DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufd4 and MAGIX

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_079135.3	Gene:	MAGIX / 79917	HGNCID:	30006	Length:	334	Species:	Homo sapiens

Alignment Length:	378	Identity:	76/378 - (20%)
Similarity:	119/378 - (31%)	Gaps:	110/378 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 PMVSDGALKCFASVADR--FTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTSSS 262
            |:....|.:..|.:..|  ..|..||.|.|......|..|:|.::|     |.|.:|..:.|.|.
Human    22 PLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAV-----SVLDSADIEVTDSR 81

  Fly   263 QPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRG------------- 314
            .|.||............|...........:.:|..|...|...|:  .|.||
Human    82 LPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQASGHFSV--ELVRGYAGFGLTLGGGRD 144

  Fly   315 ----SPSITHDILRSQLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQL 375
                :|.....:|:...|          :||  ..:...||:|.:..|..|.|
Human   145 VAGDTPLAVRGLLKDGPA----------QRC--GRLEVGDLVLHINGESTQGL------------ 185

  Fly   376 APRPRRNNTNTDRTHRQLIDCIRSKDSE---ALREAIES------GGIDVNCMDDVGQ----TLL 427
                         ||.|.::.||:...:   .:|..:|:      |         ||:    .:.
Human   186 -------------THAQAVERIRAGGPQLHLVIRRPLETHPGKPRG---------VGEPRKGVVP 228

  Fly   428 NWASAFGTLEMVEYLCEKGADVNKGQRSSSLHYAACFGRPAIAKILLKFGAYPDLRDE---DGKT 489
            :|.         :...:.|.....|.||||   .:....|.....|.|....|:...|   ||.|
Human   229 SWP---------DRSPDPGGPEVTGSRSSS---TSLVQHPPSRTTLKKTRGSPEPSPEAAADGPT 281

  Fly   490 PLDKARERLDDGHREVAAILQSPGEWMSPDHSLLNKDGKKYTLMEPRGDPEMA 542
             :.....|.:|.:.::..   |||.|:.|....|::      .:..||..::|
Human   282 -VSPPERRAEDPNDQIPG---SPGPWLVPSEERLSR------ALGVRGAAQLA 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	5/35 (14%)
		ANK	396..509	CDD:238125	24/128 (19%)
		ANK repeat	422..453	CDD:293786	4/34 (12%)
		ANK repeat	455..484	CDD:293786	7/28 (25%)
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033
MAGIX	NP_079135.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/3 (33%)
		PDZ_signaling	124..206	CDD:238492	20/120 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..306		25/121 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900