DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and HECW2

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_006712709.1 Gene:HECW2 / 57520 HGNCID:29853 Length:1579 Species:Homo sapiens


Alignment Length:1954 Identity:362/1954 - (18%)
Similarity:635/1954 - (32%) Gaps:717/1954 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1061 LERAECESTLF---DRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTAT 1122
            |:||..::.|.   .||..|..|... |:||....::....|:  ::|.|.:..|..|.|:..| 
Human    43 LQRANSDTDLVTSESRSSLTASMYEY-TLGQAQNLIIFWDIKE--EVDPSDWIGLYHIDENSPA- 103

  Fly  1123 VFTHSFDFDEEGLLFYIGSNAKTCDW-VNPAQY-----------------GLVQVTS-------- 1161
               :.:|....|:   .|:......| :.|..|                 |.::.|:        
Human   104 ---NFWDSKNRGV---TGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNP 162

  Fly  1162 -----SEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSAL 1221
                 :||  :..|...::.||..:|.   |..:.:| ..:..|::..|..|.            
Human   163 AVMMGAEG--MEGGASGNLHSRKLVSF---TLSDLRA-VGLKKGMFFNPDPYL------------ 209

  Fly  1222 RNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCA-------------TDDSVWYRHIRI 1273
                                   |..::||..:::| .||             |.:.:|:|    
Human   210 -----------------------KMSIQPGKKSSFP-TCAHHGQERRSTIISNTTNPIWHR---- 246

  Fly  1274 QQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTR-----------------RERR 1321
                               |.|.....:.|.:...:|:..||:|                 .||:
Human   247 -------------------EKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQ 292

  Fly  1322 QIRAQLKHMTTGARV----IRGV-------------DWRWEEQDGCAE--GTITG---------- 1357
            .|..|:.....|.|:    :.|.             :..:...|...|  |||.|          
Human   293 AIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEEMLFSHSDASPEAVGTILGVNSVNGDLGS 357

  Fly  1358 ---------------EIHNGWI--DVKWDHGVRNSYRMGA-------------------EGKYDL 1386
                           ...||.:  |...|...::|:|..:                   .|:.| 
Human   358 PSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQD- 421

  Fly  1387 KLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTP----SLPEATEKN------QNP 1441
            .|.|  ||.|.:.|..          |..|..|.:.|...::|    |.|..|..|      .:.
Human   422 SLND--YLDAIEHNGH----------SRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDE 474

  Fly  1442 EGASNQTVSADNLAWKQTVE-----------TIAENVFASAKTQIISNQLAMNTSSSREARA-KH 1494
            |....|    .:|.:..::|           :.|::...:::|::..|.:....:|:.||.: :.
Human   475 EDHEFQ----QDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFED 535

  Fly  1495 KESGTNQMHKDNI-SGPSPLSRELEHISDLSAINNSMPAINSSNV------SDLAT--------- 1543
            |.....::.:.:: :||:|...|.......||...|.....|..|      :|..|         
Human   536 KPENLPELAESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRR 600

  Fly  1544 -ISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQS------SSPRENDIKNISNIEE 1601
             :||..||.:.|:.:.....|....||.:.:.|::|:.|:.:|      ||..|:....:|::: 
Human   601 AVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVD- 664

  Fly  1602 NNKMNANNSVNKISKDLLANLRTSNI--AGCPPVTQLSTEALEMIDKMRDGVDMIRNMSN----- 1659
                                .|.|::  |..|.....|::..|      ||.......|:     
Human   665 --------------------TRCSSLESARFPETPAFSSQEEE------DGACAAEPTSSGPAEG 703

  Fly  1660 ---SILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQI---------IVTSEEFPTK---S 1709
               |:.:..:.||  ..||.|..:.|.|::...||.....::         ...:.|.|.:   |
Human   704 SQESVCTAGSLPV--VQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGS 766

  Fly  1710 SKKPSVTLK--PAQQPNAVLSIVDIKEQPISN-----ENVSVPSQMSISVP-------------- 1753
            :.:...|.:  .||:..|.........||:.:     ::||...::..::|              
Human   767 AGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIF 831

  Fly  1754 -----NLTTT-SASEVPSTSEVATHTGLLETFAAIAR-----RRTSQGTNIQDNQIMNAEANVNE 1807
                 |.||| .....|...:|...:..::....:.|     |||.  ||.:..:..||.....|
Human   832 YVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTM--TNERPEENTNAIDGAGE 894

  Fly  1808 HGD-QNASGSF-----LGHS-----VTSL-----VKLALSSNFHSGLLSTAQSYPSLSSNNSENI 1856
            ..| ..||..|     |.||     :|.|     ||..:|..|.:.|.|...:|...::|     
Human   895 EADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNN----- 954

