DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and PLEKHA5

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_001243399.1 Gene:PLEKHA5 / 54477 HGNCID:30036 Length:1282 Species:Homo sapiens


Alignment Length:1696 Identity:287/1696 - (16%)
Similarity:491/1696 - (28%) Gaps:686/1696 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  1100 QWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTCDWVNPAQYGLVQVTS--S 1162
            :|..|.||                  .::.....|.:|:|...||:..|::|.. |...||.  .
Human     8 EWISLPRS------------------WTYGITRGGRVFFINEEAKSTTWLHPVT-GEAVVTGHRR 53

  Fly  1163 EGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLL- 1226
            :...||.|                       |          ..|||...||.|.....|.... 
Human    54 QSTDLPTG-----------------------W----------EEAYTFEGARYYINHNERKVTCK 85

  Fly  1227 -----QGSKDGSTWT----TLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASG 1282
                 |.|:|...:.    |::|...::....|.|.    ||.|::.:|            .:..
Human    86 HPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISM----INEASNYNV------------TSDY 134

  Fly  1283 QTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQL-------KHMTTGARVIRGV 1340
            ..|.:|         .||......|.|.....::...:|...|.:       |..:||.::    
Human   135 AVHPMS---------PVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKL---- 186

  Fly  1341 DW--RW-------------EEQDGCAEGTI----------TGEIH-NGWIDVKWDHGVRNSYRMG 1379
             |  ||             |:::|.. |:|          |.|.| |.....|..|....:|...
Human   187 -WKKRWFVLSDLCLFYYRDEKEEGIL-GSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFC 249

  Fly  1380 AEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGA 1444
            .:...:::|    ::.|.     :.:|....:|.::  .|...|....|.......|.|..|   
Human   250 TDTGKEMEL----WMKAM-----LDAALVQTEPVKR--ITFNFRVDKITSENAPTKETNNIP--- 300

  Fly  1445 SNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISG 1509
                                 |.....|.:|.:||.....|...|.:|...|....|  ||....
Human   301 ---------------------NHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQ--KDGQDR 342

  Fly  1510 PSPLSRELEHISDLSAIN----NSMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKPAE 1570
            |            |:.||    ||:|                   :|....:.|...|..|:|  
Human   343 P------------LTKINSVKLNSLP-------------------SEYESGSACPAQTVHYRP-- 374

  Fly  1571 SVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQ 1635
                                              :|.::|.|||....||:||..|.....|:..
Human   375 ----------------------------------INLSSSENKIVNVSLADLRGGNRPNTGPLYT 405

  Fly  1636 LSTEALEMIDKMRDGVDMIR--------NMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDN 1692
            .:...::..:.|:.....|:        ..:..::|..|.|   .|:|                 
Human   406 EADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLP---RNMP----------------- 450

  Fly  1693 ANQKQIIVTSEE----FPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVP 1753
            :::.||:....|    .|..|..:|                          |::           
Human   451 SHRAQIMARYPEGYRTLPRNSKTRP--------------------------ESI----------- 478

  Fly  1754 NLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNI------QDNQIMNAEANVNEHGDQN 1812
                  .|..|||.:.....|..|      :||:.:...:      |..|..|.::.:..|    
Human   479 ------CSVTPSTHDKTLGPGAEE------KRRSMRDDTMWQLYEWQQRQFYNKQSTLPRH---- 527

  Fly  1813 ASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHT 1877
                                    ..||:.::..::|.....:| |::||:.|.......:...|
Human   528 ------------------------STLSSPKTMVNISDQTMHSI-PTSPSHGSIAAYQGYSPQRT 567

  Fly  1878 LTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVS 1942
            ....::|                   |...||                             |.:.
Human   568 YRSEVSS-------------------PIQRGD-----------------------------VTID 584

  Fly  1943 RNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAE 2007
            |.      ..|...:.|.|..|:|              :||     |.|            |.:.
Human   585 RR------HRAHHPKHVYVPDRRS--------------VPA-----GLT------------LQSV 612

