DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and WWC2

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_011530571.1 Gene:WWC2 / 80014 HGNCID:24148 Length:1216 Species:Homo sapiens


Alignment Length:1191 Identity:206/1191 - (17%)
Similarity:399/1191 - (33%) Gaps:320/1191 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1131 DEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSE--GKTLPYG------KLEDILSRDSISLNCHT 1187
            |.:|.:|||..|.:...|::|.......::.::  |..||:|      ....:...|.|:.....
Human    21 DYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQI 85

  Fly  1188 KDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGS 1252
            :|.:|.|                   ||.....|::: |..::|.........||.::.|.    
Human    86 EDPRKQW-------------------RGEQEKMLKDY-LSVAQDALRTQKELYHVKEQRLA---- 126

  Fly  1253 TATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKT- 1316
                   .|.|:     ::|:....:..| .:|....||       ...:......:.:||..| 
Human   127 -------LALDE-----YVRLNDAYKEKS-SSHTSLFSG-------SSSSTKYDPDILKAEISTT 171

  Fly  1317 -------RRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDHGVRN 1374
                   :||..|::.:|.:...|...::.:|   ::..|...|....|......::|   .:|.
Human   172 RLRVKKLKRELSQMKQELLYKEQGFETLQQID---KKMSGGQSGYELSEAKAILTELK---SIRK 230

  Fly  1375 SYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKS-------------- 1425
            :...|.:.|.||..:..:....|..:|::|.:....:.|....:...||::              
Human   231 AISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIG 295

  Fly  1426 -SSTPSLPEATEKNQNPEGASNQTVS-------ADNLAWKQTVETIAENVFASAKTQIISNQLAM 1482
             .|..:|.|....:...|.|.....:       .|:.||...::...|.:....:.:.:..:|..
Human   296 VRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQF 360

  Fly  1483 NTSSSR-EARAKHKESGTNQMHKDNIS---GPS--------------PLSRELEHISDLSA-INN 1528
            .|...| :...:..|:...::.::.:|   .||              .|.::||..:.|:. :::
Human   361 VTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHS 425

  Fly  1529 SMPAINSSNVSDLATISENLSLTEL-----SKENICRVLTPSYKPAESVTASQSSS-HPDVQ--- 1584
            .:.::::|.:|    :|...||..|     |.....|....|....|...:|||.. ..|.|   
Human   426 QLKSLSASTLS----MSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKL 486

  Fly  1585 -----------SSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLST 1638
                       .|.|       |:.|.||..:   .|.::..:..|..:..:.....||:.:...
Human   487 DFLLQEKSGYIPSGP-------ITTIHENEVV---KSPSQPGQSGLCGVAAAATGHTPPLAEAPK 541

  Fly  1639 EALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNAN--------- 1694
            ....:  ..|..:..:....:.::...|||:..::           .|.::...|:         
Human   542 SVASL--SSRSSLSSLSPPGSPLVLEGTFPMSSSH-----------DASLHQFTADFEDCELSSH 593

  Fly  1695 -------QKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISV 1752
                   :.||::.|:......|......|....:........|:::        |:|.:..|.:
Human   594 FADISLIENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEK--------SLPKRRVIHL 650

  Fly  1753 PNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSF 1817
            ....||..|...|...||..:|:.|.|       ..|.:.::|......:..:.|.........:
Human   651 LGEKTTCVSAAVSDESVAGDSGVYEAF-------VKQPSEMEDVTYSEEDVAIVETAQVQIGLRY 708

  Fly  1818 LGHSVTSLVKLALSSNFHSGLL-STAQSY------PSLSSNN----------SENIAPSNPSNTS 1865
            ...|.:.:|.:|...|.|:.|: .|::.|      ||.:..:          :|:|..::....:
Human   709 NAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVA 773

  Fly  1866 AGQQSASTINHTLTMSLTSTSSD-------SEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEE 1923
            ..|.:..  ..||.:.|.|.|..       ..|:||.|...|.....|..:|.....|....:||
Human   774 ISQTALQ--QKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEE 836

  Fly  1924 ENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRP 1988
            ..:..::.          ::.|:..:|.:|:                       |||:       
Human   837 NEDSVFQP----------NQPLVDSIDLDAV-----------------------SALL------- 861

  Fly  1989 GRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDW--TI 2051
            .||:.      |:..:..||.:.::....:  |:|      |||             :.||  |.
Human   862 ARTSA------ELLAVEQELAQEEEEESGQ--EEP------RGP-------------DGDWLNTY 899

  Fly  2052 FRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPE-----------AQESTCLESEEFPQTPD 2105
            |....||       |.|.|.::.......:.||.|.|           .::|:|        |.|
Human   900 FLCCWEL-------KDDVFTRLTVKPLLTMLREASDEIVAEKEAEVKLPEDSSC--------TED 949

  Fly  2106 VSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLF 2170
            :||.:....::.:.      |..::| |:.|...:..|:|..|...|.::|      ...::::.
Human   950 LSSCTSVPEMNEDG------NRKESN-CAKDLRSQPPTRIPTLVDKETNTD------EAANDNMA 1001

  Fly  2171 ISKKITNKLQQQIQDPLVLAS 2191
            :..|..:.|..: |.|.|.:|
Human  1002 VRPKERSSLSSR-QHPFVRSS 1021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 20/124 (16%)
MIB_HERC2 1333..1389 CDD:310955 11/55 (20%)
DamX 1576..>1725 CDD:330571 25/179 (14%)
HECTc 2265..2725 CDD:238033
WWC2XP_011530571.1 WW 12..41 CDD:278809 7/19 (37%)
WW 59..88 CDD:278809 5/28 (18%)
DUF342 <283..385 CDD:302792 13/101 (13%)
YlqD 351..>428 CDD:287979 11/76 (14%)
C2_Kibra 700..823 CDD:176062 24/124 (19%)
vWFA <1058..>1153 CDD:294047
Phage_Nu1 <1117..1192 CDD:294991
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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