DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and UBR5

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_056986.2 Gene:UBR5 / 51366 HGNCID:16806 Length:2799 Species:Homo sapiens


Alignment Length:2966 Identity:506/2966 - (17%)
Similarity:874/2966 - (29%) Gaps:1140/2966 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   558 LGSMLGSVRRASLALIKKIVQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVL---DN 619
            |||....|..||: :.::::..| ..|||..|.:....:...|      ||.:.:..:.|   |:
Human   172 LGSQPQPVIPASV-IPEELISQA-QVVLQGKSRSVIIRELQRT------NLDVNLAVNNLLSRDD 228

  Fly   620 EDDGDGHLIVLNII---EEIMCKTQEEFLD---HFARLGVFAKVQALMDTDAEELYVQLPGTVEE 678
            ||..||........   |::|     ..||   |.|...|.....|:...|..  |...| :...
Human   229 EDGDDGDDTASESYLPGEDLM-----SLLDADIHSAHPSVIIDADAMFSEDIS--YFGYP-SFRR 285

  Fly   679 PAAAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHWREWS------------------------ 719
            .:.::..|:.|::.|.....:.:.:.:.:|:.:...|.:.:                        
Human   286 SSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPV 350

  Fly   720 ---ICRGRDCLYVWSDSVALELSNGSNGWFRFIIDG----KLATMYSSGS--PENGNDSSENRGE 775
               :..|.| |..|.|      .:|:    :||..|    :|..:.|.|.  ....::|...|..
Human   351 QSPVSLGED-LQWWPD------KDGT----KFICIGALYSELLAVSSKGELYQWKWSESEPYRNA 404

  Fly   776 FLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDDLPGF 840
            ....|...|:..:.....:.:|.:|:::|..|.                ||.::|....|:....
Human   405 QNPSLHHPRATFLGLTNEKIVLLSANSIRATVA----------------TENNKVATWVDETLSS 453

  Fly   841 IFESNRGTKHTFS---AETVLGPDFASGWSTA-----------------KKKRNKSKTEGQKFQV 885
            :......|..|:|   .|.::.....:.::.|                 ||...|::.:.:|   
Human   454 VASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKK--- 515

  Fly   886 RNLSREIYNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHE 950
                              |:.:..|.:               .||   .|..|...::.:.|.|.
Human   516 ------------------PKSSAGISS---------------MPN---ITVGTQVCLRNNPLYHA 544

  Fly   951 DGVVSAYEMHSSGLVQALVAVLSVNHWETN--------SPRCKRNKMQKQRVSVFK--------- 998
            ..|  |:.: |:|:.:  |.||..:.|..|        ||...:|..:..:.:..|         
Human   545 GAV--AFSI-SAGIPK--VGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVK 604

  Fly   999 -----------KCILEDNVESATNKP--RTKSTASILIQKLVS----------VLESTEKLPV-- 1038
                       .|....::.|:.:.|  |.:||.:...::.|:          .:|..:.:||  
Human   605 TEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGK 669

  Fly  1039 -------YL--------YDSPCTGYS------LQILQKRLRFRLERAECEST--------LFDRS 1074
                   |:        .::.|...|      ..:||.....|::..:...|        .|.|:
Human   670 VLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRT 734

  Fly  1075 GRTL----KMEPLAT------------IGQLSKY----LLKMVAKQWYDLDRSTYFYLKKIREHR 1119
            .:.|    |.|.||.            .|...:|    |....|:|..:...|:..:|.  :..|
Human   735 PKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLG--QNER 797

  Fly  1120 TATVFTHSFDF-----DEEGLLFYIGSNAKTC-------DWVNPAQYGLVQVTSSEGKTLPYGKL 1172
            ...:||...:.     |..|.::.:   ||.|       ||:                       
Human   798 NVAIFTAGQESPIILRDGNGTIYPM---AKDCMGGIRDPDWL----------------------- 836

  Fly  1173 EDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAY----TLRHARGYGRSALRNWLL---QGSK 1230
             |:....|:.:..|:..|..|...|.....:|..|.    .::|.......|.|.:|:   |...
Human   837 -DLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV 900

  Fly  1231 DGSTWTTLSTHVD-----DKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLS 1290
            .......|.|.:.     :::::....:..:|.:        .:..:.::....:...|....||
Human   901 LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTS--------NKETKEEEEAERSERNTFAERLS 957

  Fly  1291 GFEIYGRVVGVADDIGKSVKEAEAKTR--RERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEG 1353
            ..|.....:.|....|...:...:.:|  |.|..:|..|:....|           ..:.|.:..
Human   958 AVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLG-----------RHEAGASSS 1011

