DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and trip12

DIOPT Version :10

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_005159283.2 Gene:trip12 / 564866 ZFINID:ZDB-GENE-041111-262 Length:2096 Species:Danio rerio


Alignment Length:2740 Identity:567/2740 - (20%)
Similarity:917/2740 - (33%) Gaps:981/2740 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 PNTPCIQNCVESLSTLLQHEDPMVSDGALKCFASVADRFTRKWV--DPAPLAEYGLTTELLKRLQ 241
            |:.|.|              .|.|:: ..|..|||:.:..::.:  :|||      ...|.|:..
Zfish   147 PSAPAI--------------SPEVTE-PRKAPASVSTKSKKRRLAAEPAP------ARALSKKSS 190

  Fly   242 SVGGNTHSSLT-------AAGTQPTSSSQPAATTNSDAINENVAG-------TATISNSTKVKSS 292
            |..|.:.:|.|       |..|..:|||..:..::|.|     ||       .:..:..||:.|.
Zfish   191 SYPGPSGASSTPSQKRKKADATLLSSSSSSSLPSSSSA-----AGPLPPRSEASRAAKPTKLASK 250

  Fly   293 DAAASPQSISTTISLLSTLCRGSPSITHDILRSQLADALERALQGDERCVLDCMRFADLLLLLLF 357
            .||::....||.....|:....|.|          :.:...|..|...|.....|.         
Zfish   251 SAASAKAGCSTVTDSSSSSASSSSS----------SSSSSSAATGTNSCAPQGARL--------- 296

  Fly   358 EGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTHRQLIDCIRSKDSEALREAIESGGIDVNCMDDV 422
              :|..::.....::...:|.|||:                |:|.|..:.|              
Zfish   297 --KQGKDQSKARRSRSASSPSPRRS----------------SRDKEQSKAA-------------- 329

  Fly   423 GQTLLNWASAFGTLEMVEYLCEKGADVNKGQRSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDG 487
            |.:..:|||.|            .:.||..:...||        |..||.            |..
Zfish   330 GSSKFDWASRF------------NSKVNLPKPKLSL--------PGSAKA------------ETS 362

  Fly   488 KTPLDKARERLDDGHREVAAILQSPGEWMSPDHSLLNKDGKKYTLMEPRGDPEMAPIYLKVLLPI 552
            ..|          |...:.|.|.|           |.|..||.:...|...|.            
Zfish   363 SKP----------GPSGLQAKLAS-----------LRKSTKKRSESPPAELPS------------ 394

  Fly   553 FCR-----TFLGSMLGSVRRASLALIKKIVQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEV 612
             ||     ...||...:.||.| .|.|:           ..:|....|..|.:            
Zfish   395 -CRRSTRQKTTGSCASTSRRGS-GLGKR-----------GAAEARRQEKMADS------------ 434

  Fly   613 IASVLDNEDDGDGHLIVLNIIEEIMCKTQEEFLDHFARLGVFAKVQALMDTDAEELYVQLPGTVE 677
                 ||..||                                     .::.|..       |.|
Zfish   435 -----DNNQDG-------------------------------------ANSSAAR-------TEE 450

  Fly   678 EPAAAQRSSTSVVVAPRPTSDDPMEDAKEI--------LQGKPYHWREWSICRGRDCLY-----V 729
            .|..|..||:........||.:...|..|:        .:|.|.|            |:     .
Zfish   451 TPQGASASSSVAGAVGMTTSGESESDDSEVGRLQALLEARGLPPH------------LFGPFGPR 503

  Fly   730 WSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSENRG--EFLEKLMRARSCVIAGVV 792
            .|......:.:|::...:.::.|..||         |::|.:.:.  |..:.|:......:.|..
Zfish   504 MSQLFHRTIGSGASSKAQQLLQGLQAT---------GDESQQLQAAIEMCQLLVMGNEETLGGFP 559

  Fly   793 SQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSA--- 854
            .:.::|....|          .|..:...|.|.....:|.:.:.||       |.:.....|   
Zfish   560 VKSVVPALITL----------LQMEHNFDIMNHASRALTYMMEALP-------RSSAVVVDAIPV 607

  Fly   855 -----ETVLGPDFASGWSTAKK--KRNKSKTEGQKFQVRNLSREIYNKYFK-SAQIIPRGAVAIL 911
                 :.:...|.|....||.:  .|..||...|...:.:..  :|.::|. :||   |.|:||.
Zfish   608 FLEKLQVIQFIDVAEQALTALEMLSRRHSKAILQAGGLADCL--LYLEFFSINAQ---RNALAIA 667

