DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and trip12

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	2735	Identity:	570/2735 - (20%)
Similarity:	923/2735 - (33%)	Gaps:	971/2735 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 PNTPCIQNCVESLSTLLQHEDPMVSDGALKCFASVADRFTRKWV--DPAPLAEYGLTTELLKRLQ 241
            |:.|.|              .|.|:: ..|..|||:.:..::.:  :|||      ...|.|:..
Zfish   147 PSAPAI--------------SPEVTE-PRKAPASVSTKSKKRRLAAEPAP------ARALSKKSS 190

  Fly   242 SVGGNTHSSLT-------AAGTQPTSSSQPAATTNSDAINENVAG-------TATISNSTKVKSS 292
            |..|.:.:|.|       |..|..:|||..:..::|.|     ||       .:..:..||:.|.
Zfish   191 SYPGPSGASSTPSQKRKKADATLLSSSSSSSLPSSSSA-----AGPLPPRSEASRAAKPTKLASK 250

  Fly   293 DAAASPQSISTTISLLSTLCRGSPSITHDILRSQLADALERALQGDERCVLDCMRFADLLLLLLF 357
            .||::....||.....|:....|.|          :.:...|..|...|.....|.
Zfish   251 SAASAKAGCSTVTDSSSSSASSSSS----------SSSSSSAATGTNSCAPQGARL--------- 296

  Fly   358 EGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTHRQLIDCIRSKDSEALREAIESGGIDVNCMDDV 422
              :|..::.....::...:|.|||:                |:|.|..:.|
Zfish   297 --KQGKDQSKARRSRSASSPSPRRS----------------SRDKEQSKAA-------------- 329

  Fly   423 GQTLLNWASAFGTLEMVEYLCEKGADVNKGQRSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDG 487
            |.:..:|||.|            .:.||..:...||        |..||.            |..
Zfish   330 GSSKFDWASRF------------NSKVNLPKPKLSL--------PGSAKA------------ETS 362

  Fly   488 KTPLDKARERLDDGHREVAAILQSPGEWMSPDHSLLNKDGKKYTLMEPRGDPEMAPIYLKVLLPI 552
            ..|          |...:.|.|.|           |.|..||.:...|...|.
Zfish   363 SKP----------GPSGLQAKLAS-----------LRKSTKKRSESPPAELPS------------ 394

  Fly   553 FCR-----TFLGSMLGSVRRASLALIKKIVQYAYPTVLQSLSETSFSEDAA-STSGQNGGNLLIE 611
             ||     ...||...:.||.| .|.|:           ..:|....|..| |.:.|:|.|
Zfish   395 -CRRSTRQKTTGSCASTSRRGS-GLGKR-----------GAAEARRQEKMADSDNNQDGAN---- 442

  Fly   612 VIASVLDNEDDGDGHLIVLNIIEEIMCKTQEEFLDHFARLGVFAKVQALMDTDAEELYVQLPGTV 676
              :|....|:...|.....::...:...|..|.....:.:|   ::|||::...      ||..:
Zfish   443 --SSAARTEETPQGASASSSVAGAVGMTTSGESESDDSEMG---RLQALLEARG------LPPHL 496

  Fly   677 EEPAAAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHWREWSICRGRDCLYVWSD-----SVAL 736
            ..|...:.|.    :..|.........|:::|||                |....|     ..|:
Zfish   497 FGPFGPRMSQ----LFHRTIGSGASSKAQQLLQG----------------LQATGDESQQLQAAI 541

  Fly   737 ELSNGSNGWFRFIIDGKLATMYSSGSP--------------ENGNDSSENRGEFLEKLMRARSCV 787
            |:.       :.::.|...|:  .|.|              |:..|...:....|..:|.|
Zfish   542 EMC-------QLLVMGNEETL--GGFPVKSVVPALITLLQMEHNFDIMNHASRALTYMMEA---- 593

  Fly   788 IAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDDLPGFIFESNRGTKHTF 852
                     ||.:||  :||....:..:|...:|..:.....:|.|:       ..|.|.:|...
Zfish   594 ---------LPRSSA--VVVDAIPVFLEKLQVIQFIDVAEQALTALE-------MLSRRHSKAIL 640

  Fly   853 SAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFK-SAQIIPRGAVAILTDIVK 916
            .         |.|.:...                     :|.::|. :||   |.|:||..:..:
Zfish   641 Q---------AGGLADCL---------------------LYLEFFSINAQ---RNALAIAANCCQ 672

  Fly   917 QIELSFEEQHMAPNGNWETTLTDALMKLSQ-LIHEDGVVSAYEMHSSGLVQALVAVLSVNHWETN 980
            .|  :.:|.|.         :.|:|..|:| |.|:|
Zfish   673 SI--TPDEFHF---------VADSLPLLTQRLTHQD----------------------------- 697

