Protein Alignment Ufd4 and Nedd4

DIOPT Version :10

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 1446
• Identity: 250/1446 - (17%)
• Similarity: 410/1446 - (28%)
• Gaps: 640/1446 - (44%)

  Fly  1306 GKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDH 1370
            |:::.| ::.|.|.||.:.|:.:...| .|:.........||...:.|...||         |:|
  Fly   171 GRTIGE-QSYTLRPRRSVGAKSRIKGT-LRIYHAFIRETREQSEPSSGNSDGE---------WEH 224

  Fly  1371 GVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEAT 1435
                                .|..:|       |..|....|...||:          .:||...
  Fly   225 --------------------VEATNA-------GETSAQPHPFPTGGH----------DALPAGW 252

  Fly  1436 EKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTN 1500
            |:.|:   |:.:|...::.|  :|.:.....|..|..:|...:|||.:............|||.:
  Fly   253 EERQD---ANGRTYYVNHTA--RTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRS 312

  Fly  1501 QMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPS 1565
               .|:||                  :||:.  :::|.:.||
  Fly   313 ---ADSIS------------------HNSIE--DNNNAAGLA----------------------- 331

  Fly  1566 YKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGC 1630
            |.|.   ||:.||:.|                    |...|.|..:.:|:
  Fly   332 YTPK---TAATSSAPP--------------------NTPTNNNGILAQIA--------------- 358

  Fly  1631 PPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQ 1695
                 :...|.|..|...|....:.|                             :|.:|....|
  Fly   359 -----MQYRAEEDQDPTVDHTSFVYN-----------------------------SLRHPVAHRQ 389

  Fly  1696 KQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSA 1760
            .:|..||.:          ..|:|            ::|.|              .||::..|:.
  Fly   390 PEISATSLQ----------NDLRP------------VREAP--------------GVPDIAITNP 418

  Fly  1761 SEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVN------EHGDQNASGSFLG 1819
            ....:...:|...|..:     .|||.....:||.:|....:...|      :|..|...
  Fly   419 FTRRAAGNMAGGAGWQQ-----ERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQ----- 473

  Fly  1820 HSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTS 1884
                           |.|.....|..|  |:.::::....|||:.||                .|
  Fly   474 ---------------HRGQRHQQQHRP--SNEDTDHTDSHNPSDISA----------------PS 505

  Fly  1885 TSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFM 1949
            |..:||:       ::...|.:                |:|....||.......:.|:.|..||.
  Fly   506 TRRNSEE-------DNAAVPPM----------------EQNTGGEEEPLPPRWSMQVAPNGRTFF 547

  Fly  1950 DDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQS 2014
            .|.|        ::|.:|                .|||.||.:                |.|.|:
  Fly   548 IDHA--------SRRTTW----------------IDPRNGRAS----------------PMPNQT 572

  Fly  2015 GGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYT 2079
               ..:|..|          |.:||...:..:||..:|..
  Fly   573 ---RRVEDDL----------GPLPEGWEERVHTDGRVFYI------------------------- 599

  Fly  2080 IVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQ 2144
                                                                             
  Fly   600 ----------------------------------------------------------------- 599

  Fly  2145 INGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLF 2209
                          :|                |....|.:||.:  ||  ||..   .|:.|:..
  Fly   600 --------------DH----------------NTRTTQWEDPRL--SN--PNIA---GQAVPYSR 627

  Fly  2210 PFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNED 2274
            .::.:..||                         :..|..|....::|.| |::...:.    ||
  Fly   628 DYKQKYEYF-------------------------KSHIRKPTNVPNKFEI-RIRRTSIL----ED 662

  Fly  2275 LLMWAMQVMKTHCNRKSVLEVEFLDEEGTGL---GPTLEFYALVAAEIQRSDLCMWLCDDDLGED 2336
            .......|.||.. .|:.|.|||  |..|||   |...|::.|::.|:...
  Fly   663 SYRIISSVTKTDL-LKTKLWVEF--EGETGLDYGGLAREWFYLLSKEMFNP-------------- 710

  Fly  2337 TENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQN--------SEIC-ENVLKYFWFFGVFVAKVL 2392
                            ||      |:|......|        |.:| |..|.||.|.|......:
  Fly   711 ----------------YY------GLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAV 753

  Fly  2393 QDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSN 2457
            ...:|:|......|.:::....:..::::.|.::..|
  Fly   754 YHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYN---------------------------- 790

  Fly  2458 AFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSL 2522
                  ||..:||.||.
  Fly   791 ------SLMWIKENDPR------------------------------------------------ 801

  Fly  2523 EDLALTFTYLPSSSIYGY-TQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGF 2586
               .|..|:.....::|. :|.||.|.|::::||.:|.:.|.:|::.:.....:.:||.:|.|||
  Fly   802 ---ILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGF 863

  Fly  2587 NEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKL---GYNKDSPGFQRFVNVLLSMS 2648
            ..:.||..:..|...|..:::||.|     ..|:..:.|..|   .|:.:....|.|...:||.|
  Fly   864 GSIIPLNLIKIFDEHELELLMCGIQ-----NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFS 923

  Fly  2649 GDERKAFLQFTTGCSSLPPGGLANLH----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEE 2709
            .:.|...|||.||.|.:|..|...|:    |::..:.|... ..::|..:||.:.|.||.|....
  Fly   924 NEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGT-PNNFPRAHTCFNRLDLPPYEGYL 987

  Fly  2710 IMKERLLTATK-EKGF 2724
            .:|::|:.|.: .:||
  Fly   988 QLKDKLIKAIEGSQGF 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANKYR	<375..>509	CDD:440430
		ANK repeat	393..420	CDD:293786
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		Sad1_UNC	1173..1298	CDD:474037
		MIB_HERC2	1333..1390	CDD:461991	8/56 (14%)
		HECTc	2265..2725	CDD:238033	101/481 (21%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	9/34 (26%)
		WW	248..277	CDD:459800	8/33 (24%)
		HUL4	<523..1003	CDD:227354	144/819 (18%)