DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and NEDD4

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_001271267.1 Gene:NEDD4 / 4734 HGNCID:7727 Length:1319 Species:Homo sapiens


Alignment Length:1567 Identity:298/1567 - (19%)
Similarity:516/1567 - (32%) Gaps:526/1567 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1422 SRKSSSTPSLPEATEKN---------QNPEGASNQTVSADNLAWKQT--VETIAENVFASAKTQI 1475
            :|:|::.| |.|.:..:         :.|...|...|....|..:||  ...|.|||.:..::.:
Human    11 ARRSNTYP-LSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAPLIKENVQSQERSSV 74

  Fly  1476 ISNQLAMNTSS----------------SREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLS 1524
            .|::.....||                |....|...::....:.||.|...:.:..||..::|..
Human    75 PSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKDGIYSSAVVDNELNAVNDGH 139

  Fly  1525 AINNSMPAINSSNVSDLATISENLSLTELSKE-NICRVLTPSYKPAESVTASQSSSHPDVQSSSP 1588
            .:  |.|||.|.::|:.:| |:|.|.:....: ..|..:|.......|| .|.|||:     :.|
Human   140 LV--SSPAICSGSLSNFST-SDNGSYSSNGSDFGSCASITSGGSYTNSV-ISDSSSY-----TFP 195

  Fly  1589 RENDIKNISNIEENNKMNANNSV-NKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVD 1652
            ..:|.....|:..::  .:|.|| |:            |...|...::.::....:.|.:..|::
Human   196 PSDDTFLGGNLPSDS--TSNRSVPNR------------NTTPCEIFSRSTSTDPFVQDDLEHGLE 246

  Fly  1653 M------------IRNMSNSIL-------STDTFPVP-CTNVPVGGKKTPKAQALINP------- 1690
            :            ::..|:.::       :..|.|.. ||.:..|..:| ..|.:|:|       
Human   247 IMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQT-SHQFIISPSEIAHNE 310

  Fly  1691 DNANQKQIIVT-------SEEFPTKSSKKPSVTL--KPAQQPNAVLSIVDIKEQPI---SNENVS 1743
            |..:.|..:.|       |:...|....:....|  |.:.|...||| .:...|.:   |:|..|
Human   311 DGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLS-NNTPRQTVCEKSSEGYS 374

  Fly  1744 VPS----QMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEAN 1804
            ..|    |...:..:..||:....|..||:..::   ::.......|||  ..:..:|.::.:.|
Human   375 CVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNS---DSEYIKLMHRTS--ACLPSSQNVDCQIN 434

  Fly  1805 VN-----EHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLS--SNNSENIAPSNPS 1862
            :|     .|...|.:...|..|:                 |...:||::|  |:...|.:...||
Human   435 INGELERPHSQMNKNHGILRRSI-----------------SLGGAYPNISCLSSLKHNCSKGGPS 482

  Fly  1863 NT----SAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRA-PALLGDLD----------- 1911
            ..    ::|.:.          .:.:.|.||.:....:...||:. ...||.:|           
Human   483 QLLIKFASGNEG----------KVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENP 537

  Fly  1912 --------------------------------------DEDDMDEDNDE---------------- 1922
                                                  .|||..|..:|                
Human   538 RLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACH 602

  Fly  1923 --------------EENED--------EYE------------------EVGNTLLQ---VMVSRN 1944
                          ||.:|        .:|                  |.||..||   ...:|.
Human   603 LQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRR 667

  Fly  1945 LLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALI--PAFDPRPGRTNVNQTSDLEISPLGAE 2007
            .:: .:.|:::||    ...::|:   :::...:.:.  .||...|..:|::..:.| ...|.|.
Human   668 QIS-EETESVDNR----ESSENWE---IIREDEATMYSNQAFPSPPPSSNLDVPTHL-AEELNAR 723

