DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Herc3

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001348895.1	Gene:	Herc3 / 73998	MGIID:	1921248	Length:	1050	Species:	Mus musculus

Alignment Length:	779	Identity:	155/779 - (19%)
Similarity:	241/779 - (30%)	Gaps:	329/779 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  2130 NNLCSVDDVLELLTQINGLNQSEIDSDVKEH--------GVS-----VLSEDL------FISKKI 2175
            ||..:|:.|:::|:.....|.|.::..:.||        |:.     :|.|.|      .|.::|
Mouse   418 NNANTVNGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRILFEKLMHSQHSMILEQI 482

  Fly  2176 TNKLQQ--------------------------QIQD---------PLVLA--------SNALPNW 2197
            .|..:.                          .:||         ||.:|        |..|.||
Mouse   483 LNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNW 547

  Fly  2198 CENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDH------- 2255
               .:|:||..|                 ..:|.|.....:.:.|.|...:.|...::
Mouse   548 ---WSQACPKYF-----------------MKLVTLYKGAVLYLLRGRKTFLIPVLFNNYMTATLK 592

  Fly  2256 --------EFRIGRLKHERVKVPR-------NEDLLMW--------------------------- 2278
                    ..::..:::::..:|.       .||.|||
Mouse   593 LLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQEDYLMWFLHQSGMKARPSIMQDAVTLCSYPFIF 657

  Fly  2279 ---------------AMQVMKTHCNRKSV------------------------------------ 2292
                           .|||.....|.::|
Mouse   658 DAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIH 722

  Fly  2293 --------LEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNS 2348
                    |:|.|..|||... |.|.||:.|:..|:                            .
Mouse   723 SDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKEL----------------------------L 759

  Fly  2349 KPVGYYVNRREHGIFPAPLPQN----SEICENVLKYFWF--FGVFVAKVLQDMRLVDI--PLSTS 2405
            .|:        :|:|......|    |:.|  .:::.||  .|:.....:.:..:||:  ||:
Mouse   760 NPI--------YGMFTYYQDSNLLWFSDTC--FVEHNWFHLIGITCGLAIYNSTVVDLHFPLA-- 812

  Fly  2406 FLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKE 2470
                          |.|                        |||....          |||:|||
Mouse   813 --------------LYK------------------------KLLNVKP----------SLEDLKE 829

  Fly  2471 IDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSS 2535
            :.||..:.|||:  |....:.||                             |...|.||....|
Mouse   830 LSPTEGRSLQEL--LDYPGEDIE-----------------------------ETFCLNFTVCRES 863

  Fly  2536 SIYG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFT 2599
              || ..|.:|:|.|..|.|..||.:.:.:..:|:|.|..:.:...|||.||.:|...|.|..|.
Mouse   864 --YGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQ 926

  Fly  2600 PSEARMMICGEQFPHWSR-EDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCS 2663
            |:|.|.|:.|.....|.. |:...|   :..|:...|..:.|.........:::|.||.|.||..
Mouse   927 PAELRAMMVGNSNYDWEELEETAVY---RGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSD 988

  Fly  2664 SLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE-KGFHL 2726
            .:|..|:|:|.   .:::....|....|..:||.:.|.||.|.::||||.||..|... :||.|
Mouse   989 RIPIYGMASLQ---IIIQSTATGEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	119/564 (21%)
Herc3	NP_001348895.1	ATS1	2..331	CDD:227511
		RCC1	313..377	CDD:366085
		HECTc	702..1048	CDD:238033	108/472 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900