DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and plekha5

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_021330752.1	Gene:	plekha5 / 567300	ZFINID:	ZDB-GENE-041210-25	Length:	1398	Species:	Danio rerio

Alignment Length:	1444	Identity:	254/1444 - (17%)
Similarity:	426/1444 - (29%)	Gaps:	522/1444 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 PDFASGW-----STAKKKRNK---------------SKTEG-------QKFQVRNLSRE--IYNK 895
            |...:||     ||..|...|               .|.||       ..|.:..||.:  |..|
Zfish   182 PVIKNGWLHKQDSTGMKMWKKRWFVLSDMCLFYYRDEKEEGILGSILLPSFHISMLSVDDHITRK 246

  Fly   896 Y-FKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEM 959
            | ||:.....| .....||..|.:|            :|...::||.|..|:.|.....|..
Zfish   247 YAFKATHPNMR-TYYFSTDTAKDME------------SWMKVMSDAAMAHSEPIRRLEKVKL--- 295

  Fly   960 HSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKP----------- 1013
             .|.:.|.:..:|  ||.....|..:.|:..::.:.      .||.....:.||
Zfish   296 -DSRVPQEMNNML--NHRVLTRPEIQNNERNRETLR------QEDKKSKPSEKPQKDKDRVSMQK 351

  Fly  1014 -----------RTKSTASILIQKLVS--VLEST-EKLPV---------------YLYDSPCTGYS 1049
                       |.|.....::||.:.  ||:.. ||..|               |........|:
Zfish   352 DGERFSENYTHRQKDGERYMLQKDLEKFVLQKDGEKYAVQKEGDKYLLQKDGHKYTVHKDGDKYT 416

  Fly  1050 LQ--------------ILQKRLRFRLERAECESTL----------FDRSG---------RTLKME 1081
            ||              |.||..||.|.:.|.|..:          |.:.|         .::|::
Zfish   417 LQRELEMYNPPKDAEKIPQKDARFSLVQKELEKPVPPPRSEEKYGFQKEGTIERPLTKINSIKLQ 481

  Fly  1082 P-----LATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGS 1141
            |     :|.....|:.:.|.|.                                         ||
Zfish   482 PAQAAAIAAAVSSSRMMQKQVN-----------------------------------------GS 505

  Fly  1142 NAKTCDWVNPAQYGLVQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPT 1206
            ..:..| .:|.....|: ||....|.|..:.|..|||.|
Zfish   506 GERAGD-RSPGDLSTVR-TSVPPPTQPAPEPERSLSRTS-------------------------- 542

  Fly  1207 AYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVE-------------------PGS 1252
                      ....|..|:       .|..|.:...|.:|:..                   |..
Zfish   543 ----------SMQQLEQWV-------RTHRTRAPDDDTRSITSYQTLPRNMPSHRAQIVPRYPEG 590

  Fly  1253 TATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTR 1317
            ..|.|.|....||:                    .|::| .:|.|.:             :..|:
Zfish   591 YRTLPRNMLRPDSI--------------------CSVAG-SVYDRAL-------------QPSTQ 621

  Fly  1318 RERRQIRA----QLKHMTTGARVIRGVDWRWEEQDGCAE---GTI-----TGEIHNGWIDVKWDH 1370
            .:||.||.    ||              :.|:::...:.   ||:     .|:|... |.....|
Zfish   622 EKRRSIRDDTMWQL--------------YEWQQRQAHSRLGYGTLPSPKTMGQIAES-IPTSPSH 671

  Fly  1371 GVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMG--SASTAAKPSEKGGNTLTSRKSSSTPSLPE 1433
            |....|.                  .|..|:.:.  |.|..:.|..:|..|:..|..........
Zfish   672 GSLAGYH------------------TFSPNRPLNPDSRSELSSPVFRGDVTIERRHRPHLSKYSY 718

  Fly  1434 ATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESG 1498
            ..|:...|..   |.::|.:|..| |.|.:...:....:.|...|.|..:|.:
Zfish   719 PAERRAAPPA---QNITAQSLQGK-TPEELTLLLIKLRRQQAELNSLREHTLA------------ 767

