DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and HERC5

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_011530324.2 Gene:HERC5 / 51191 HGNCID:24368 Length:1100 Species:Homo sapiens


Alignment Length:1234 Identity:238/1234 - (19%)
Similarity:396/1234 - (32%) Gaps:428/1234 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1667 FPVPCTNVP--VGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKK-------PSVTLKPAQQ 1722
            ||: |:..|  ||.......::|::|.....::  ...|....:.|::       .:...:||:.
Human   118 FPL-CSATPEAVGALSPGTRRSLLSPLGLGPRK--AAMERRSRRKSRRNGRSTAGKAAATQPAKS 179

  Fly  1723 PNAVLSIVD---------IKEQPISNENVSVPSQMS--------ISVPNLTTTSAS--------- 1761
            |.|.|.:..         ::...::.:....|.:::        :.|..|...|..         
Human   180 PGAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKL 244

  Fly  1762 ----EVPSTSEVATHTGLLETFAAIARRRTSQGTNIQ-DNQIM---NAEANVNEH-------GDQ 1811
                ::.|..:.|.|..:|          :|.|...: ||..|   ..|:.:.|.       ||.
Human   245 GKNMKIHSVDQGAEHMLIL----------SSDGKPFEYDNYSMKHLRFESILQEKKIIQITCGDY 299

  Fly  1812 NASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNN-SENIAPSNPSNTSAGQQSASTIN 1875
            ::.....|..:     .|...|.| |.|...:.:||.::.. .|::|....:..|||:.      
Human   300 HSLALSKGGEL-----FAWGQNLH-GQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEA------ 352

  Fly  1876 HTLTMSLTST-----SSDSEQVSLEDFLESCRAPALLGDLDDEDD------------MDED---- 1919
            |::.:|::..     .::..|:.| ...||...|:|:..||::..            :.:|    
Human   353 HSMALSMSGNIYSWGKNECGQLGL-GHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLF 416

  Fly  1920 -----------NDEEENEDE----YEEVGNTLLQVMVSR-NLLTFMDD--------EAMENRL-V 1959
                       ::..:||..    .|.||..:.|:...| :.|.::.|        ...:.:| .
Human   417 TFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGN 481

  Fly  1960 GVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETI---- 2020
            |.|:     |:.:             |.|  ..|:.:.:|::....:|......:||.::|    
Human   482 GGTR-----DQLM-------------PLP--VKVSSSEELKLESHTSEKELIMIAGGNQSILLWI 526

  Fly  2021 --EQPLLGLKLRGPGI--GGIPEVEIDLSNTDW-TIFRAVQEL------LQCSQLNK-------- 2066
              |...:.||...|.:  |.:.....|:....| :..|.:||:      |..|.|.|        
Human   527 KKENSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPACLTGSFLRKRRTTEMMP 591

  Fly  2067 ----LDKFRKIWEPTYTIVYREVSPE----AQESTCLESEEFPQTPDVSSKSGAST---LSPNSP 2120
                |:|.|.|        ::|::.:    ...:|||:.....:.|..|....|..   |.|..|
Human   592 VYLDLNKARNI--------FKELTQKDWITNMITTCLKDNLLKRLPFHSPPQEALEIFFLLPECP 648

  Fly  2121 -MHIGFNVADNN-----------LCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISK 2173
             |||     .||           :|.:.|            ||.:   |.|...:.|.|..|   
Human   649 MMHI-----SNNWESLVVPFAKVVCKMSD------------QSSL---VLEEYWATLQESTF--- 690

  Fly  2174 KITNKLQQQIQDPLVLASNALPNWCEN---------LNQSCPFLFPFETRQLYFNCTSFGASR-S 2228
               :||.|..:..::.   .|..|.|:         |.:....|...:..:.|....:....| |
Human   691 ---SKLVQMFKTAVIC---QLDYWDESAEENGNVQALLEMLKKLHRSKKHKAYLRSAAIEEERES 749

  Fly  2229 IVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVL 2293
            ...|:...|:||.|..: |........:|             .||||             ||. |
Human   750 EFALRPTFDLTVRRNHL-IEDVLNQLSQF-------------ENEDL-------------RKE-L 786

  Fly  2294 EVEFLDEEGTGLGPTLE--FYALVAAEIQ---------RSDLCMWLCDDDLGEDTENSTQSAEGN 2347
            .|.|..|.|..||...:  ||.|.|..||         ....|||                    
Human   787 WVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMW-------------------- 831

  Fly  2348 SKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCH 2412
                           ||.. |:..:      |.::||||.....|.:..:.::|     ..|...
Human   832 ---------------FPVK-PKFEK------KRYFFFGVLCGLSLFNCNVANLP-----FPLALF 869

  Fly  2413 NKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQ 2477
            .|:|.:                                           :.|||:|||:.|...:
Human   870 KKLLDQ-------------------------------------------MPSLEDLKELSPDLGK 891

  Fly  2478 FLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQ 2542
            .||    .||..:...|::..                                |:..:..:....
Human   892 NLQ----TLLDDEGDNFEEVF--------------------------------YIHFNVHWDRND 920

  Fly  2543 AELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMI 2607
            ..|:|||||:.|...|...|....:|:|..|.:....:.|..||.::.....:..|.|.|.:.:|
Human   921 TNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVI 985

  Fly  2608 CGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLAN 2672
            .|.....|...:..:..||  |||...|....|......::.:|:|.||.|.||...|....|.|
Human   986 VGNTDYDWKTFEKNARYEP--GYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNN 1048

  Fly  2673 LHPRLTV-----------VRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTA-TKEKGF 2724
            :  ::|.           :|.:           ||...|.||.|.|.|.::|.|..| ...:||
Human  1049 M--KITFCCPESWNERDPIRAL-----------TCFSVLFLPKYSTMETVEEALQEAINNNRGF 1099

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041
MIB_HERC2 1333..1389 CDD:310955
DamX 1576..>1725 CDD:330571 13/66 (20%)
HECTc 2265..2725 CDD:238033 101/483 (21%)
HERC5XP_011530324.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.900

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