DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Ubr5

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006520242.1	Gene:	Ubr5 / 70790	MGIID:	1918040	Length:	2800	Species:	Mus musculus

Alignment Length:	1611	Identity:	315/1611 - (19%)
Similarity:	536/1611 - (33%)	Gaps:	562/1611 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1323 IRAQLKHMTTGARVIRGVDWRWEEQDG----------CAEGTITGEIHNGWIDVKWDHGVRNSYR 1377
            ||...:...:.::.:||.|   ||||.          ..||....|.|:   |.:.:||..|:..
Mouse  1540 IRNPQQRRISQSQPVRGRD---EEQDDIVSADVEEVEVVEGVAGEEDHH---DEQEEHGEENAEA 1598

  Fly  1378 MGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPE 1442
            .|...::|...:|.|                           |....::.|.|..|:...||
Mouse  1599 EGHHDEHDEDGSDME---------------------------LDLLAAAETESDSESNHSNQ--- 1633

  Fly  1443 GASNQTVSADNLAWKQTVETIA---ENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHK 1504
                     ||.:.:::|.|.|   ....||:.....|...:.:..||        :|.::....
Mouse  1634 ---------DNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSS--------DSDSSSSQS 1681

  Fly  1505 DNISGPS-----PLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTP 1564
            |:|...:     ||.|                ..|||:.:..|....::...         |..|
Mouse  1682 DDIEQETFMLDEPLER----------------TTNSSHANGAAQAPRSMQWA---------VRNP 1721

  Fly  1565 SYKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAG 1629
            .::.|.| ||..|:|.|...|:        .:..|:.:| :..:.:::..:....|.|..||.:.
Mouse  1722 QHQRAAS-TAPSSTSTPAASSA--------GLIYIDPSN-LRRSGTISTSAAAAAAALEASNASS 1776

  Fly  1630 CPPVTQLSTEALE---MIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPD 1691
            .  :|..|:.|..   :|.::.|.:.:|...::.:.|         .:|...|.|  .|..:|..
Mouse  1777 Y--LTSASSLARAYSIVIRQISDLMGLIPKYNHLVYS---------QIPAAVKLT--YQDAVNLQ 1828

  Fly  1692 NANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPN-- 1754
            |..::::|.|.                     |.::|::|..|..: ....::.|......||
Mouse  1829 NYVEEKLIPTW---------------------NWMVSVMDSTEAQL-RYGSALASAGDPGHPNHP 1871

  Fly  1755 --LTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSF 1817
              .:..||.....|:........||     .|||.:         :::|     ..|..:|.|.|
Mouse  1872 LHASQNSARRERMTAREEASLRTLE-----GRRRAT---------LLSA-----RQGMMSARGDF 1917

  Fly  1818 LGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSL 1882
            |.::: ||::  ..::.||.:|      |.|...:.:::|           .....:.:.:....
Mouse  1918 LNYAL-SLMR--SHNDEHSDVL------PVLDVCSLKHVA-----------YVFQALIYWIKAMN 1962

  Fly  1883 TSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLT 1947
            ..|:.|:.|      ||..|...||     |..:|.::.|.||:|:..:...           |.
Mouse  1963 QQTTLDTPQ------LERKRTRELL-----ELGIDNEDSEHENDDDTSQSAT-----------LN 2005

  Fly  1948 FMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQ 2012
            ..||:::       ......:..|..:......:....|.|          .|: ||...:|...
Mouse  2006 DKDDDSL-------PAETGQNHPFFRRSDSMTFLGCIPPNP----------FEV-PLAEAIPLAD 2052

  Fly  2013 QSGGPETIE----------QPLLGLKLRGPGIGG-IPEVEIDLSNTDWTIFRAVQELLQCSQ--- 2063
            |   |..::          :|..||.....|.|. |.||.:|         |...|:|....
Mouse  2053 Q---PHLLQPNARKEDLFGRPSQGLYSSSAGSGKCIVEVTMD---------RNCLEVLPTKMSYA 2105

