DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufd4 and Magi2

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006535806.1	Gene:	Magi2 / 50791	MGIID:	1354953	Length:	1414	Species:	Mus musculus

Alignment Length:	823	Identity:	152/823 - (18%)
Similarity:	257/823 - (31%)	Gaps:	307/823 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1614 ISKDLLANLRTSNIAG------------C-PPVTQLSTEALEMIDK----------MRDGVD--- 1652
            :|::||..:..:.:||            | .|:.....:...::||          .:..||
Mouse    61 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHEL 125

  Fly  1653 --MIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSV 1715
              :||:  |..|.|    ||||..|....:.|...           .|.:|.||| .:..|..::
Mouse   126 QQIIRD--NLYLRT----VPCTTRPHKEGEVPGVD-----------YIFITVEEF-MELEKSGAL 172

  Fly  1716 ------------TLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSE 1768
                        |.||..:|..:|::.| :..|.:..:.....:.:.||.|:...|. |.|...|
Mouse   173 LESGTYEDNYYGTPKPPAEPAPLLNVTD-QILPGATPSAEGKRKRNKSVTNMEKASI-EPPEEEE 235

  Fly  1769 VATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANV-----NEHGDQNASGSFLGHSVTSLVKL 1828
                                     ::..::|....|     :||.|::|..|  |.
Mouse   236 -------------------------EERPVVNGNGVVITPESSEHEDKSAGAS--GE-------- 265

  Fly  1829 ALSSNFHSGLLSTAQSYPSLSSNNSENI-------APSNPSN---------------TSAGQQSA 1871
                       :.:|.||:...:..|.:       .|:.|..               |..|:  .
Mouse   266 -----------TPSQPYPAPVYSQPEELKDQMDDTKPTKPEENEDSDPLPDNWEMAYTEKGE--V 317

  Fly  1872 STINHTLTMSLTSTSS--DSEQVSLEDFLESCRAPALLGDLDDEDD-------MDEDNDEEENED 1927
            ..|:|.     |.|:|  |..........|.|:...|....:..||       :|..|...:.|:
Mouse   318 YFIDHN-----TKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFEN 377

  Fly  1928 --------------EYEEVGNTLLQVMVSRNLLTFMDDEA-MENRLVGVTKRKS----------- 1966
                          .:.|:|...||....|....|..|.: ::...:..|.:||
Mouse   378 PVLEAKRKLQQHNMPHTELGAKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGG 442

  Fly  1967 -WDDEFVLKRQFSALIP----AFDPRP---------------GRTNVNQTSDLEISPLGAEL--- 2008
             ..|||:   |..::||    |.|.:.               |.|:.:.....:..|:|..:
Mouse   443 DEPDEFL---QVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLV 504

  Fly  2009 -----PKPQQSGGPETIEQPLLGLKLRGPG--IGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNK 2066
                 |.|.....|.....|.|.:..|.|.  :.|....|..|.    .|.|..|.:...:.
Mouse   505 LCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLE----YISRTSQSVPDITD--- 562

  Fly  2067 LDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPD--VSSKSGASTLSPNSPMHI------ 2123
                    .|.:::  ..:..:.|    |:....|...|  ||..|..:|.:....:.|
Mouse   563 --------RPPHSL--HSMPADGQ----LDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQG 613

  Fly  2124 -GFNVADN----------------NLCSVDDVLELLTQ-INGLNQSEIDSDVKEHGVS-----VL 2165
             ||.:||:                .||..|.::|:..| :..|:.:|:...:|:..|.     ::
Mouse   614 FGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLII 678

  Fly  2166 SEDLFIS-----KKITNKLQQQIQDPLVLASNALPNWCENLNQSCPF-------LFP-----FET 2213
            ....|.|     |.:.::.:.|......|::.|:|       |:.||       .||     |:.
Mouse   679 HRGGFFSPWKTPKPMMDRWENQGSPQTSLSAPAVP-------QNLPFPPALHRSSFPDSTEAFDP 736

  Fly  2214 R-----QLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPR 2251
            |     :||               :..|.:...||::|   ||
Mouse   737 RKPDPYELY---------------EKSRAIYESRQQVP---PR 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	32/150 (21%)
		HECTc	2265..2725	CDD:238033
Magi2	XP_006535806.1	PDZ_signaling	22..96	CDD:238492	7/34 (21%)
		NK	118..290	CDD:388413	45/237 (19%)
		WW	303..332	CDD:366073	7/35 (20%)
		WW	349..378	CDD:366073	6/28 (21%)
		PDZ	427..508	CDD:214570	15/83 (18%)
		PDZ	601..682	CDD:214570	14/80 (18%)
		MAGI_u5	681..755	CDD:374709	17/95 (18%)
		PDZ	774..860	CDD:214570
		PDZ_signaling	919..1006	CDD:238492
		PDZ_signaling	1138..1218	CDD:238492
		MAGI_u1	1245..1285	CDD:374706
		PHA03307	<1255..>1407	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900