DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and HACE1

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_065822.2 Gene:HACE1 / 57531 HGNCID:21033 Length:909 Species:Homo sapiens


Alignment Length:1271 Identity:252/1271 - (19%)
Similarity:413/1271 - (32%) Gaps:478/1271 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1552 ELSKENICRVLTPSYKPAESVTASQSSS------HPDVQSSSPRENDIKNISNIEENNKMNANNS 1610
            |.:.|.:.| ||.|.:.|.:|...:.:.      .|.|.:...|     ::|.:..|:|.:.|.:
Human     2 ERAMEQLNR-LTRSLRRARTVELPEDNETAVYTLMPMVMADQHR-----SVSELLSNSKFDVNYA 60

  Fly  1611 VNKISKDLL-------------------ANLRTSNIAGCPP----------------------VT 1634
            ..::.:.||                   ||....:|:||.|                      |.
Human    61 FGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

  Fly  1635 QLSTEALEMIDKMR-DG-----VDMIRNMSN----SILSTDTFPVPCTNVPVGGKKTPKAQALIN 1689
            ..:.|.|..|..:. :|     .|:::::|:    ..:......|.|.|    |.||.....|.:
Human   126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQN----GHKTTVQCLLDS 186

  Fly  1690 PDNANQKQIIVTSEEFPTKSSKKP-SVTLKPAQQPNA-VLSIVDIKEQPISNENVSVPSQMSISV 1752
            ..:.|:          |..|...| .......|:..| :|.:...|..|  ::|...|..:.:. 
Human   187 GADINR----------PNVSGATPLYFACSHGQRDTAQILLLRGAKYLP--DKNGVTPLDLCVQ- 238

  Fly  1753 PNLTTTSASEVPSTSEVAT--HTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASG 1815
                    .....|.||..  |..|.:|..     :.:|..::::|.:    ..|.||..|.:..
Human   239 --------GGYGETCEVLIQYHPRLFQTII-----QMTQNEDLRENML----RQVLEHLSQQSES 286

  Fly  1816 SFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSN---------NSENIAPSNPSNTSAGQQSA 1871
            .:| ..:|||.::| ::|.|. |||.:.:|.:...:         :...|.||:|||        
Human   287 QYL-KILTSLAEVA-TTNGHK-LLSLSSNYDAQMKSLLRIVRMFCHVFRIGPSSPSN-------- 340

  Fly  1872 STINHTLTMSLTSTSSDSEQV---------SLEDFLESCRAPALLGDLDDEDDMDEDNDEEENED 1927
                 .:.|......:...||         ||:::|.......:                 :|:.
Human   341 -----GIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELM-----------------KNKR 383

  Fly  1928 EYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTN 1992
            :..|:.:.||                         |:|..|       |.:|.||.|:| ||..:
Human   384 DSTEITSILL-------------------------KQKGQD-------QDAASIPPFEP-PGPGS 415

  Fly  1993 VNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEID----LSNTDWTIFR 2053
            ....|      .|....||.                    .:.|..|...|    :|.|...:..
Human   416 YENLS------TGTRESKPD--------------------ALAGRQEASADCQDVISMTANRLSA 454

  Fly  2054 AVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPN 2118
            .:|....|                              .:|       |.|.          ...
Human   455 VIQAFYMC------------------------------CSC-------QMPP----------GMT 472

  Fly  2119 SPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQI 2183
            ||..|.|      :|..|:||:                            .|:::          
Human   473 SPRFIEF------VCKHDEVLK----------------------------CFVNR---------- 493

  Fly  2184 QDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIM 2248
             :|.::..:              |.|..|..:|        .||.:..:::|             
Human   494 -NPKIIFDH--------------FHFLLECPEL--------MSRFMHIIKAQ------------- 522

  Fly  2249 SPRRDDHEF-----RIGRLKHERVKVPRNE-DLLMWAMQ---------VMKTHCNR-KSVLEVEF 2297
             |.:|..|:     ..|:...:.|..|.|| |:|:....         |.|.:|.: |..:.|.|
Human   523 -PFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRF 586

  Fly  2298 LDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGI 2362
            ..|||.|.|...|::.:::.||...|..::             ||||:|.:    :..|      
Human   587 HGEEGMGQGVVREWFDILSNEIVNPDYALF-------------TQSADGTT----FQPN------ 628

  Fly  2363 FPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDR 2427
                  .||.:..:.|.||.|.|..:...|...:||:|..:.||.:   |...:..|.|.|.|  
Human   629 ------SNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYK---HILGIPVNYQDVAS-- 682

  Fly  2428 RNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSI 2492
                                                       |||   ::.:.:|.:|      
Human   683 -------------------------------------------IDP---EYAKNLQWIL------ 695

  Fly  2493 EFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTI 2556
              |:.||                        ||.|..|:...:.::| ..:..|.|.|.|:.||.
Human   696 --DNDIS------------------------DLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734

  Fly  2557 DNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDII 2621
            :|...|.:|:....:...|..|:.||..||:...|...:..|...|..:::.|  .|.....|.|
Human   735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSG--MPEIDVSDWI 797

  Fly  2622 SYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAG 2686
            ..||...||.::.|..|.|..|:..::.:||...|||.||.|.:|.||.||:.....:.....|.
Human   798 KNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAA 862

  Fly  2687 V----GSYPSVNTCVHYLKLPDYPTEEIMKERLLTA 2718
            |    ...|:.:||::.||||:||::||:|:|||.|
Human   863 VPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVA 898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041
MIB_HERC2 1333..1389 CDD:310955
DamX 1576..>1725 CDD:330571 34/206 (17%)
HECTc 2265..2725 CDD:238033 119/470 (25%)
HACE1NP_065822.2 Ank_2 <27..>283 CDD:330894 51/294 (17%)
ANK 1 64..93 4/28 (14%)
ANK repeat 66..95 CDD:293786 4/28 (14%)
ANK 92..217 CDD:238125 24/138 (17%)
ANK repeat 97..128 CDD:293786 4/30 (13%)
ANK 2 97..126 4/28 (14%)
ANK repeat 130..161 CDD:293786 6/30 (20%)
ANK 3 130..159 6/28 (21%)
ANK repeat 163..194 CDD:293786 8/44 (18%)
ANK 4 163..192 7/32 (22%)
ANK 5 196..226 7/31 (23%)
ANK repeat 196..221 CDD:293786 5/24 (21%)
ANK 6 228..257 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..433 13/68 (19%)
HECTc 554..903 CDD:238033 114/459 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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