DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Wwc2

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_598552.2	Gene:	Wwc2 / 52357	MGIID:	1261872	Length:	1187	Species:	Mus musculus

Alignment Length:	1408	Identity:	257/1408 - (18%)
Similarity:	461/1408 - (32%)	Gaps:	432/1408 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1131 DEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSE--GKTLPYGKLEDILSR------DSISLNCHT 1187
            |.:|.:|||..|.:...|::|.......::.::  |..||:|.......:      |.|:.....
Mouse    21 DYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGAYYIDHINKTTQI 85

  Fly  1188 KDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGS 1252
            :|.:|.|                   ||.....|::: |..::|.........||.::.|.
Mouse    86 EDPRKQW-------------------RGEQEKMLKDY-LSVAQDALRTQKELYHVKEQRLA---- 126

  Fly  1253 TATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTR 1317
                   .|.|:     ::|:....:..| .:|....||       ...:......:.:||..|.
Mouse   127 -------LALDE-----YVRLNDAYKEKS-SSHTSLFSG-------SSSSTKYDPDILKAEISTT 171

  Fly  1318 RER-RQIRAQLKHM-------TTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDHGVRN 1374
            :.| ::::.:|.||       ..|...::.:|   |:..|...|....|......::|   .:|.
Mouse   172 QLRVKKLKRELSHMKQELLYKQQGFETLQQID---EKMSGGQSGYELNEAKAILTELK---SIRK 230

  Fly  1375 SYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQ 1439
            :...|.:.|.||..:..:....|..:|:|||:....:.|....:...||               |
Mouse   231 AISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRSSPVNSHLSLSR---------------Q 280

  Fly  1440 NPEGASNQTVSAD-------NLAWKQTVETIAENVFAS-AKTQIISNQL-------AMNTSSSRE 1489
            ..:..|..::|.|       |||.|..:....|....| |..:|..::|       |::....:.
Mouse   281 TLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDGEAWPGALDIEKEKL 345

  Fly  1490 ARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSM-PAINSSNVSDLATISENLSLTEL 1553
            .....||    ::.|: :...:|..|..|.:..|.|....: ..:.::..|....::|.|.|.|.
Mouse   346 MLINEKE----ELLKE-LQFITPQKRSQEELERLEAERQHLEEELMAARGSPSRALTERLKLEEK 405

  Fly  1554 SKENICRVLTPSYKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDL 1618
            .||.:.::        |..|...:|.:..:||.|.....:.:.|::  .:..::..|:|..|:..
Mouse   406 RKELLQKL--------EETTKLTTSLYSQLQSLSSSTLSMSSGSSL--GSLASSRGSLNTSSRGS 460

  Fly  1619 LANLRTSNIAGCPPVTQLSTE---ALEMIDKMRDGV------------DMIRNMSNS-------- 1660
            |.:|.:|.:.......|:.|:   .|:.:.:.:.|.            :::::.|..
Mouse   461 LNSLSSSELYYSSQGDQMDTDYQYKLDFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSGLCGV 525

  Fly  1661 --ILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQP 1723
              ..|:.|.|:...:..|....:..:.:.::|..:.    :|....|| .||...|....|....
Mouse   526 GVTASSHTTPLTEASKSVASLSSRSSLSSLSPPGSP----LVLDSVFP-GSSHDTSPHQFPTDFE 585

  Fly  1724 NAVLS--IVDI---------------KEQPI------------------SNENVSVPSQMSISVP 1753
            :..||  ..|:               ..||:                  ::...|:|.:..:.:.
Mouse   586 DCELSRRFADVGLGENQALLDSDSGGASQPLLEDKGLSDCPGELLCEGATDVEKSLPKRRGLHLR 650

  Fly  1754 NLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQ-----IMNAEANVNEHGDQNA 1813
            ...||..|...|...||..:|:.|.    :.::..:..::..::     :..|:..:....|..:
Mouse   651 GDKTTRVSAAASDESVAGDSGVYEA----SMKQPGEMEDVPYSEEDVTIVETAQVQIGLRYDTKS 711