  Fly  1354 TITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGN 1418
            .....:........|   |.:...|..:|..|..||           .::||.:|||..:.:|.:
Human  1012 DHQDPVSPPIAPPSW---VPDPPAMDPDGDIDFILA-----------PAVGSLTTAATGTGQGPS 1062

  Fly  1419 TLTSRKSSSTPSLPEATEKNQN--------------------------PEGASNQTVSADNLAWK 1457
            |.|....|:.||:.|:.::..|                          ..|.:....:....|:.
Human  1063 TSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYP 1127

  Fly  1458 QTVETIAENVFASAKTQIISNQ------------------------LAMNTSSS----------- 1487
            ..: ||.|.....||.:|.|::                        |..|.:.|           
Human  1128 AAI-TILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQ 1191

  Fly  1488 ------------------REARAKHKESGTNQMHKDNISGPSPL-------------------SR 1515
                              ..||..||.      |...:...||.                   |.
Human  1192 DIFECRTCGLLESLCCCTECARVCHKG------HDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSA 1250

  Fly  1516 ELEHISDLSAINNSMPAINSSNVSDLATISENLSL---TELSKENI--CRVLTPSYKPAES-VTA 1574
            .|:.:..|....|.:...||.        .|:|.|   ..::::.:  |:...|..:...: .||
Human  1251 RLDLLYRLLTATNLVTLPNSR--------GEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTA 1307

  Fly  1575 S-QSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSV----NKISKDLLANLRTSNIAGCPPVT 1634
            | :.|..||.....||...:.....:::   .||..|:    ::.:||.|:  .:|.|....|..
Human  1308 SPEDSDMPDHDLEPPRFAQLALERVLQD---WNALKSMIMFGSQENKDPLS--ASSRIGHLLPEE 1367

  Fly  1635 QLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFP----VPCT------------------NVPVG 1677
            |                 :..|..:..:..|.|.    |.||                  |....
Human  1368 Q-----------------VYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTP 1415

  Fly  1678 GKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKP---------AQQPNAVLSIVDIK 1733
            |::.......:....:..:..::.|.|. ..|.||.:...:|         |..|.||..:.::.
Human  1416 GRREEAIAVTMRFLRSVARVFVILSVEM-ASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVA 1479

  Fly  1734 EQPISNENVSVPSQMSISVPNLTTTSASEV-------------------PSTSEVATHTGLLETF 1779
            |..|      ||.:|.|:.|....|.||..                   ||:.:.::.:....::
Human  1480 ESLI------VPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSY 1538

  Fly  1780 AAIAR----RRTSQ-----GTNIQDNQIMNAEA-----------------NVNEHGDQN--ASGS 1816
              |.|    ||.||     |.:.:.:.|::|:.                 ...|||::|  |.|.
Human  1539 --IIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQ 1601

  Fly  1817 FLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMS 1881
            ...|...       .|:....||:.|::.....||:      ||..|.| |::|.          
Human  1602 HDEHDED-------GSDMELDLLAAAETESDSESNH------SNQDNAS-GRRSV---------- 1642

  Fly  1882 LTSTSSDSEQVSLEDFLESCRAPALLGDLDDE--DDMDEDNDEEENEDEYEEVGNTLLQVMVSRN 1944
            :|:.::.||       ..:...||...:.|.:  |..|.|:...:::|..:|             
Human  1643 VTAATAGSE-------AGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQE------------- 1687

  Fly  1945 LLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELP 2009
              |||.||.:|.                                 .||.:..:.      .|:.|
Human  1688 --TFMLDEPLER---------------------------------TTNSSHANG------AAQAP 1711

  Fly  2010 KPQQ------------SGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCS 2062
            :..|            |..|.:...|...    ..|:..|....:..|.|..|...|....|:.|
Human  1712 RSMQWAVRNTQHQRAASTAPSSTSTPAAS----SAGLIYIDPSNLRRSGTISTSAAAAAAALEAS 1772

  Fly  2063 QLNKLDKFRKIWEPTYTIVYREVS-----------------PEAQEST---------CLESEEFP 2101
            ..:............|:||.|::|                 |.|.:.|         .:|.:..|
Human  1773 NASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIP 1837

  Fly  2102 ---------QTPDVSSKSGASTLS------PNSPMHIGFNVADN--------------------- 2130
                     .:.:...:.|::..|      ||.|:|...|.|..                     
Human  1838 TWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRAT 1902

