DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and herc4

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_005173092.1	Gene:	herc4 / 557513	ZFINID:	ZDB-GENE-070801-1	Length:	1052	Species:	Danio rerio

Alignment Length:	764	Identity:	162/764 - (21%)
Similarity:	284/764 - (37%)	Gaps:	217/764 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1995 QTSDLEISP-LGAELPK---PQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSN----TDWTI 2051
            ||...:||. :.|.|.|   |:.|..|..||...|.|.|        ||..: |.|    |..||
Zfish   473 QTDHPQISQIIAASLEKNLLPKLSSSPPDIEALRLYLTL--------PECPL-LCNPNNFTTLTI 528

  Fly  2052 -FRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQEST--CLESEEFPQTPDVSSKSGAS 2113
             |......|:.:.:..|..:...:||   :|::.:....:|..  .|..::
Zfish   529 PFAKAIVSLKDAPIKVLGNWWSRFEP---VVFQRLVELYKEVVVYLLRMQK-------------- 576

  Fly  2114 TLSPNSPMHIGFNVADNNL--CSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKIT 2176
                     :|..:::..:  |.:|..|:||         ||...|.|....::..|.|...::
Zfish   577 ---------LGIPLSEQRIFTCFLDTSLKLL---------EILHSVNERAGQIIQYDKFYIHEL- 622

  Fly  2177 NKLQQQIQDPLVLASNALPNWCENLNQS---------CPFLFPFETRQLYFNCTSFGASRSIVCL 2232
                    |.|:...|....|.:....|         |.:.|.|:.:          |..:::
Zfish   623 --------DELIDIRNDYATWFQQQMFSVVMDSQVTLCKYPFVFDAQ----------AKTALL-- 667

  Fly  2233 QSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVK-----VPRNEDLLMWAMQVMKTHCN--RK 2290
              |.|..::.|.....:.|::.....:.....|.|.     :.|.|:::..:|:|::...|  .|
Zfish   668 --QTDAVIQMQMAVDQAQRQNFTSLFLSGGGVESVNPCLILIVRRENVVGDSMEVLRKSKNVDYK 730

  Fly  2291 SVLEVEFLDEEGTGLGPT-LEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYY 2354
            ..|:|.|:.||....|.. .||:.|:..|:...
Zfish   731 KPLKVIFVGEEAVDAGGVRKEFFLLIMKELLHP-------------------------------- 763

  Fly  2355 VNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRN 2419
                ::|:|  ...:.|.:       .|    |..|..:|:.|..:      :.::|...:.:..
Zfish   764 ----KYGMF--RFHEESRL-------IW----FACKTFEDIDLFHL------IGVVCGLAIYNLT 805

  Fly  2420 LQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQN 2484
            :.::     |..|::..          |||:...          :||:|||:.|...:.||::.:
Zfish   806 IVEL-----NFPLALYK----------KLLKKTP----------TLEDLKELMPDVGRSLQQLLD 845

  Fly  2485 LLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQ-AELLPN 2548
                                        .|::.||   |...|.||....:  :|.|: .||:||
Zfish   846 ----------------------------YTEDDLE---ETFCLNFTITEDN--FGATEVVELIPN 877

  Fly  2549 GSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFP 2613
            |:.::|...|.:.:....:::|....:|.|..||..||::|...|.|..|.|||.:.|:.|....
Zfish   878 GTDISVNKSNRQEFVNAYVDYIFNKSVAPQFSAFYAGFHKVCGGKVLELFQPSELQAMVIGNTNY 942

  Fly  2614 HWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLT 2678
            .|  :::...||.|..|..|.|..:.|..|...:..:::|.||.|.||...:|..|:.:|   ..
Zfish   943 DW--KELEKSTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL---AL 1002

  Fly  2679 VVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATK-EKGFHL 2726
            |::....|...:|..:||.:.|.||.|.::..|:|:||.|.: .:||:|
Zfish  1003 VIQPTAGGEQYFPVAHTCFNLLDLPKYTSKNTMQEKLLHAIEHNQGFNL 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	105/469 (22%)
herc4	XP_005173092.1	RCC1	3..49	CDD:278826
		RCC1	52..99	CDD:278826
		RCC1	102..152	CDD:278826
		RCC1	156..205	CDD:278826
		RCC1	208..257	CDD:278826
		RCC1	260..308	CDD:278826
		RCC1	313..377	CDD:278826
		HECTc	704..1049	CDD:238033	102/462 (22%)
		HECTc	730..1049	CDD:214523	97/436 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900