  Fly   981 SPRCKRNKMQKQRVSVFKKCI----LEDNVESATNKPRTKSTASILIQKLVS--VLESTEKLPVY 1039
                        :.||...|:    |.||.:...|          |:|::.|  :|.:.::|.|
Zfish   698 ------------KKSVESTCLCFARLVDNFQHEEN----------LLQQVASRDLLTNIQQLLV- 739

  Fly  1040 LYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDL 1104
             ...|.....:.|:..|: |.|..:.|               |...: ||.|..:
Zfish   740 -LTPPVLSSGMFIMVVRM-FSLMCSNC---------------PCLAV-QLMKQNI---------- 776

  Fly  1105 DRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYI-----GSNAKTCDWVNPAQYGLVQVTSSEG 1164
                                       .|.|.|.:     ||..:..|.|..:...|.::||...
Zfish   777 ---------------------------AETLRFLLCGASNGSCQEQIDLVPRSPQELYELTSLIC 814

  Fly  1165 KTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGS 1229
            :.:|      .|.|:.|             ||:|..:
Zfish   815 ELMP------CLPREGI-------------FAVDAML---------------------------- 832

  Fly  1230 KDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRI--------QQNGRNASGQTHY 1286
            |.||..||            .|:...|    ..|..:|:.:.||        .|||.:.
Zfish   833 KKGSAQTT------------EGAIWQW----RDDRGLWHPYNRIDSRIIETAHQNGEDE------ 875

  Fly  1287 LSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWE------ 1345
            :|||   ..|||..:..:..:.:.|.....|..:|:........|.|...:|..|.|.:
Zfish   876 ISLS---TLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANPNTGGHLEVRREDARAQLMKEDP 937

  Fly  1346 EQDGCAEGTITGEIHNGWI----------------------------DVKWDHGVRNSYRMGAEG 1382
            |...|...|:.|.::..:.                            ||..:|.| :|:......
Zfish   938 ELAKCFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLRNHAV-SSHIASMLS 1001

  Fly  1383 KYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQ 1447
            ..|||:.             :||...|....:|               ||:........||..:|
Zfish  1002 SQDLKIV-------------VGSLQMAEILMQK---------------LPDVFSVYFRREGVMHQ 1038

  Fly  1448 TVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSP 1512
               ..|||..:...|.......|....:.:..:...|:::                ..|:: |..
Zfish  1039 ---VKNLAESEVFLTSPPKACTSGTASLCTTTITTATTTA----------------ASNVT-PDL 1083

  Fly  1513 LSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKPAESVTASQS 1577
            .|...:|..|           :|.::|....:|:.|....|.|....|   |.|.|
Zfish  1084 GSPSFQHSMD-----------DSLDLSPQGRLSDVLKRKRLPKRGPRR---PKYSP--------- 1125

  Fly  1578 SSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVT--QLSTEA 1640
                      ||::|       :.:|:..:..:........||:|.        |.|  :|.|:|
Zfish  1126 ----------PRDDD-------KVDNQAKSPTTTQSPKSSFLASLN--------PKTWGKLGTQA 1165

  Fly  1641 LEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGG-KKTPKAQALINPDNANQKQIIVTSEE 1704
                           |.:||        .|.....|.| .:.|...::.|..:..:..|...:.:
Zfish  1166 ---------------NSANS--------EPSRTAGVSGLARVPPKDSVSNNRDKIKAWIKEQASK 1207

  Fly  1705 FPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEV 1769
            |..:.....||     ...|..|:::    |.:......:..||...|..|  ...|.:.|.|:|
Zfish  1208 FVERYFNSESV-----DGSNPALNVL----QRLCTATEQLNLQMDSGVECL--EEISSIVSESDV 1261

  Fly  1770 AT----HTGLLETFAAIARRRTSQGTNIQDNQIMN----------------AEANVNEHGDQNAS 1814
            ::    |:||::.........:.:.|..:|.:|..                ...:..|:|...|
Zfish  1262 SSFEIQHSGLVKQLLLYLTSNSERDTISRDERIKRFLHVFFGCPIPGQEPPGRLDPTENGPLLA- 1325

  Fly  1815 GSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTIN-HTL 1878
               |.|.:             :..||..:.:|.     ..:..||...|.|.|.|:....| |.|
Zfish  1326 ---LVHKM-------------NNCLSQMEQFPV-----KVHDFPSGNGNGSRGSQALKFFNTHQL 1369

  Fly  1879 TMSL------TSTSS------DSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEE 1931
            ...|      |:...      ..:.::|...:|........|.:.:|   |||:|::.::||.:|
Zfish  1370 KCQLQRHPDCTNVKQWKGGPVKIDPLALVQAIERYLVVRGYGRIREE---DEDSDDDGSDDEIDE 1431