  Fly  2131 -------------------------------------NLCSVDDVL----ELLTQINGLNQSE-- 2152
                                                 ::||:..|.    .|:..|..:||..  
Human  1903 LLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTL 1967

  Fly  2153 -----------------IDSDVKEHGVSVLSEDLFISKKITNKLQQQI------QDPLVLASNAL 2194
                             ||::..||   ...:|...|..:.:|....:      ..|....|:::
Human  1968 DTPQLERKRTRELLELGIDNEDSEH---ENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSM 2029

  Fly  2195 -------PNWCE-NLNQSCPF---------------LFPFETRQLYFNCTSFGASRSIVCLQSQR 2236
                   ||..| .|.::.|.               ||...::.||.:..|.|.     ||.   
Human  2030 TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGK-----CLM--- 2086

  Fly  2237 DVTVERQRIPIM---------------------------------------SPRRDD-------- 2254
            :|||:|..:.::                                       .|...|        
Human  2087 EVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSS 2151

  Fly  2255 ------------------------------HEFRIGR---------------------------- 2261
                                          |:..:||                            
Human  2152 LLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELG 2216

  Fly  2262 ---------------LKHER-----VKVPRNEDLLM-WAMQVMKTHCNRKSV--------LEVEF 2297
                           |::::     ::|.|:.|||: ..|:.:..|..|:..        ::|.|
Human  2217 GFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTF 2281

  Fly  2298 LDEEGTGLGPTLEFYALVA-AEIQRSDLCMWLCDDDLGEDTENSTQS-----AEGNSKPVGYYVN 2356
            .||.|.|.|....||..:| |.:....|....|..:..:.|..|...     .|.:.:.......
Human  2282 KDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREM 2346

  Fly  2357 RREHGI---------------------------------FPAPLPQNSEICENVL--KYFWFFGV 2386
            ||..|:                                 .|.|||.:.:.....|  :.......
Human  2347 RRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPA 2411

  Fly  2387 FVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSR---NLQKVIS-DRRNG-----DLSVVSEDSDIV 2442
            |.:|:..  .|:::..:...|.|...:.:.:|   .::.:|: .|.||     ||.:|.....:.
Human  2412 FASKITG--MLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQ 2474

  Fly  2443 ETCTK------------LLRTDSNKSNA-----------------------------FGGILSLE 2466
            :...|            |..||....||                             .|.||.|.
Human  2475 QENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLC 2539

  Fly  2467 NLKE---------------------------IDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKH 2504
            .|:.                           .||..|:.|::   |:|..||.:.|...||    
Human  2540 LLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQ---LILASQSSDADAVFSA---- 2597

  Fly  2505 ELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDN----LEAYCEL 2565
                              .|||.........   |..|.||:|||.::.||..|    :..|.|.
Human  2598 ------------------MDLAFAIDLCKEE---GGGQVELIPNGVNIPVTPQNVYEYVRKYAEH 2641

  Fly  2566 LMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMI--CGEQFPHWSREDIISYTEPKL 2628
            .|..:.:    |.:.|...|..:|.|...|...|..:.|:::  |||.    :.:.:||:|    
Human  2642 RMLVVAE----QPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV----NVQMLISFT---- 2694

  Fly  2629 GYNKDSP-------GFQR-FVNVLLSMSGDERKAFLQFTTGCSSLPPG--GLANLHPRLTVVRKV 2683
            .:|.:|.       .|:| |.:::..||..||:..:.|.|...|||..  |...: |.:|:....
Human  2695 SFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIRPPD 2758

  Fly  2684 DAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEKGF 2724
            |..:   |:.|||:..|.:|.|.:::|:|::||.|.|.|.|
Human  2759 DQHL---PTANTCISRLYVPLYSSKQILKQKLLLAIKTKNF 2796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 20/136 (15%)
MIB_HERC2 1333..1389 CDD:310955 7/55 (13%)
DamX 1576..>1725 CDD:330571 31/183 (17%)
HECTc 2265..2725 CDD:238033 130/608 (21%)
UBR5NP_056986.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..175 2/2 (100%)
CUE_UBR5 184..230 CDD:270606 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..352 0/23 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..648 10/68 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 999..1031 4/45 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1075 8/22 (36%)
ZnF_UBR1 1177..1244 CDD:197698 8/72 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1299..1318 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1515..1740 55/311 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1859..1890 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1984..2021 7/39 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2117..2142 1/24 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2323..2392 8/68 (12%)
PolyA 2389..2452 CDD:197769 11/64 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2473..2493 1/19 (5%)
HECTc 2501..2796 CDD:214523 80/338 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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