DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and hecw1b

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_021336549.1 Gene:hecw1b / 563730 ZFINID:ZDB-GENE-060503-2 Length:1555 Species:Danio rerio


Alignment Length:1869 Identity:355/1869 - (18%)
Similarity:594/1869 - (31%) Gaps:614/1869 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1064 AECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSF 1128
            :.|.|||      |:..... ||||.....|....|:  ::|...:..:..|.|     |.:.:|
Zfish    83 SHCRSTL------TVSTSSY-TIGQTQDITLSWDIKE--EVDAGDWIGMYLIDE-----VLSENF 133

  Fly  1129 -DFDEEGLLFYIGSNAKTCDWVNPAQYGLVQ------------VTSSEGKTLPYGKLEDILSRDS 1180
             |:...|:   .||:.....|...|....|:            |:.:...|.|            
Zfish   134 LDYKNRGV---NGSHKGQIIWKIEASSYFVEPETKICFKYYHGVSGALRATTP------------ 183

  Fly  1181 ISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDD- 1244
                |.|..|..|.....:....:|.:...|....:   :|.::...|.|.|     :..:.|. 
Zfish   184 ----CVTVKNPSAPVFKPVATDDVPQSQGRRRLISF---SLSDFQATGLKKG-----MFFNPDPY 236

  Fly  1245 -KSLVEPGSTATWP------------INCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYG 1296
             |..:.||..:.:|            |.|.|.:.||.|.            :.:::||.      
Zfish   237 LKIAIHPGKHSIFPALPHHGQEKRSGIVCNTINPVWQRE------------RFNFVSLP------ 283

  Fly  1297 RVVGVADDIGKSVKEAEAKTR-----------------RERRQIRAQLKHMTTGARV----IRG- 1339
                 .|.:...||:..||:|                 .|:..|..::...|.|.|:    :.| 
Zfish   284 -----TDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLEKHAIGDRVVSYTLGRRLPTEHVSGQ 343

  Fly  1340 VDWRWEEQDGCAEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMG 1404
            :.:|:|         ||..||                            .|.|.:| ....|.:.
Zfish   344 LQFRFE---------ITSSIH----------------------------PDDEDMS-LSTEQPVA 370

  Fly  1405 SASTAAKPSEKGGNTLTSRKSSSTPSLP-----EATEKNQNPEGASNQTVSADNL---------- 1454
            :|...|:|..:.    |.......|.||     .:.|...:.|...:....||.:          
Zfish   371 AAEAQAQPQAED----TMSLDLGAPELPLDGDTASVEMPMDVESGQSCAAEADVIEEECLEEEQQ 431

  Fly  1455 ---------AWKQTVETIAENVFASAKTQII-----------SNQLAMNTSSSREARAKHKESGT 1499
                     |.:|: ||.||..     ||::           .|..|....|| :|||..::   
Zfish   432 EGEAAAAAAAMEQS-ETNAEET-----TQVLDPINGAEEEEAENNCAFAEESS-DARAGEED--- 486

  Fly  1500 NQMHKDNISGPSPLSRE----LEHISDL--SAINNSMPAINSSNVSDLAT-ISENLSLTELSKEN 1557
                 :.||.|.|.|.|    ||....|  .......|...|..||:|.| |:......|..:.:
Zfish   487 -----EAISDPQPASEEPDADLEEDCSLRIRTTPRRKPRPCSLPVSELETVIASACGEPETPRSH 546

  Fly  1558 ICRV--LTPSYKPAESVTASQSSSHPDVQSSSPRENDIKNISNIE-ENNKMNANNSVNKISKDLL 1619
            ..|:  |..|....:..|...:...||.......|::.:....:. |::.:..|.....:.:. .
Zfish   547 YIRIHHLLHSLPATQPQTGDSAGPEPDRPMGVEEEDEEEEEEGVTLEDHALTPNGPRRTLPRS-R 610

  Fly  1620 ANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDM-IRNMSNSILSTDTFPVPCTNVPVGGKKTPK 1683
            ::.|.|::             ::|:|  .||..: ....:.:..|.|..||.|.:     ..:|:
Zfish   611 SHERLSDL-------------IQMLD--GDGHPLGAEGQTGNQRSPDLSPVACCS-----HMSPR 655

  Fly  1684 AQALINP---DNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVP 1745
            |...|..   |:|.:.:..|.|.:.....          .:|||.:|......||..........
Zfish   656 ASGPIRAQSLDSARRSESTVFSSQDDEDE----------MEQPNGILGSETETEQGAQCREPGDG 710

  Fly  1746 SQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQ----------GTNIQDNQIMN 1800
            |......|:....|...:....|||..:|..|..........||          ...|.:....|
Zfish   711 SCQWEEAPDSHVQSPHGIVGNGEVAGPSGRRECPLPCNHPAVSQLPALRPDPHHYPTIDEPLPPN 775

  Fly  1801 AEANVNEHGDQNASGSFLGH-SVTSLVKLALSSNFHSGL---------------LSTAQSYPSLS 1849
            .||.::.||    ...::.| :.|:..:...|:....||               ..|.|...:..
Zfish   776 WEARIDSHG----RVFYVDHINRTTTWQRPTSAATPDGLRRSGSVQQMEQLNRRYQTIQRTMATE 836

