DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufd4 and ube3a

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	1058	Identity:	220/1058 - (20%)
Similarity:	359/1058 - (33%)	Gaps:	365/1058 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1806 NEHGDQNASGSFLG-----HSVTSLVKLALSSNF------HSGLLSTAQSYPSLSSNNSENIAPS 1859
            ||.....|.||..|     ::..::..|.|..|.      |......:.::|..|:..:.|.
Zfish    23 NEACTNEACGSSPGFQRMDNNAAAIKALELYKNNAKLCDPHPSKKGASSAFPENSAKGAHNF--- 84

  Fly  1860 NPSNTSAGQQSASTINHT---------LT-------MSLTSTSSDSEQV---------SLEDFLE 1899
              |..|.|:.:...:..|         ||       :|:.|.:.|...:         |.|..::
Zfish    85 --SACSNGKMNHKDLPPTREDFRDLNFLTEDKVYEILSICSETEDYSPLIRVIGRVFSSAESLVQ 147

  Fly  1900 SCRAPA--LLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVT 1962
            |.|...  ...:|......|||.||:|.|.  ....:|.::|          :.||..:...|.:
Zfish   148 SFRKAKQHTKEELKSLQAKDEDKDEDEKET--ASGSSTAMEV----------EPEASASSGDGSS 200

  Fly  1963 KRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGL 2027
            .                         |..||.:...:|:|   .::...::     ..::.|...
Zfish   201 H-------------------------GENNVQKLGPVEVS---VDIDAVRR-----VYDRLLSNE 232

  Fly  2028 KLRGPGIGGI----PEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPE 2088
            |:....:..:    |.||.||  |...::.|                    :|.|..|:..|
Zfish   233 KIEAAFLNALVYLSPNVECDL--TYHNVYAA--------------------DPNYLNVFIIV--- 272

  Fly  2089 AQESTCLESEEF-----PQTPDVSSKSGASTLSPNSPMHIGFNV--------------------- 2127
             .|::.|.|.|:     ||.....||.....|:..:.:...:.|
Zfish   273 -MENSNLHSPEYLEIALPQFCKAMSKLPLPALAKLARLWSQYGVDQIRRLVETFQQLITYTVISN 336

  Fly  2128 --ADNNLCSVDD-------VLELLTQINGL--------NQSEIDSDVKEHGVSVLSEDLFISKKI 2175
              :.:||.:.||       .|:::...|.|        |:.:.|..:.|.....|.|  .:.::.
Zfish   337 EFSSDNLVNEDDGVVAATKCLKIVYYANVLGGDLDTDHNEEDDDEPIPESSELTLQE--LLGEER 399

  Fly  2176 TNKLQQQIQDPLVLASNALPNWC------------ENLNQ----------------------SCP 2206
            .||...:: |||........:.|            |.||:                      :||
Zfish   400 RNKKGPRV-DPLETEMGIRASDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETESKFSFMTCP 463

  Fly  2207 FLFPFETRQL---YFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVK 2268
            |:....|:.|   |.|.....:.|.|..|.|    .|:.|:   ::|             :.|:|
Zfish   464 FILNAVTKNLGLYYDNRIRMYSERRITALYS----LVQGQQ---LNP-------------YLRLK 508

  Fly  2269 VPR----NEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWL 2328
            |.|    ::.|:...|..|:...:.|..|.|||..|:|... |.:.||:.||..||...|:.|:.
Zfish   509 VRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFT 573

  Fly  2329 CDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWF-------FGV 2386
            .|:        ||                                     |.|||       .|.
Zfish   574 YDE--------ST-------------------------------------KLFWFNPSSFENEGQ 593

  Fly  2387 FVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRT 2451
            |.        |:.|.|..:    :.:|.:|..:...||..:..|
Zfish   594 FT--------LIGIVLGLA----IYNNCILDVHFPMVIYRKLMG--------------------- 625

  Fly  2452 DSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQN 2516
               |...|      .:|.:..|..:|.|:::         :|::..:.
Zfish   626 ---KKGTF------RDLADSHPVLFQSLKDL---------MEYEGNVE----------------- 655

  Fly  2517 GLEVSLEDLALTFTYLPSSSIYGY-TQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMK 2580
                  ||:.:|| .:..:.::|. ...:|..:|..:.||.:|.:.:..|...::|...:.:|.|
Zfish   656 ------EDMMITF-QISQTDLFGNPLMYDLKESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFK 713

  Fly  2581 AFSDGFNEV---FPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVN 2642
            ||..||:.|   .|||.|  |.|.|..::|||.:  :...:.:...||...||||||...:.|..
Zfish   714 AFRRGFHMVTNESPLKYL--FRPEEIELLICGSR--NLDFQALEESTEYDGGYNKDSRIIRDFWE 774

  Fly  2643 VLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPT 2707
            .:.|...::::.|||||||....|.|||..|.   .::.|........|:.:||.:.|.||:|.|
Zfish   775 TVHSFEQEKKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDSDRLPTSHTCFNVLLLPEYST 836

  Fly  2708 EEIMKERLLTA-TKEKGF 2724
            .|.:|||||.| |..|||
Zfish   837 VEKLKERLLKAITYAKGF 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	118/477 (25%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166	9/36 (25%)
		HECTc	505..855	CDD:238033	118/477 (25%)
		HECTc	532..854	CDD:214523	109/448 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900