DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufd4 and yki

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	94/557 - (16%)
Similarity:	168/557 - (30%)	Gaps:	207/557 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1614 ISKDLLANLRTSNIAGCPPVTQL--STEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTN--V 1674
            |:|.:|.:.|...|:....:|.:  |:....:|:|..|..||:.            |:...|  |
  Fly     6 IAKIILCSFRLYTISAFYMLTTMSASSNTNSLIEKEIDDEDMLS------------PIKSNNLVV 58

  Fly  1675 PVGGKKTPKAQAL----INPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQ 1735
            .|........|||    :||.:|.:..      :.|.:..|.|:....|....::..:..|....
  Fly    59 RVNQDTDDNLQALFDSVLNPGDAKRPL------QLPLRMRKLPNSFFTPPAPSHSRANSADSTYD 117

  Fly  1736 PISNENVSVPSQMSI-----------SVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQ 1789
            ..|..::::.::.||           ::|.|....:   |..|.:|.|..          |..|.
  Fly   118 AGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPS---PQHSRLAIHHS----------RARSS 169

  Fly  1790 GTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSE 1854
            ..::|.|..:.|.::.....:.||:.|                         :|..|:
  Fly   170 PASLQQNYNVRARSDAAAANNPNANPS-------------------------SQQQPA------- 202

  Fly  1855 NIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDED 1919
              .|:.|.|                             |.::|.....|.:.: |||
  Fly   203 --GPTFPEN-----------------------------SAQEFPSGAPASSAI-DLD-------- 227

  Fly  1920 NDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWD--DEFVLKRQFSALIP 1982
                        ..||.:...:..::.|..            .|::|:|  ....|.||..||.|
  Fly   228 ------------AMNTCMSQDIPMSMQTVH------------KKQRSYDVISPIQLNRQLGALPP 268

  Fly  1983 AFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNT 2047
            .::..       :|:|.:|..|.......|...                      |.::
  Fly   269 GWEQA-------KTNDGQIYYLNHTTKSTQWED----------------------PRIQ------ 298

  Fly  2048 DWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVS--PEAQESTCLESEEFPQTPDVSSKS 2110
                :|..|::|...::.:.|..:...:.|.:.:...:.  |:..|....||.:......:.
  Fly   299 ----YRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVTESGDLYFINHID--- 356

  Fly  2111 GASTLSPNSP-MHIGFNVAD------------NNLCS 2134
              .|.|.|.| |..|.:|.|            :||||
  Fly   357 --RTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDNLCS 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	26/118 (22%)
		HECTc	2265..2725	CDD:238033
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	32/175 (18%)
		WW	266..295	CDD:395320	7/57 (12%)
		WW	335..364	CDD:395320	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900