DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and Nedd4

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster


Alignment Length:1446 Identity:250/1446 - (17%)
Similarity:410/1446 - (28%) Gaps:640/1446 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly  1306 GKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDH 1370
            |:::.| ::.|.|.||.:.|:.:...| .|:.........||...:.|...||         |:|
  Fly   171 GRTIGE-QSYTLRPRRSVGAKSRIKGT-LRIYHAFIRETREQSEPSSGNSDGE---------WEH 224

  Fly  1371 GVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEAT 1435
                                .|..:|       |..|....|...||:          .:||...
  Fly   225 --------------------VEATNA-------GETSAQPHPFPTGGH----------DALPAGW 252

  Fly  1436 EKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTN 1500
            |:.|:   |:.:|...::.|  :|.:.....|..|..:|...:|||.:............|||.:
  Fly   253 EERQD---ANGRTYYVNHTA--RTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRS 312

  Fly  1501 QMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPS 1565
               .|:||                  :||:.  :::|.:.||                       
  Fly   313 ---ADSIS------------------HNSIE--DNNNAAGLA----------------------- 331

  Fly  1566 YKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGC 1630
            |.|.   ||:.||:.|                    |...|.|..:.:|:               
  Fly   332 YTPK---TAATSSAPP--------------------NTPTNNNGILAQIA--------------- 358

  Fly  1631 PPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQ 1695
                 :...|.|..|...|....:.|                             :|.:|....|
  Fly   359 -----MQYRAEEDQDPTVDHTSFVYN-----------------------------SLRHPVAHRQ 389

  Fly  1696 KQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSA 1760
            .:|..||.:          ..|:|            ::|.|              .||::..|:.
  Fly   390 PEISATSLQ----------NDLRP------------VREAP--------------GVPDIAITNP 418

  Fly  1761 SEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVN------EHGDQNASGSFLG 1819
            ....:...:|...|..:     .|||.....:||.:|....:...|      :|..|...     
  Fly   419 FTRRAAGNMAGGAGWQQ-----ERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQ----- 473

  Fly  1820 HSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTS 1884
                           |.|.....|..|  |:.::::....|||:.||                .|
  Fly   474 ---------------HRGQRHQQQHRP--SNEDTDHTDSHNPSDISA----------------PS 505

  Fly  1885 TSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFM 1949
            |..:||:       ::...|.:                |:|....||.......:.|:.|..||.
  Fly   506 TRRNSEE-------DNAAVPPM----------------EQNTGGEEEPLPPRWSMQVAPNGRTFF 547

  Fly  1950 DDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQS 2014
            .|.|        ::|.:|                .|||.||.:                |.|.|:
  Fly   548 IDHA--------SRRTTW----------------IDPRNGRAS----------------PMPNQT 572

  Fly  2015 GGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYT 2079
               ..:|..|          |.:||...:..:||..:|..                         
  Fly   573 ---RRVEDDL----------GPLPEGWEERVHTDGRVFYI------------------------- 599

  Fly  2080 IVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQ 2144
                                                                             
  Fly   600 ----------------------------------------------------------------- 599

  Fly  2145 INGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLF 2209
                          :|                |....|.:||.:  ||  ||..   .|:.|:..
  Fly   600 --------------DH----------------NTRTTQWEDPRL--SN--PNIA---GQAVPYSR 627

  Fly  2210 PFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNED 2274
            .::.:..||                         :..|..|....::|.| |::...:.    ||
  Fly   628 DYKQKYEYF-------------------------KSHIRKPTNVPNKFEI-RIRRTSIL----ED 662

  Fly  2275 LLMWAMQVMKTHCNRKSVLEVEFLDEEGTGL---GPTLEFYALVAAEIQRSDLCMWLCDDDLGED 2336
            .......|.||.. .|:.|.|||  |..|||   |...|::.|::.|:...              
  Fly   663 SYRIISSVTKTDL-LKTKLWVEF--EGETGLDYGGLAREWFYLLSKEMFNP-------------- 710

  Fly  2337 TENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQN--------SEIC-ENVLKYFWFFGVFVAKVL 2392
                            ||      |:|......|        |.:| |..|.||.|.|......:
  Fly   711 ----------------YY------GLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAV 753

  Fly  2393 QDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSN 2457
            ...:|:|......|.:::....:..::::.|.::..|                            
  Fly   754 YHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYN---------------------------- 790

  Fly  2458 AFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSL 2522
                  ||..:||.||.                                                
  Fly   791 ------SLMWIKENDPR------------------------------------------------ 801

  Fly  2523 EDLALTFTYLPSSSIYGY-TQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGF 2586
               .|..|:.....::|. :|.||.|.|::::||.:|.:.|.:|::.:.....:.:||.:|.|||
  Fly   802 ---ILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGF 863

  Fly  2587 NEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKL---GYNKDSPGFQRFVNVLLSMS 2648
            ..:.||..:..|...|..:::||.|     ..|:..:.|..|   .|:.:....|.|...:||.|
  Fly   864 GSIIPLNLIKIFDEHELELLMCGIQ-----NIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFS 923

  Fly  2649 GDERKAFLQFTTGCSSLPPGGLANLH----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEE 2709
            .:.|...|||.||.|.:|..|...|:    |::..:.|... ..::|..:||.:.|.||.|....
  Fly   924 NEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGT-PNNFPRAHTCFNRLDLPPYEGYL 987

  Fly  2710 IMKERLLTATK-EKGF 2724
            .:|::|:.|.: .:||
  Fly   988 QLKDKLIKAIEGSQGF 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041
MIB_HERC2 1333..1389 CDD:310955 8/55 (15%)
DamX 1576..>1725 CDD:330571 20/148 (14%)
HECTc 2265..2725 CDD:238033 101/481 (21%)
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 9/34 (26%)
WW 248..277 CDD:278809 8/33 (24%)
WW 531..560 CDD:278809 8/52 (15%)
WW 581..613 CDD:197736 10/151 (7%)
HECTc 650..1003 CDD:238033 102/487 (21%)
HECTc 674..1003 CDD:214523 94/458 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446996
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.830

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