  Fly  2008 LPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSN-TDWTIFRAVQELLQC-SQLNK---- 2066
            .|:..|...||  |..||.:|||        ..:.:||: .:.|:.:.:|..|:. |..|:    
Human   613 SPQSLQGKTPE--ELTLLLIKLR--------RQQAELSSIREHTLAQLMQLKLEAHSPKNEILSH 667

  Fly  2067 --------LDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSK---------SGAST 2114
                    ||...|..||..|:|:..:     |::.|..:.:.|.....||         .|..|
Human   668 HLQRNTIYLDHQMKENEPIITMVHTMI-----ENSALRPQLYQQFLRQKSKISLYCLSQDEGRGT 727

  Fly  2115 LSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKL 2179
            |....|..:..:...:.||..|.|:..|.:  .|.|...:....|..:...|:::.:.......:
Human   728 LYKYRPEEVDIDAKLSRLCEQDKVVHALEE--KLQQLHKEKYTLEQALLSASQEIEMHADNPAAI 790

  Fly  2180 QQQI--QDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVER 2242
            |..:  :|.|   .|.|.:.|..|:::        |.:|......:.        :.:.||||.|
Human   791 QTVVLQRDDL---QNGLLSTCRELSRA--------TAELERAWREYD--------KLEYDVTVTR 836

  Fly  2243 QRIPIMSPRRDDHEFRIGRLKHERVKVPRNE-DLLMW----AMQVMKTHCNRKSVLE-------- 2294
            .::    ..:.||   :|.::.|...:.|.: ...:|    .|:.:..|..::...|        
Human   837 NQM----QEQLDH---LGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKP 894

  Fly  2295 ---VEFLDEE------------------------------------------------------- 2301
               |::.:||                                                       
Human   895 FSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGY 959

  Fly  2302 ---GTGLGPTLEFY-----ALVAAEIQRSDLCMWLCDDDLGED-----TENSTQSAEGNSKPVGY 2353
               |:..||....|     ....||:          |:..||:     :|..|...:|:..|||.
Human   960 PRNGSHCGPDYRLYKSEPELTTVAEV----------DESNGEEKSEPVSEIETSVVKGSHFPVGV 1014

  Fly  2354 YVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLC------- 2411
            ...|.:     :|.|::|.|...|.       :...|.:.|:| .:.|.|.  ::.||       
Human  1015 VPPRAK-----SPTPESSTIASYVT-------LRKTKKMMDLR-TERPRSA--VEQLCLAESTRP 1064

  Fly  2412 ------HNKVLSRNLQKVISDRRNGDLSVVS-------------EDSDIVETCTK---------L 2448
                  ..:.:.|:.|..:.:::.| |:|:.             .|:....|.|:         .
Human  1065 RMTVEEQMERIRRHQQACLREKKKG-LNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTA 1128

  Fly  2449 LRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQ-------NLLLRKQ-----SIEF------- 2494
            :|.:..|.:.......:..|||.:|....|.:|::       .:|...:     |:|.       
Human  1129 IRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNK 1193

  Fly  2495 ------------DDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQA--EL 2545
                        |:|.:|..|.|  ...:..|:|.:: ..|:..:::...|..|....|.|  .|
Human  1194 DKMPEDVTFSPQDETQTANHKPE--EHPEENTKNSVD-EQEETVISYESTPEVSRGNQTMAVKSL 1255

  Fly  2546 LPNGSS 2551
            .|:..|
Human  1256 SPSPES 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 21/134 (16%)
MIB_HERC2 1333..1389 CDD:310955 15/81 (19%)
DamX 1576..>1725 CDD:330571 24/160 (15%)
HECTc 2265..2725 CDD:238033 71/439 (16%)
PLEKHA5NP_001243399.1 WW 12..41 CDD:278809 9/46 (20%)
WW 58..87 CDD:278809 11/61 (18%)
PH_PEPP1_2_3 164..267 CDD:270068 21/117 (18%)
PH 170..266 CDD:278594 19/110 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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