  Fly  1857 APSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDND 1921
                           :.:.|.:|.....|                                    
Human   955 ---------------TCLKHMITKVRRDT------------------------------------ 968

  Fly  1922 EEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWD-------DEFVLKRQFSA 1979
              .:.:.|:.          :|:|:.|::  ...|:.:.:.  :.|:       ..|.:... |.
Human   969 --HHFERYQH----------NRDLVGFLN--MFANKQLELP--RGWEMKHDHQGKAFFVDHN-SR 1016

  Fly  1980 LIPAFDPRPGRTNVNQTSDL--------EISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGG 2036
            .....|||....:...||.|        :.|....|:.:..:..||..:.:|             
Human  1017 TTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRP------------- 1068

  Fly  2037 IPEVEIDLSNTDWTIFR-AVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCL-ESEE 2099
                    |:|..|:.| ..|:::..:..:|:..|.:  :|....:.:|..|:...:..| |..:
Human  1069 --------SSTFNTVSRPQYQDMVPVAYNDKIVAFLR--QPNIFEILQERQPDLTRNHSLREKIQ 1123

  Fly  2100 FPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSV 2164
            |.:|   ....|...||.::                 |::.||:    |.:.||.|.|..|.:  
Human  1124 FIRT---EGTPGLVRLSSDA-----------------DLVMLLS----LFEEEIMSYVPPHAL-- 1162

  Fly  2165 LSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSI 2229
                                        ..|::|::...|     |..:.|     .|.|..|: 
Human  1163 ----------------------------LHPSYCQSPRGS-----PVSSPQ-----NSPGTQRA- 1188

  Fly  2230 VCLQSQRDVTVERQRIPIMSPRRDDHEFRI----------------GRLKHERVKVPRNEDLLMW 2278
                        ..|.|  :|.:.|.|.::                |:||    .:.|.:.||..
Human  1189 ------------NARAP--APYKRDFEAKLRNFYRKLETKGYGQGPGKLK----LIIRRDHLLED 1235

  Fly  2279 AMQVMKTHCNR---KSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTEN 2339
            |...:..:..:   ::.|.|.|:.|||... ||:.||:.||:.|:.....       .|.|.:.|
Human  1236 AFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYY-------GLFEYSAN 1293

  Fly  2340 STQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDI---- 2400
            .|.:.:  ..|:..:|                   :|..::|.|.|..:...|....|:|.    
Human  1294 DTYTVQ--ISPMSAFV-------------------DNHHEWFRFSGRILGLALIHQYLLDAFFTR 1337

  Fly  2401 PLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSL 2465
            |...:.|::||                   |||                                
Human  1338 PFYKALLRILC-------------------DLS-------------------------------- 1351

  Fly  2466 ENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFT 2530
             :|:.:|...:|.||.|:           |:.|     |::::                  ||||
Human  1352 -DLEYLDEEFHQSLQWMK-----------DNDI-----HDILD------------------LTFT 1381

  Fly  2531 YLPSSSIYG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKK 2594
            .  :..::| .|:.||.|.|:::.||..|.:.|.|.::.:.::.|:.||.::...||.||...:.
Human  1382 V--NEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARL 1444

  Fly  2595 LAAFTPSEARMMICGE---QFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFL 2656
            ::.|...|..::|.|.   ....|...     ||.:.||:.:....:.|...:...:.::|...|
Human  1445 VSVFDARELELVIAGTAEIDLSDWRNN-----TEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLL 1504

  Fly  2657 QFTTGCSSLPPGGLANLH----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLT 2717
            ||.||.||:|..|.|:|.    ||...|.|. ..:.:.|..:||.:.|.||.||:..::.|:|||
Human  1505 QFVTGTSSIPYEGFASLRGSNGPRRFCVEKW-GKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1568

  Fly  2718 ATKE 2721
            |.:|
Human  1569 AVEE 1572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 19/137 (14%)
MIB_HERC2 1333..1389 CDD:310955 17/120 (14%)
DamX 1576..>1725 CDD:330571 32/178 (18%)
HECTc 2265..2725 CDD:238033 108/473 (23%)
HECW2XP_006712709.1 HECW_N 45..164 CDD:318711 25/128 (20%)
C2_NEDL1-like 185..321 CDD:176073 29/198 (15%)
NESP55 <471..638 CDD:115071 32/170 (19%)
PHA03169 591..>801 CDD:223003 45/238 (19%)
WW 816..845 CDD:306827 5/28 (18%)
WW 994..1023 CDD:306827 3/31 (10%)
HECTc 1223..1577 CDD:238033 110/476 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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