DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and HERC6

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_005263140.1 Gene:HERC6 / 55008 HGNCID:26072 Length:1034 Species:Homo sapiens


Alignment Length:1184 Identity:228/1184 - (19%)
Similarity:366/1184 - (30%) Gaps:495/1184 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  1703 EEFPTKSSKKPSVTLK--PAQQPNA------VLSIVDIK---------EQPISNENVSVPSQMSI 1750
            :|||:::|.:...:|:  |..|..|      .||:....         :..:|..||.|.|...:
Human   176 KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPL 240

  Fly  1751 SV---PNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQN 1812
            ||   .||.....|...:.:.|.|..|.:.||                             || |
Human   241 SVGALKNLGVVYISCGDAHTAVLTQDGKVFTF-----------------------------GD-N 275

  Fly  1813 ASGSFLGHSVT-------------SLVKLALSSNFHS-GLLSTAQSYPSLSSNNSENIAPSNPSN 1863
            .||. ||:|.|             .||......::|: ..:.|.....|.....|:...|::|. 
Human   276 RSGQ-LGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPE- 338

  Fly  1864 TSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLE----------------------SCRAPAL 1906
                             :||.....|..:|.|||::                      |.|||  
Human   339 -----------------ALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAP-- 384

  Fly  1907 LGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEF 1971
                                      |.||.:  :||      ..::|..:.:.| ||:|.:.|.
Human   385 --------------------------GKTLPE--ISR------ISQSMAEKWIAV-KRRSTEHEM 414

  Fly  1972 V---LKRQFSA---LIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLR 2030
            .   ::..||:   |..:|                                          ||.|
Human   415 AKSEIRMIFSSPACLTASF------------------------------------------LKKR 437

  Fly  2031 GPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCL 2095
            |.|.....:|:::::.                     |.|:|:.:..:.        .:..:|||
Human   438 GTGETTSIDVDLEMAR---------------------DTFKKLTKKEWI--------SSMITTCL 473

  Fly  2096 ESEEFPQTPDVSSKSGAST---LSPNSP-MHIGFN-----------------------------V 2127
            |.:.....|..|....|.:   |.|..| ||...|                             :
Human   474 EDDLLRALPCHSPHQEALSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFL 538

  Fly  2128 ADNNLCSVDDVLE--LLTQINGLNQSEIDSD----------VKE-HGVSV----LSEDLFISKKI 2175
            .:::|..:..:|:  :::|:  |:|::.:.|          :|| |.|:.    |.|:.|...::
Human   539 QESSLNPLIQMLKAAIISQL--LHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINEL 601

  Fly  2176 TNKL-------QQQIQD-PLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCL 2232
            :|.|       :|..:| .|:.|....|....:        |||     .||..|     .|..|
Human   602 SNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSD--------FPF-----IFNSLS-----KIKLL 648

  Fly  2233 QSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNE------------------DLLMWA 2279
            |:...:.::      ||      |.:...|.||.:...::|                  |.|...
Human   649 QADSHIKMQ------MS------EKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQL 701

  Fly  2280 MQVMKT-HCNRKSVLEVEFLDE---EGTGLGPTLEFYALVAAEIQRSDL----------CMWLCD 2330
            .|...| .|   .||.|||::|   |..|:  :.||:..:..|:.:.:.          |||   
Human   702 SQAEATDFC---KVLVVEFINEICPESGGV--SSEFFHCMFEEMTKPEYGMFMYPEMGSCMW--- 758

  Fly  2331 DDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPA-PLPQNSEICENVLKYFWFFGVFVAKVLQD 2394
                                            ||| |.|:.        |.::.||:.....|.:
Human   759 --------------------------------FPAKPKPEK--------KRYFLFGMLCGLSLFN 783

  Fly  2395 MRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAF 2459
            :.:.::|...:              |.|.:.|::.                              
Human   784 LNVANLPFPLA--------------LYKKLLDQKP------------------------------ 804

  Fly  2460 GGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLED 2524
                |||:|||:.|...:.|||:                                   |:.:.:|
Human   805 ----SLEDLKELSPRLGKSLQEV-----------------------------------LDDAADD 830

  Fly  2525 L--ALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFN 2587
            :  ||...:   |..:.....:|:|||.|:.|...|...|....:::|....:....:.|..||.
Human   831 IGDALCIRF---SIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFY 892

  Fly  2588 EVFPLKKLAAFTPSEARMMICGEQFPHWSR-EDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDE 2651
            .|...:.|..|.|.|....|.|.....|.: |....|.:   ||.|..|..|.|......::.||
Human   893 RVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQ---GYQKSHPTIQLFWKAFHKLTLDE 954

  Fly  2652 RKAFLQFTTGCSSLPPGGLANLH-----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIM 2711
            :|.||.|.||...|...|:..:.     |.....|       .:|:..||.:.|.||.|.|.|.|
Human   955 KKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSER-------DHPTSITCHNILSLPKYSTMERM 1012

  Fly  2712 KERLLTA-TKEKGF 2724
            :|.|..| ...:||
Human  1013 EEALQVAINNNRGF 1026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041
MIB_HERC2 1333..1389 CDD:310955
DamX 1576..>1725 CDD:330571 7/23 (30%)
HECTc 2265..2725 CDD:238033 104/502 (21%)
HERC6XP_005263140.1 RCC1_2 27..54 CDD:290274
RCC1_2 89..118 CDD:290274
RCC1 105..155 CDD:278826
RCC1 158..208 CDD:278826 8/31 (26%)
RCC1 215..263 CDD:278826 10/47 (21%)
RCC1_2 250..279 CDD:290274 10/58 (17%)
RCC1 266..313 CDD:278826 15/77 (19%)
HECTc 684..1026 CDD:238033 100/485 (21%)
HECTc 711..1026 CDD:214523 95/455 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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