Protein Alignment Ufd4 and plekha7a

DIOPT Version :9

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: NP_001129715.1
• Gene: plekha7a / 571486
• ZFINID: ZDB-GENE-050419-75
• Length: 1197
• Species: Danio rerio
• Alignment Length: 982
• Identity: 187/982 - (19%)
• Similarity: 310/982 - (31%)
• Gaps: 341/982 - (34%)

  Fly  1681 TPKAQALINPDNAN-----QKQIIVTSEEFPTKSSKKPSVTLK---PAQQPNAVLSIVDIKEQPI 1737
            |.|.....:||:.|     :||.:..:....:....||.|...   |..:....:..|:|:..|.
Zfish   262 TVKRDECGHPDHVNVSEKLKKQAVPQTNHINSYVIPKPEVIQSDGLPEDKREGFVGEVEIQVTPR 326

  Fly  1738 SNENVSVPS------QMSISVPNLTTTS--ASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQ 1794
            ..|.....|      ::.:..|..|..|  ||..||.:        :.|...:.|    .||.|:
Zfish   327 EMEQARGKSPASRVVEVEVLAPGSTPPSRVASRAPSRA--------VSTPPVVQR----NGTPIE 379

  Fly  1795 DNQIMNAEANVNEHGD---QNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENI 1856
            .|.:...:........   |....|.| ..|.:.||  :......||:||..:.|       ...
Zfish   380 QNGMPGCQRGATPSAQTPVQVQRRSTL-EQVENWVK--VQKEERHGLVSTESTVP-------RRT 434

  Fly  1857 APSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDND 1921
            .|.:|...:..:.          .||..||..|             .||....|..|.....|
Zfish   435 PPIHPKYGTMDKY----------QSLPKTSRQS-------------PPAPHHQLPSEYKYSHD-- 474

  Fly  1922 EEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDD-------EFVLKRQF-- 1977
                                  .|..|       .::.|.|||.:..|       |:..::||
Zfish   475 ----------------------RLNHF-------QKIHGHTKRPTTHDNTVWQLFEWQQRQQFRH 510

  Fly  1978 -SALIPAFDPRPG--------RTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPG 2033
             |...|.:.|.|.        |.|.:.:..:.:.|..|::|.|    ||.       |.:|..|.
Zfish   511 GSPFAPVYTPAPDYSTAVSSTRNNPDVSRSVSVPPTLADIPPP----GPP-------GARLMSPR 564

  Fly  2034 IGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKF------RKIWEP----TYTIVYREVSPE 2088
            ....|...:.:...:   .|.:.|:...:..::|..:      |:...|    |:|:....:..:
Zfish   565 RPHTPAERVTVRPLE---DRPIVEVPPSNSPHRLRSYKSATIERRSMPPSAYITHTVSAPSLRGK 626

  Fly  2089 AQESTCLESEEFPQTPDVSSKSGASTLS--PNSPMHIGFNVAD---NNLCSVDDVL-ELLTQING 2147
            ..:.|.:..::..:..|: ..||...|.  |..|:.:..:..|   :.||..|.:| ||..:::|
Zfish   627 TADDTYMHLKKGLEYLDL-KVSGTEALKGRPAKPVKVAESDVDVTLSRLCEQDKILQELEFRLSG 690

  Fly  2148 LNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFE 2212
            |..   |.|..|   |||.        ::::..:|.:|.        |:..:.:        .::
Zfish   691 LKD---DKDKLE---SVLD--------VSHQQMEQYKDQ--------PSHTDKI--------AYQ 725

  Fly  2213 TRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLM 2277
            .|.|..:.....|..|.|..:.:|              ..||:.           .:.::.:.|.
Zfish   726 QRLLQEDLVHIRADISRVSTEMER--------------AWDDYS-----------GMEQSVEQLR 765

  Fly  2278 WAMQVMKTHC---NRKSVLEVEF--LDEEGTGLGPTLEFYALV---------------------- 2315
            ..:|...|.|   ..|:.|:.|.  :::..|||..|.|.:.:.
Zfish   766 DVLQTQMTLCTSPQEKNQLKRELWRMEDVMTGLSSTKETFKITVDSVKNPERKLVPSVIESTVPS 830

  Fly  2316 ------AAEI---QR----SDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFP-AP 2366
                  |||:   ||    |.|.:.|.::||            .|..||   .|..|....| .|
Zfish   831 RCMTPSAAEVRSPQRSLTSSPLSLPLDNEDL------------RNRHPV---PNWEEDDAPPRPP 880

  Fly  2367 LPQNSEICENVLKYFWFFGVFVAKVLQDMR----LVDIPLSTSFLQLLCHNKVLSRNLQKVISDR 2427
            ||                      :|.|..    :..:|..||.::   |..|  |.|::...:|
Zfish   881 LP----------------------LLYDEDTPPVVPPLPKETSVIR---HTSV--RGLKRQSDER 918

  Fly  2428 R--------NGD-------------LSVVSEDSDIVE------------------------TCTK 2447
            :        |||             |.|.:..:|.|:                        :|:
Zfish   919 KRDRESSYSNGDYRLELRSYLSEPELPVSAHGADHVDPGYLTLQRRGLSGSSSRINQYGVASCS- 982

  Fly  2448 LLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHE--LINEL 2510
             ||.|...|.......:||.|...:|   |..|:.|...:| .|:|  :.:...|:|:  |:.|.
Zfish   983 -LRRDLELSTMERPKSALERLCSGEP---QLEQQSQPQRVR-MSVE--EQLERMKRHQRALVRER 1040

  Fly  2511 KLQTQNG 2517
            |.....|
Zfish  1041 KRNLSQG 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	11/51 (22%)
		HECTc	2265..2725	CDD:238033	69/345 (20%)
plekha7a	NP_001129715.1	WW	55..84	CDD:278809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	98..148
		PH_PEPP1_2_3	153..256	CDD:270068
		PH	159..255	CDD:278594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..384		13/47 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..467		14/73 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	508..577		17/79 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..928		29/139 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1032..1064		5/16 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900