  Fly   912 TDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQ-LIHEDGVVSAYEMHSSGLVQALVAVLSVN 975
            .:..:.|  :.:|.|.         :.|:|..|:| |.|:|                        
Zfish   668 ANCCQSI--TPDEFHF---------VADSLPLLTQRLTHQD------------------------ 697

  Fly   976 HWETNSPRCKRNKMQKQRVSVFKKCI----LEDNVESATNKPRTKSTASILIQKLVS--VLESTE 1034
                             :.||...|:    |.||.:...|          |:|::.|  :|.:.:
Zfish   698 -----------------KKSVESTCLCFARLVDNFQHEEN----------LLQQVASRDLLTNIQ 735

  Fly  1035 KLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVAK 1099
            :|.|  ...|.....:.|:..|: |.|..:.|               |...: ||.|..:     
Zfish   736 QLLV--LTPPVLSSGMFIMVVRM-FSLMCSNC---------------PCLAV-QLMKQNI----- 776

  Fly  1100 QWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYI-----GSNAKTCDWVNPAQYGLVQV 1159
                                            .|.|.|.:     ||..:..|.|..:...|.::
Zfish   777 --------------------------------AETLRFLLCGASNGSCQEQIDLVPRSPQELYEL 809

  Fly  1160 TSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNW 1224
            ||...:.:|      .|.|:.|             ||:|..:                       
Zfish   810 TSLICELMP------CLPREGI-------------FAVDAML----------------------- 832

  Fly  1225 LLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRI--------QQNGRNAS 1281
                 |.||..||            .|:...|    ..|..:|:.:.||        .|||.:. 
Zfish   833 -----KKGSAQTT------------EGAIWQW----RDDRGLWHPYNRIDSRIIETAHQNGEDE- 875

  Fly  1282 GQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWE- 1345
                 :|||   ..|||..:..:..:.:.|.....|..:|:........|.|...:|..|.|.: 
Zfish   876 -----ISLS---TLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANPNTGGHLEVRREDARAQL 932

  Fly  1346 -----EQDGCAEGTITGEIHNGWI----------------------------DVKWDHGVRNSYR 1377
                 |...|...|:.|.::..:.                            ||..:|.| :|:.
Zfish   933 MKEDPELAKCFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLRNHAV-SSHI 996

  Fly  1378 MGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPE 1442
            .......|||:.             :||...|....:|               ||:........|
Zfish   997 ASMLSSQDLKIV-------------VGSLQMAEILMQK---------------LPDVFSVYFRRE 1033

  Fly  1443 GASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNI 1507
            |..:|   ..|||..:...|.......|....:.:..:...|:::                ..|:
Zfish  1034 GVMHQ---VKNLAESEVFLTSPPKACTSGTASLCTTTITTATTTA----------------ASNV 1079

  Fly  1508 SGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKPAESV 1572
            : |...|...:|..|           :|.::|....:|:.|....|.|....|   |.|.|    
Zfish  1080 T-PDLGSPSFQHSMD-----------DSLDLSPQGRLSDVLKRKRLPKRGPRR---PKYSP---- 1125

  Fly  1573 TASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVT--Q 1635
                           ||::|       :.:|:..:..:........||:|.        |.|  :
Zfish  1126 ---------------PRDDD-------KVDNQAKSPTTTQSPKSSFLASLN--------PKTWGK 1160

  Fly  1636 LSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGG-KKTPKAQALINPDNANQKQII 1699
            |.|:|               |.:||        .|.....|.| .:.|...::.|..:..:..|.
Zfish  1161 LGTQA---------------NSANS--------EPSRTAGVSGLARVPPKDSVSNNRDKIKAWIK 1202

  Fly  1700 VTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVP 1764
            ..:.:|..:.....||     ...|..|:::    |.:......:..||...|..|  ...|.:.
Zfish  1203 EQASKFVERYFNSESV-----DGSNPALNVL----QRLCTATEQLNLQMDSGVECL--EEISSIV 1256

  Fly  1765 STSEVAT----HTGLLETFAAIARRRTSQGTNIQDNQIMN----------------AEANVNEHG 1809
            |.|:|::    |:||::.........:.:.|..:|.:|..                ...:..|:|
Zfish  1257 SESDVSSFEIQHSGLVKQLLLYLTSNSERDTISRDERIKRFLHVFFGCPIPGQEPPGRLDPTENG 1321

  Fly  1810 DQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTI 1874
            ...|    |.|.:             :..||..:.:|.     ..:..||...|.|.|.|:....
Zfish  1322 PLLA----LVHKM-------------NNCLSQMEQFPV-----KVHDFPSGNGNGSRGSQALKFF 1364