  Fly  1850 SNNSENIAPSNPSNTSAGQQSASTIN-----------HTLTMSLTSTSSDSEQVSLEDFL----- 1898
            ....|:.:|.|....:....|....|           |...::|...|...:.::..:|.     
Zfish   837 RREEESGSPRNDRTANTETDSPLQTNELRRDTSCSPGHCQKITLLLQSPAVKFITHPEFFTVLHA 901

  Fly  1899 ----------ESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEA 1953
                      .||....:|          :...:..|.:.|:.          :|:|:||:    
Zfish   902 NYGAYRMFTNSSCLKHMVL----------KIRRDARNFERYQH----------NRDLVTFL---- 942

  Fly  1954 MENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPE 2018
                                                    |:.:|.::     |||         
Zfish   943 ----------------------------------------NRFADAQL-----ELP--------- 953

  Fly  2019 TIEQPLLGLKLRGPGIGGIPEVE---IDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTI 2080
                       ||..|...|:.:   :| .|:..|.|...:..||..:|           |.: :
Zfish   954 -----------RGWEIKTDPQGKSFFVD-HNSRATTFIDPRIPLQNGRL-----------PNH-L 994

  Fly  2081 VYREVSPEAQESTCLESEEFPQTPDVS--SKSGASTL------SPNSPMHIGFNVADNNLCSVDD 2137
            .:|:.....:..:..|:.|..:|..||  ::.|.|.:      |...|:.:.:|         |.
Zfish   995 THRQHLQRLRSYSAGEASEVSRTRGVSLLARPGNSLVAAIRNQSQQEPVPLAYN---------DK 1050

  Fly  2138 VLELLTQIN------------GLNQSEIDS--DVKEHGVSVLSE-----DLFISKKITNKLQQQI 2183
            ::..|.|.|            ..|.|..|.  .::..|...|.:     ||.:   :.:..::.|
Zfish  1051 IVAFLRQPNIFEVLQERQPSFARNHSLKDKVHHIRTEGTQRLEKLSCDADLVM---LLSLFEEDI 1112

  Fly  2184 QDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIV---CLQSQRDVTVERQRI 2245
            ...:.||| ..|.:  |.:..|.   |..:.|   |...|.....:|   ||..:.....:|.|.
Zfish  1113 MSYVPLAS-FHPGF--NFSPRCS---PGSSPQ---NSPGFLERTPLVPACCLSGESSPGTQRARA 1168

  Fly  2246 PIMSPRRDDHEFRI----------------GRLKHERVKVPRNEDLLMWAMQVMKTHCNR---KS 2291
            |  :|.|.|.|.::                |::|    .:.|.:.||......:..:..:   ::
Zfish  1169 P--APYRRDFEAKLRNFYRKLEAKGYGQGPGKIK----LIVRRDHLLEGTFNQVMAYSRKELQRN 1227

  Fly  2292 VLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYV 2355
            .|.:.|:.|||... ||:.||:.|::.|:.....       .|.|.:.|.|.:.:  ..|:..:|
Zfish  1228 KLYITFVGEEGLDYSGPSREFFFLLSQELFNPYY-------GLFEYSANDTYTVQ--ISPMSAFV 1283

  Fly  2356 NRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNL 2420
                               ||.|::|.|.|..:...|....|:|...:..|.:.|..        
Zfish  1284 -------------------ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLR-------- 1321

  Fly  2421 QKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNL 2485
                                        |.||            |.:|:.:|...:|.||.|:  
Zfish  1322 ----------------------------LPTD------------LSDLEYLDEEFHQSLQWMK-- 1344

  Fly  2486 LLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNG 2549
                   |.|.|                         :.|.||||.  :..::| .|:.||...|
Zfish  1345 -------ENDIT-------------------------DVLDLTFTV--NEEVFGQVTERELKSGG 1375

  Fly  2550 SSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGE---Q 2611
            ::|.||..|.:.|.|.::.:.::.|:.||.:|...||.||...:.::.|...|..::|.|.   .
Zfish  1376 TNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELELVIAGTAEID 1440

  Fly  2612 FPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHP- 2675
            ...|...     ||.:.||:......:.|...:...:.::|...|||.||.||:|..|...|.. 
Zfish  1441 LNDWRNN-----TEYRGGYHDGHIVIRWFWGAVERFNNEQRLRLLQFVTGTSSVPYEGFTALRGS 1500

  Fly  2676 ---RLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE 2721
               |...:.|. ..:.|.|..:||.:.|.||.||:..::.|:||.|.:|
Zfish  1501 NGLRRFCIEKW-GKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEE 1548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 23/138 (17%)
MIB_HERC2 1333..1389 CDD:310955 9/60 (15%)
DamX 1576..>1725 CDD:330571 25/153 (16%)
HECTc 2265..2725 CDD:238033 105/469 (22%)
hecw1bXP_021336549.1 HECW_N 73..192 CDD:318711 29/141 (21%)
C2_NEDL1-like 213..349 CDD:176073 30/166 (18%)
WW 771..803 CDD:197736 7/35 (20%)
WW 952..983 CDD:197736 10/51 (20%)
HECTc 1223..1552 CDD:214523 102/444 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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