DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and SMURF2

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_073576.1	Gene:	SMURF2 / 64750	HGNCID:	16809	Length:	748	Species:	Homo sapiens

Alignment Length:	836	Identity:	175/836 - (20%)
Similarity:	288/836 - (34%)	Gaps:	248/836 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1967 WDDEFVLKRQFSALIPAFDPRPGRTNVNQTSD-----LEISPLGAELPKPQQSGGPETIE-QPLL 2025
            |:.:.:.|:|.:..:...  |.....:|:..|     |::..||     |..:   :|:. |.::
Human    80 WNHKKIHKKQGAGFLGCV--RLLSNAINRLKDTGYQRLDLCKLG-----PNDN---DTVRGQIVV 134

  Fly  2026 GLKLRGP-GIGGIPEVEIDLSN-------TDWTIFRAVQELLQCSQLNKLDKFRKIWE-PTYTIV 2081
            .|:.|.. |.||  :| :|.|.       ..|...|.....:|  .||.:.:..: || ||...
Human   135 SLQSRDRIGTGG--QV-VDCSRLFDNDLPDGWEERRTASGRIQ--YLNHITRTTQ-WERPTRPA- 192

  Fly  2082 YREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSP----------MHIGFNVADNNLCSVD 2136
             .|.|...:..:|...|..|    :|..:||:....:.|          .|..: ::..:|.:..
Human   193 -SEYSSPGRPLSCFVDENTP----ISGTNGATCGQSSDPRLAERRVRSQRHRNY-MSRTHLHTPP 251

  Fly  2137 DVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENL 2201
            |:.|...| ....|.::.....:.|||..                  .||.|      |....|:
Human   252 DLPEGYEQ-RTTQQGQVYFLHTQTGVSTW------------------HDPRV------PRDLSNI 291

  Fly  2202 NQSCPFLFPF---------ETRQLYF-----NCTSF---GASRSIVCLQSQRDVTVERQRIPIMS 2249
            |  |..|.|.         .|.::||     ..|.|   ..|.::..:.::::...::|:..::|
Human   292 N--CEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVS 354

  Fly  2250 PRRDDHE-FRIGRLKH---ERVKVPRNEDLLMWAMQVMKTHC----NRKSVLE------------ 2294
            ...||.| ..:.|.|.   :::|:.|.|   :...|....||    :|:.:.|
Human   355 LCPDDTECLTVPRYKRDLVQKLKILRQE---LSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPK 416

  Fly  2295 -------VEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVG 2352
                   ::|..|||..       |..||.|        ||           ...|.|..:...|
Human   417 DLWKRLMIKFRGEEGLD-------YGGVARE--------WL-----------YLLSHEMLNPYYG 455

  Fly  2353 YYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLS 2417
            .:...|: .|:...:..:|.:....|.||.|.|..:...:.....:|...:..|.:.|
Human   456 LFQYSRD-DIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQL------- 512

  Fly  2418 RNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEM 2482
                                                     .|..::|::::.:||
Human   513 -----------------------------------------LGKSITLDDMELVDP--------- 527

  Fly  2483 QNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELL 2546
                                  :|.|.|....:|.:...|:     .|:....:.|| ..|.||.
Human   528 ----------------------DLHNSLVWILENDITGVLD-----HTFCVEHNAYGEIIQHELK 565

  Fly  2547 PNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICG-- 2609
            |||.|:.|..:|.:.|..|.:|:....||..|..|...|||||.|...|..|...|..::|||
Human   566 PNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLG 630

  Fly  2610 -EQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANL 2673
             .....|.....:.:..|      ||...:.|...:.....:.|...|||.||.|.:|..|...|
Human   631 KIDVNDWKVNTRLKHCTP------DSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKAL 689

  Fly  2674 H----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEK-GF 2724
            .    |||..:.::||...:.|..:||.:.:.:|.|.:.|.:.|:||||.:|. ||
Human   690 QGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	106/492 (22%)
SMURF2	NP_073576.1	C2_Smurf-like	13..137	CDD:176028	12/66 (18%)
SMURF2	NP_073576.1	HUL4	<159..745	CDD:227354	153/742 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900