  Fly  2008 L--------PKPQQSGGPET----------IEQPLLGLKLRGPGIGGIPE--------------V 2040
            |        .:|..|....:          .|||.|.:.|  |...|:|.              |
Human   724 LTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLL--PTSSGLPPGWEEKQDERGRSYYV 786

  Fly  2041 EIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPD 2105
            :.:...|.|| ...||..::.|||              |.......|::|.||....::..|..:
Human   787 DHNSRTTTWT-KPTVQATVETSQL--------------TSSQSSAGPQSQASTSDSGQQVTQPSE 836

  Fly  2106 VSS----KSGASTLSPNS-PMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVL 2165
            :..    |......:||. |..|..|......  .|..|::...:.|  ::.:|:          
Human   837 IEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTW--EDPRLKIPAHLRG--KTSLDT---------- 887

  Fly  2166 SEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIV 2230
            |.||               .||.      |.|.|..:.        :.|..|.|       .:|.
Human   888 SNDL---------------GPLP------PGWEERTHT--------DGRIFYIN-------HNIK 916

  Fly  2231 CLQSQ----RDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNR-- 2289
            ..|.:    .:|.:....:|.....:..:||...:||.:. .:|...::.:....|::....|  
Human   917 RTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQN-DIPNKFEMKLRRATVLEDSYRRIM 980

  Fly  2290 --------KSVLEVEFLDEEGTGLGPTL-EFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAE 2345
                    |:.|.:||..|:|...|... |::.|::.|:...                       
Human   981 GVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNP----------------------- 1022

  Fly  2346 GNSKPVGYYVNRREHGIF--------PAPLPQNSEIC-ENVLKYFWFFGVFVAKVLQDMRLVDIP 2401
                   ||      |:|        ...:..||.:| |:.|.||.|.|......:...:|:|..
Human  1023 -------YY------GLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGF 1074

  Fly  2402 LSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLE 2466
            ....|.:::.|..:...:::.|.|:..|                                  ||.
Human  1075 FIRPFYKMMLHKPITLHDMESVDSEYYN----------------------------------SLR 1105

  Fly  2467 NLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTY 2531
            .:.|.|||                                  ||.|:                 :
Human  1106 WILENDPT----------------------------------ELDLR-----------------F 1119

  Fly  2532 LPSSSIYGYT-QAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKL 2595
            :....::|.| |.||...||.:.||..|.:.|..|::.:...:.|.:||.||.:||.|:.|...:
Human  1120 IIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 1184

  Fly  2596 AAFTPSEARMMICG---EQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQ 2657
            ..|..:|..:::||   .....| ||    :|:.|.||:.:....|.|...:|.|..::|...||
Human  1185 KIFDENELELLMCGLGDVDVNDW-RE----HTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQ 1244

  Fly  2658 FTTGCSSLPPGGLANLH----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTA 2718
            |.||.|.:|..|.|.|:    |:...|.:... ....|..:||.:.|.||.|.:.|.:.::|..|
Human  1245 FVTGTSRVPMNGFAELYGSNGPQSFTVEQWGT-PEKLPRAHTCFNRLDLPPYESFEELWDKLQMA 1308

  Fly  2719 TKE-KGF 2724
            .:. :||
Human  1309 IENTQGF 1315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041
MIB_HERC2 1333..1389 CDD:310955
DamX 1576..>1725 CDD:330571 32/185 (17%)
HECTc 2265..2725 CDD:238033 103/489 (21%)
NEDD4NP_001271267.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..229 7/38 (18%)
C2 <517..570 CDD:417471 3/52 (6%)
Mediates interaction with TNIK. /evidence=ECO:0000250 578..981 83/479 (17%)
WW 611..643 CDD:197736 4/31 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 755..780 8/26 (31%)
WW 769..798 CDD:395320 5/29 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 796..834 11/52 (21%)
WW 842..871 CDD:395320 6/30 (20%)
WW 893..925 CDD:197736 10/52 (19%)
HECTc 986..1315 CDD:214523 98/455 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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