  Fly  1932 --------VGNT--LLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDP 1986
                    .|:.  .||..:..:||.:       |..|           :...||||  :.|.:.
Zfish  1432 SLAAQFLNSGSVRHRLQFYIGEHLLPY-------NMTV-----------YQAVRQFS--LQAEEE 1476

  Fly  1987 RPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTI 2051
            |       :::|.|.:|||       ::|
Zfish  1477 R-------ESTDDEANPLG-------RAG------------------------------------ 1491

  Fly  2052 FRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLS 2116
                                 ||..|:|:.|:.|..:  |..|.::        |..|.|.:..:
Zfish  1492 ---------------------IWTKTHTVWYKPVRED--EEGCKDA--------VGGKRGRAQTA 1525

  Fly  2117 P--NSP---------MHIGFNVADNN------LC------SVDD----VLELLTQINGLNQSEI- 2153
            |  .||         .|.|...:..|      :|      :.||    |:.||..::.:::...
Zfish  1526 PTKTSPRNAKKQDELWHEGVCPSVANPLETYLICDPPEGITFDDPSMEVILLLRVLHSISRYWFY 1590

  Fly  2154 ---DSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQ 2215
               ::..||    ::....||:.|:|.|..:|:|||||:.:..:|.|...|.::|||.|||:|||
Zfish  1591 LYDNAACKE----IIPTGEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQ 1651

  Fly  2216 LYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSP---RRDDHEFRIG-RLKHERVKVPRNEDLL 2276
            :.|..|:|...|::             ||:...:|   :.|..:.|:. ||..::..:.|:| ||
Zfish  1652 MLFYVTAFDRDRAM-------------QRLLDTNPEINQSDSQDSRVAPRLDRKKRTINRDE-LL 1702

  Fly  2277 MWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENST 2341
            ..|..||:...:.:::||:::.:|.|||||||.||||||:.|:||:||.:|     .||:...|.
Zfish  1703 KQAESVMQDLGSSRAMLEIQYENEVGTGLGPTQEFYALVSQELQRADLGLW-----RGEEVTLSN 1762

  Fly  2342 QSAEGNSKPVGYYVNRREHGIFPAPLPQNSE---ICENVLKYFWFFGVFVAKVLQDMRLVDIPLS 2403
            ... |:.:...|..:.|  |:|..|..:.::   |.:..:| |.|.|..:||.:.|.||:|:||.
Zfish  1763 PKV-GSQEGTKYMFSSR--GLFAVPFGRTTKPAHIAKIKMK-FRFLGKLMAKAIMDFRLLDLPLG 1823

  Fly  2404 TSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENL 2468
            ..|.:.                                      :||.:|:        :|..:|
Zfish  1824 LPFYKW--------------------------------------MLRHESS--------ISSHDL 1842

  Fly  2469 KEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLP 2533
            ..|||...:.:|.:::::.:|:.||.|.:.:.|...:.:..|.:   ||  .|:|||.|.|| ||
Zfish  1843 VNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQQALESLNM---NG--CSVEDLGLDFT-LP 1901

  Fly  2534 SSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAF 2598
                 |:...||...|..|.|||.|||.|..|::.:.|.:|:.:|.::|.:||..||||..|..|
Zfish  1902 -----GFPNIELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESFREGFESVFPLHHLQYF 1961

  Fly  2599 TPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCS 2663
            .|.|...::||.:...|..:.::....|..||..||...:....||.|...::::.||||.||..
Zfish  1962 YPEELDQLLCGSKSESWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQRLFLQFVTGSP 2026

  Fly  2664 SLPPGGLANLHPRLTVVRKVDAGVGS----YPSVNTCVHYLKLPDYPTEEIMKERLLTATKE--K 2722
            .||.||..:|:|.||:|||......:    .|||.|||:|||||||.:.|||:|:||.|.:|  :
Zfish  2027 RLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQ 2091

  Fly  2723 GFHLN 2727
            .|||:
Zfish  2092 SFHLS 2096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	4/26 (15%)
		ANK	396..509	CDD:238125	20/112 (18%)
		ANK repeat	422..453	CDD:293786	7/30 (23%)
		ANK repeat	455..484	CDD:293786	5/28 (18%)
		F5_F8_type_C	1173..1298	CDD:329041	24/132 (18%)
		MIB_HERC2	1333..1389	CDD:310955	16/89 (18%)
		DamX	1576..>1725	CDD:330571	24/151 (16%)
		HECTc	2265..2725	CDD:238033	154/468 (33%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915	17/77 (22%)
		HECTc	1693..2094	CDD:238033	154/467 (33%)
		HECTc	1711..2090	CDD:214523	147/444 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3704
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850