  Fly  1875 N-HTLTMSL------TSTSS------DSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENE 1926
            | |.|...|      |:...      ..:.::|...:|........|.:.:|   |||:|::.::
Zfish  1365 NTHQLKCQLQRHPDCTNVKQWKGGPVKIDPLALVQAIERYLVVRGYGRIREE---DEDSDDDGSD 1426

  Fly  1927 DEYEE--------VGNT--LLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALI 1981
            ||.:|        .|:.  .||..:..:||.:       |..|           :...||||  :
Zfish  1427 DEIDESLAAQFLNSGSVRHRLQFYIGEHLLPY-------NMTV-----------YQAVRQFS--L 1471

  Fly  1982 PAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSN 2046
            .|.:.|       :::|.|.:|||       ::|                               
Zfish  1472 QAEEER-------ESTDDEANPLG-------RAG------------------------------- 1491

  Fly  2047 TDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSG 2111
                                      ||..|:|:.|:.|..:  |..|.::        |..|.|
Zfish  1492 --------------------------IWTKTHTVWYKPVRED--EEGCKDA--------VGGKRG 1520

  Fly  2112 ASTLSP--NSP---------MHIGFNVADNN------LC------SVDD----VLELLTQINGLN 2149
            .:..:|  .||         .|.|...:..|      :|      :.||    |:.||..::.::
Zfish  1521 RAQTAPTKTSPRNAKKQDELWHEGVCPSVANPLETYLICDPPEGITFDDPSMEVILLLRVLHSIS 1585

  Fly  2150 QSEI----DSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFP 2210
            :...    ::..||    ::....||:.|:|.|..:|:|||||:.:..:|.|...|.::|||.||
Zfish  1586 RYWFYLYDNAACKE----IIPTGEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFP 1646

  Fly  2211 FETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSP---RRDDHEFRIG-RLKHERVKVPR 2271
            |:|||:.|..|:|...|::             ||:...:|   :.|..:.|:. ||..::..:.|
Zfish  1647 FDTRQMLFYVTAFDRDRAM-------------QRLLDTNPEINQSDSQDSRVAPRLDRKKRTINR 1698

  Fly  2272 NEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGED 2336
            :| ||..|..||:...:.:::||:::.:|.|||||||.||||||:.|:||:||.:|     .||:
Zfish  1699 DE-LLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTQEFYALVSQELQRADLGLW-----RGEE 1757

  Fly  2337 TENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSE---ICENVLKYFWFFGVFVAKVLQDMRLV 2398
            ...|.... |:.:...|..:.|  |:|..|..:.::   |.:..:| |.|.|..:||.:.|.||:
Zfish  1758 VTLSNPKV-GSQEGTKYMFSSR--GLFAVPFGRTTKPAHIAKIKMK-FRFLGKLMAKAIMDFRLL 1818

  Fly  2399 DIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGIL 2463
            |:||...|.:.                                      :||.:|:        :
Zfish  1819 DLPLGLPFYKW--------------------------------------MLRHESS--------I 1837

  Fly  2464 SLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALT 2528
            |..:|..|||...:.:|.:::::.:|:.||.|.:.:.|...:.:..|.:   ||  .|:|||.|.
Zfish  1838 SSHDLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQQALESLNM---NG--CSVEDLGLD 1897

  Fly  2529 FTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLK 2593
            || ||     |:...||...|..|.|||.|||.|..|::.:.|.:|:.:|.::|.:||..||||.
Zfish  1898 FT-LP-----GFPNIELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESFREGFESVFPLH 1956

  Fly  2594 KLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQF 2658
            .|..|.|.|...::||.:...|..:.::....|..||..||...:....||.|...::::.||||
Zfish  1957 HLQYFYPEELDQLLCGSKSESWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQRLFLQF 2021

  Fly  2659 TTGCSSLPPGGLANLHPRLTVVRKVDAGVGS----YPSVNTCVHYLKLPDYPTEEIMKERLLTAT 2719
            .||...||.||..:|:|.||:|||......:    .|||.|||:|||||||.:.|||:|:||.|.
Zfish  2022 VTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAA 2086

  Fly  2720 KE--KGFHLN 2727
            :|  :.|||:
Zfish  2087 REGQQSFHLS 2096

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANKYR <375..>509 CDD:440430 24/133 (18%)
ANK repeat 393..420 CDD:293786 4/26 (15%)
ANK repeat 422..453 CDD:293786 7/30 (23%)
ANK repeat 455..484 CDD:293786 5/28 (18%)
Sad1_UNC 1173..1298 CDD:474037 24/132 (18%)
MIB_HERC2 1333..1390 CDD:461991 16/90 (18%)
HECTc 2265..2725 CDD:238033 154/468 (33%)
trip12XP_005159283.2 None

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