  Fly  1499 TNQMHKDNISGPSPLSRELEH--ISDLSAINNSMPAINSSNVSDLATISEN------LSLTELSK 1555
              |:.:.|:...:|.|..|.|  ..:|..:::.|.. |...:..:.|:.||      |...::|.
Zfish   768 --QLMQLNLDATNPKSEILSHHLQRNLMYLDSQMKE-NEPIIFMIHTMIENSAPRPQLYQQQMSP 829

  Fly  1556 ENICRVLTPSYKPAE-------------------------------------SVTASQ----SSS 1579
            |.. |..|..|:|.|                                     .::|||    ||.
Zfish   830 EEY-RENTYMYRPEELDVDAKLSRLCEQDKVVRTQEEKLQQLHREKHTLETALLSASQEIEMSSE 893

  Fly  1580 HPDVQSSSPRENDI---------KNISNI--------EENNKMNANNSVNKISKDLLANLRTSNI 1627
            :|....|..::.|:         :.:|.:        .|.:::.|:.::.|  .:||..|.....
Zfish   894 NPAAVQSVVQQRDVLQSGLLSTCRELSRVSTELERSWREYDRLEADVTLAK--TNLLEQLEALGS 956

  Fly  1628 AGCPPVTQLSTEALEMIDKMRD-------------------GVDMIRNMSNSILSTDTFPVPCTN 1673
            ....|.:|...:..:.:.:::|                   |.:.:..:..|..|.|:..|| ..
Zfish   957 PQTEPPSQKHVQIQKELWRIQDVMEALSKNKPKRNPEPSFPGANPLSTLHKSEDSVDSSCVP-PR 1020

  Fly  1674 VPV-----GGKKTPKAQALINPDNAN---------------QKQIIVTSEEFPTKSSKKPSVTLK 1718
            .|:     ||.:.|   .|.||...:               |:....|..::....|:....|:.
Zfish  1021 PPLPYSYEGGDRPP---PLPNPGQPHTTRTTPHRPEDRKTAQRNGTHTGPDYRLYKSEPELTTVA 1082

  Fly  1719 PAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIA 1783
            ...:.|.    .|..||....|...|...:...|..::..:.|.:|.:|.:|::..|
Zfish  1083 EVDESNG----EDKSEQTAEKEPPGVTKGIVYPVGVVSPRTKSPMPESSTIASYVTL-------- 1135

  Fly  1784 RRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFH-----------SG 1837
             |:|.:    .|.:....:.......:|.:||:.:|.:..|:.:.......|           .|
Zfish  1136 -RKTKK----PDPRTCQPQDRPRSAVEQMSSGAEVGRTRMSVEEQMERIRRHQQGALRERRREDG 1195

  Fly  1838 LLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCR 1902
            .||.:.|:...|:..:......:|..:...|..        ...:|....|::.....|..|:||
Zfish  1196 SLSRSLSFTKDSTYYTLQARKKSPVISPDEQDE--------RRDMTPVERDTKHTKHPDAEENCR 1252

  Fly  1903 -----APA---------------------LLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMV 1941
                 .||                     ||..:..:..:.:|..|.:.|.:.:......||..|
Zfish  1253 DTKEQLPAHTHLEIKDKASVTRSVSMKESLLKSVSPKPVLKQDESECKLEYDRKLATQNSLQTAV 1317

  Fly  1942 SRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKR-QFSALIPAFDPRPGRTNVNQTSDLEISPLG 2005
            ...:.|..|:|..|.......:::  :|.:.|.. :.|.||.|...|...::.:.:||.:..||.
Zfish  1318 MVRVGTEEDEEDEEEEQKDSVQQQ--EDSYELSNSKHSTLISASCDRKNTSSPSSSSDWKSRPLL 1380

  Fly  2006 AELP-------KPQ 2012
            .:||       :||
Zfish  1381 HQLPNTNTTASRPQ 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	20/143 (14%)
		MIB_HERC2	1333..1389	CDD:310955	9/63 (14%)
		DamX	1576..>1725	CDD:330571	33/208 (16%)
		HECTc	2265..2725	CDD:238033
plekha5	XP_021330752.1	WW	13..42	CDD:306827
		WW	58..87	CDD:306827
		PH_PEPP1_2_3	177..280	CDD:270068	25/110 (23%)
		SMC_N	822..>983	CDD:330553	26/163 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900