||....      .:|.| .|:...||..
plant  1494 QKAVLEVEYFGEVGTGLGPTLEFYTLLSHDLQKASLGMWRSSSGDKVSMQIGRDEIEDGKPSAAN 1558

  Fly  2347 NS---KPVGYYVNRREHGIFPAPLPQNSEICE-----NVLKYFWFFGVFVAKVLQDMRLVDIPLS 2403
            ..   .|:         |:||.|.|..::|.|     .|::||...|..:||.|||.||:|:|||
plant  1559 RDIVLAPL---------GLFPRPWPSTADISEGGQFHKVIEYFRLLGRVMAKALQDGRLLDVPLS 1614

  Fly  2404 TSFLQLLCHNKVLSRNLQKVISDRRNGDL-SVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLEN 2467
            |:|.:|     :|.:.|          || .:|..|:::.:|
plant  1615 TAFYKL-----ILGQEL----------DLHDIVLFDAELGKT----------------------- 1641

  Fly  2468 LKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYL 2532
                       |||::.::.||..:|   .:..:.. ..|::|.|:   |..:  |||:|.|| |
plant  1642 -----------LQELRVVVARKHYLE---GVGGDNS-STISDLCLR---GCRI--EDLSLEFT-L 1685

  Fly  2533 PSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAA 2597
            |     ||.: .:|.:|..: |.|.|||.|..|:::..::.|:.:|::||..|||:||.:..|..
plant  1686 P-----GYPE-YILRSGDEI-VDITNLEEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQI 1743

  Fly  2598 FTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGC 2662
            |||||...::||.: ..|..|.:..:.:...|||..||.....:.::..::.|:::||.||.||.
plant  1744 FTPSELDYLLCGRR-ELWEVETLAEHIKFDHGYNAKSPAIINLLEIMGELTADQQRAFCQFVTGA 1807

  Fly  2663 SSLPPGGLANLHPRLTVVRKVDA-------GVGS-------YPSVNTCVHYLKLPDYPTEEIMKE 2713
            ..|||||||.|:|:||:|||..:       |.|:       .|||.||.:|||||.|.|:|||.:
plant  1808 PRLPPGGLAVLNPKLTIVRKHSSTSSAAANGAGASETADDDLPSVMTCANYLKLPPYSTKEIMYK 1872

  Fly  2714 RLLTATKE 2721
            :||.|..|
plant  1873 KLLYAINE 1880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	0/26 (0%)
		ANK	396..509	CDD:238125	9/112 (8%)
		ANK repeat	422..453	CDD:293786	4/30 (13%)
		ANK repeat	455..484	CDD:293786	3/28 (11%)
		F5_F8_type_C	1173..1298	CDD:329041	15/124 (12%)
		MIB_HERC2	1333..1389	CDD:310955	0/55 (0%)
		DamX	1576..>1725	CDD:330571	20/148 (14%)
		HECTc	2265..2725	CDD:238033	164/487 (34%)
KAK	NP_001329354.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2761
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45670
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880