DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufd4 and Smurf1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006504947.1	Gene:	Smurf1 / 75788	MGIID:	1923038	Length:	757	Species:	Mus musculus

Alignment Length:	799	Identity:	169/799 - (21%)
Similarity:	257/799 - (32%)	Gaps:	268/799 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1985 DPRPGRTNVNQTSDLEISPLGAELPKPQQ----------SGGPETIEQP-----LLGLKLRGPGI 2034
            |..|||            ||...:.:|..          .|....:|.|     ||..:||.|.:
Mouse   165 DSGPGR------------PLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEV 217

  Fly  2035 GGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEE 2099
            .| |                    ||..| |:              .:...|||..|.....:..
Mouse   218 RG-P--------------------LQTPQ-NR--------------PHGHQSPELPEGYEQRTTV 246

  Fly  2100 FPQTPDVSSKSGASTL-SPNSPMHIGFNVADNNLCSVDD--VLELLTQ--------INGLNQSEI 2153
            ..|...:.:::|.||. .|..|..:|      .:...|:  :.|.|.|        :|.:|..|:
Mouse   247 QGQVYFLHTQTGVSTWHDPRIPSPLG------TIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDEL 305

  Fly  2154 DS-----DVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFET 2213
            ..     :|:.   :|.....|:..   |....|..||.:  .:.:.:.|:....|.|...|.|.
Mouse   306 GPLPPGWEVRS---TVSGRIYFVDH---NNRTTQFTDPRL--HHIMNHQCQLKEPSQPLQLPSEG 362

  Fly  2214 RQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRD--------DHEFRIGRLK--HERVK 2268
                                     :||.:.:|.....||        .||..:.:.:  |.|::
Mouse   363 -------------------------SVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIE 402

  Fly  2269 VPRNEDLLMWAMQVMKTH-CNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMW---LC 2329
            |.|.|.......|:||.. .:.|..|.|:|..|||..       |..||.|        |   ||
Mouse   403 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLD-------YGGVARE--------WLYLLC 452

  Fly  2330 DDDLGEDTENSTQSAEGNSKPVGYY--VNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVL 2392
            .:.|..                 ||  .......|:...:..:|.|..:.|.||.|.|
Mouse   453 HEMLNP-----------------YYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVG------- 493

  Fly  2393 QDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSN 2457
               |::.:        .:.|...:            ||..:        |....:||
Mouse   494 ---RIMGL--------AVFHGHYI------------NGGFT--------VPFYKQLL-------- 519

  Fly  2458 AFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSL 2522
              |..:.|.:|:.:||                               ||...|....:|.:...|
Mouse   520 --GKPIQLSDLESVDP-------------------------------ELHKSLVWILENDITPVL 551

  Fly  2523 EDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGF 2586
            :     .|:....:.:| ..|.||.|||.:|.||.:|.:.|..|.:|:....||..|..|...||
Mouse   552 D-----HTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGF 611

  Fly  2587 NEVFPLKKLAAFTPSEARMMICG---EQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMS 2648
            ||:.|...|..|...|..::|.|   .....|.....:.:..      .||...:.|...:.:..
Mouse   612 NELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCV------ADSNIVRWFWQAVETFD 670

  Fly  2649 GDERKAFLQFTTGCSSLPPGGLANLH-------PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYP 2706
            .:.|...|||.||.:.:|..|...|.       |||..:..:||...:.|..:||.:.:.:|.|.
Mouse   671 EERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYE 735

  Fly  2707 TEEIMKERLLTATKEK-GF 2724
            :.|.:.|:||||.:|. ||
Mouse   736 SYEKLYEKLLTAVEETCGF 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	110/478 (23%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028
		WW	236..267	CDD:197736	6/30 (20%)
		WW	307..339	CDD:197736	7/37 (19%)
		HECTc	399..754	CDD:238033	108/476 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900