Protein Alignment Ufd4 and SMURF1

DIOPT Version :9

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: NP_065162.1
• Gene: SMURF1 / 57154
• HGNCID: 16807
• Length: 757
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 126/576 - (21%)
• Similarity: 192/576 - (33%)
• Gaps: 177/576 - (30%)

  Fly  2177 NKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVE 2241
            |....|..||.:  .:.:.:.|:....|.|...|.|.                         ::|
Human   328 NNRTTQFTDPRL--HHIMNHQCQLKEPSQPLPLPSEG-------------------------SLE 365

  Fly  2242 RQRIPIMSPRRD--------DHEFRIGRLK--HERVKVPRNEDLLMWAMQVMKTH-CNRKSVLEV 2295
            .:.:|.....||        .||..:.:.:  |.|::|.|.|.......|:||.. .:.|..|.|
Human   366 DEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMV 430

  Fly  2296 EFLDEEGTGLGPTLEFYALVAAEIQRSDLCMW---LCDDDLGEDTENSTQSAEGNSKPVGYY--V 2355
            :|..|||..       |..||.|        |   ||.:.|..                 ||  .
Human   431 KFRGEEGLD-------YGGVARE--------WLYLLCHEMLNP-----------------YYGLF 463

  Fly  2356 NRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNL 2420
            ......|:...:..:|.|..:.|.||.|.|          |::.:        .:.|...:
Human   464 QYSTDNIYMLQINPDSSINPDHLSYFHFVG----------RIMGL--------AVFHGHYI---- 506

  Fly  2421 QKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNL 2485
                    ||..:        |....:||          |..:.|.:|:.:||
Human   507 --------NGGFT--------VPFYKQLL----------GKPIQLSDLESVDP------------ 533

  Fly  2486 LLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNG 2549
                               ||...|....:|.:...|:     .|:....:.:| ..|.||.|||
Human   534 -------------------ELHKSLVWILENDITPVLD-----HTFCVEHNAFGRILQHELKPNG 574

  Fly  2550 SSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICG---EQ 2611
            .:|.||.:|.:.|..|.:|:....||..|..|...||||:.|...|..|...|..::|.|   ..
Human   575 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 639

  Fly  2612 FPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLH-- 2674
            ...|.....:.:..      .||...:.|...:.:...:.|...|||.||.:.:|..|...|.
Human   640 LNDWKSNTRLKHCV------ADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 698

  Fly  2675 -----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEK-GF 2724
                 |||..:..:||...:.|..:||.:.:.:|.|.:.|.:.|:||||.:|. ||
Human   699 TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	110/478 (23%)
SMURF1	NP_065162.1	C2_Smurf-like	14..138	CDD:176028
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..237
		WW	236..267	CDD:197736
		WW	307..339	CDD:197736	4/10 (40%)
		HECTc	399..754	CDD:238033	108/476 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900