  Fly  1814 SGSF--------------LGHSVTSLVKLAL--SSNFHSGLLSTAQSYP--SLSSNNSENIAPSN 1860
            | ||              :.||.....::||  ||...|.|..|....|  |:..|:...:|.|.
Mouse   712 S-SFMVIIAQLRNLHAFSIPHSSKVYFRVALLPSSADVSCLFRTKVHPPTESVLYNDVFRVAVSQ 775

  Fly  1861 PSNTSAGQQSASTINHTLTMSLTSTSSD-------SEQVSLED-------------FLESCRAPA 1905
                :|.||.      ||.:.|.|.|..       ..|:||.|             .|.|.:.|.
Mouse   776 ----AALQQK------TLRVDLCSASKHRREECLAGTQISLADLPFSNEIFMLWYNLLPSKQMPC 830

  Fly  1906 LLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMV---------------SRNLLTFMDDEAME 1955
                             ::|||..||.|....|.|:               |..||....:.|.|
Mouse   831 -----------------KKNEDGNEEPGARSQQPMLDPIDLDAVSALLARTSAELLAVEQELAQE 878

  Fly  1956 NRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGR---TNVNQTSDLEIS------PLG-----A 2006
            ..          ::|...:|:          .|||   |.:.:.||...:      ||.     .
Mouse   879 EE----------EEELRPERR----------GPGRDCLTMLREASDEPAALRESGVPLAEGSRCT 923

  Fly  2007 ELPKPQQSGGPETIE---QPLLGLKLRGPG--IGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNK 2066
            |.|||... ||||.:   :|     ...||  ..|:|.:....:|||
Mouse   924 EDPKPCPR-GPETSQCRKEP-----AEDPGQLPSGLPTLVDKETNTD------------------ 964

  Fly  2067 LDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNN 2131
                        .:|...::...::.:.|.|.:.|...: |....:.|.||.
Mouse   965 ------------EVVDSNMAVRPKDRSSLSSRQHPFVRN-SVIVRSQTFSPG------------- 1003

  Fly  2132 LCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFI---SKKITNKLQQQIQDPLVLASNA 2193
                    |....|..||:|:.||.      ::..:.||:   :::.:.::::.:..|.:
Mouse  1004 --------ERSQYICRLNRSDSDSS------TLAKKSLFVRNSTERRSLRVKRAVCQPTL----- 1049

  Fly  2194 LPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFR 2258
                 ....|.||.                   |:.:.|:.....::.||     |...|:.:..
Mouse  1050 -----RRTAQECPV-------------------RTSLDLELDLQASLTRQ-----SRLNDELQAL 1085

  Fly  2259 IG-RLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRS 2322
            .| |.|.|.:|.....||             ...|||    ||....|....|..|....|.|:.
Mouse  1086 RGLRQKLEELKAQGETDL-------------PPGVLE----DERFQKLLKQAEKQAEQTKEEQKQ 1133

  Fly  2323 DL----CMWLCDDD---LGEDTENSTQSAEGNSKPVGYYVNRR 2358
            ||    .|.....|   |.|.::...:..:...:.:.|:...:
Mouse  1134 DLNAERLMRQVSKDVCRLREQSQKEPRQVQSFREKIAYFTRAK 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	20/130 (15%)
		MIB_HERC2	1333..1389	CDD:310955	12/55 (22%)
		DamX	1576..>1725	CDD:330571	28/173 (16%)
		HECTc	2265..2725	CDD:238033	21/101 (21%)
Wwc2	NP_598552.2	WW	12..41	CDD:278809	7/19 (37%)
		WW	59..88	CDD:278809	5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..464		5/27 (19%)
		C2_Kibra	699..822	CDD:176062	31/133 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..849		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..963		25/114 (22%)
		Phage_Nu1	<1088..>1146	CDD:294991	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900