  Fly  2064 ------LNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMH 2122
                  :|..::.:|..|        |.|..|:|:.  .|:..|..|||:::..:|.|:     .
Mouse  2106 ANLKNVMNMQNRQKKEGE--------EQSLLAEEAD--SSKPGPSAPDVAAQLKSSLLA-----E 2155

  Fly  2123 IGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISK-KITNKLQQQI--Q 2184
            ||                 ||:..|...:.........|: |:|.|:.:.: :::.:|..::  :
Mouse  2156 IG-----------------LTESEGPPLTSFRPQCSFMGM-VISHDMLLGRWRLSLELFGRVFME 2202

  Fly  2185 DPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQ--RDVTVERQRIPI 2247
            |......:.|..           |..||.::..|.       |.:..|::|  ||:::|
Mouse  2203 DVGAEPGSILTE-----------LGGFEVKESKFR-------REMEKLRNQQSRDLSLE------ 2243

  Fly  2248 MSPRRDDHEFRIGRLKHERVKVPRNEDLLM-WAMQVMKTHCNRKSV--------LEVEFLDEEGT 2303
                               |||.|:.|||: ..|:.:..|..|:..        ::|.|.||.|.
Mouse  2244 -------------------VKVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGE 2289

  Fly  2304 GLGPTLEFYALVA-------------------------------------------AEIQRS--- 2322
            |.|....||..:|                                           .|::||
Mouse  2290 GSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGL 2354

  Fly  2323 ------DLCMWLCDDD----LGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENV 2377
                  |.     |.|    |..||.....::|||...            .|.|||.:.:.....
Mouse  2355 RAGSRRDR-----DRDFRRQLSIDTRPFRPASEGNPSD------------DPDPLPAHRQALGER 2402

  Fly  2378 L--KYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSR---NLQKVIS-DRRNG-----D 2431
            |  :.......|.:|:..  .|:::..:...|.|...:.:.:|   .::.:|: .|.||     |
Mouse  2403 LYPRVQAMQPAFASKITG--MLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILD 2465

  Fly  2432 LSVVSEDSDIVETCTK-----------LLRTDSNKSNA--------------------------- 2458
            |.::.....:.|...:           |..||....||
Mouse  2466 LGLLDSSEKVQENRKRHGSSRSVVDMDLEDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCF 2530

  Fly  2459 --FGGILSLENLKE---------------------------IDPTRYQFLQEMQNLLLRKQSIEF 2494
              .|.||.|..|:.                           .||..|:.|::   |:|..||.:.
Mouse  2531 RNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQ---LILASQSSDA 2592

  Fly  2495 DDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDN- 2558
            |...||                      .|||.........   |..|.||:|||.::.||..|
Mouse  2593 DAVFSA----------------------MDLAFAIDLCKEE---GGGQVELIPNGVNIPVTPQNV 2632

  Fly  2559 ---LEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMI--CGEQFPHWSRE 2618
               :..|.|..|..:.:    |.:.|...|..:|.|...|...|..:.|:::  |||.    :.:
Mouse  2633 YEYVRKYAEHRMLVVAE----QPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV----NVQ 2689

  Fly  2619 DIISYTEPKLGYNKDSP-------GFQR-FVNVLLSMSGDERKAFLQFTTGCSSLPPG--GLANL 2673
            .:||:|    .:|.:|.       .|:| |.:::..||..||:..:.|.|...|||..  |...:
Mouse  2690 MLISFT----SFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM 2750

  Fly  2674 HPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEKGF 2724
             |.:|:....|..:   |:.|||:..|.:|.|.:::|:|::||.|.|.|.|
Mouse  2751 -PSITIRPPDDQHL---PTANTCISRLYVPLYSSKQILKQKLLLAIKTKNF 2797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955	17/65 (26%)
		DamX	1576..>1725	CDD:330571	25/151 (17%)
		HECTc	2265..2725	CDD:238033	134/619 (22%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	11/64 (17%)
		HECTc	2469..2797	CDD:214523	84/371 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900