DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Hectd1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006240148.1	Gene:	Hectd1 / 362736	RGDID:	1561653	Length:	2610	Species:	Rattus norvegicus

Alignment Length:	2899	Identity:	1398/2899 - (48%)
Similarity:	1793/2899 - (61%)	Gaps:	461/2899 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDVDPETLLEWLSMGQGDERDMQLIALEQLCMLLLMSDNVDRCFESCPPRTFLPALCKIFLDEL 65
            |.||||:||||||.||||||||||||||||||||||||||||||||:|||||||||||||||||.
  Rat     1 MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDES 65

  Fly    66 APENVLEVTARAITYYLDVSAECTRRIVSIDGAIKAICNHLVVADLSSRTSRDLAEQCIKVLELI 130
            ||:|||||||||||||||||||||||||.:||||||:||.|||.:|::||||||||||:||||||
  Rat    66 APDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELI 130

  Fly   131 CTREAGAVFEGGGLNCVLSFIRDCGSQVHKDTLHSAMSVVSRLCTKVEPNTPCIQNCVESLSTLL 195
            ||||:|||||.|||||||:||||.|..||||||||||:||||||.|:||....::.||||||:||
  Rat   131 CTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLSSLL 195

  Fly   196 QHEDPMVSDGALKCFASVADRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTS 260
            :|||..||||||:||||:||||||:.|||||||::|||.|||.|:.:.||      |.:|  |:|
  Rat   196 KHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGG------TVSG--PSS 252

  Fly   261 SSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRS 325
            :.:|..:|..   ..:.|..:.:||              .:||.:|||||||||||.:|||:|||
  Rat   253 ACKPGRSTTG---APSAAADSKLSN--------------QVSTIVSLLSTLCRGSPLVTHDLLRS 300

  Fly   326 QLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTH 390
            :|.|::|.|||||||||||.||..||||:||||||:||.:.|.. :.|:: |..||.:::.:|:|
  Rat   301 ELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAG-STGRI-PGLRRLDSSGERSH 363

  Fly   391 RQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQRS 455
            |||||||||||::||.:||::|..:||.|||||||||||||||||.||||:|||:|||||:||||
  Rat   364 RQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRS 428

  Fly   456 SSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSPDH 520
            ||||||||||||.:||.||:.||.||||||||||||||||||   ||.||.|||||||:||.|
  Rat   429 SSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARER---GHSEVVAILQSPGDWMCP-- 488

  Fly   521 SLLNK-DGKK--------YTLMEPRGDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKKI 576
              :|| |.||        ....||:|||||||:|||.|||:|.:||..:||.|:|:||||||:|:
  Rat   489 --VNKGDDKKKKDTNKDEEECNEPKGDPEMAPVYLKRLLPVFAQTFQHTMLPSIRKASLALIRKM 551

  Fly   577 VQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIEEIMCKTQ 641
            :.:.        ||....|...|.:|.|....|:|:.|:|||.|||.||||:.|.||.:::.|..
  Rat   552 IHFC--------SEALLKEVCDSDAGHNLPTALVEITATVLDQEDDDDGHLLALQIIRDLVDKGG 608

  Fly   642 EEFLDHFARLGVFAKVQALMDTDAEELYVQLPGTVEEPAAAQRSSTSVVVAPRPTSDDPMEDAKE 706
            :.|||..|||||.:||.||....:::       ..||.:..::            .|:|.|||||
  Rat   609 DIFLDQLARLGVISKVSALAGPSSDD-------ENEEESKPEK------------EDEPQEDAKE 654

  Fly   707 ILQGKPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSE 771
            :.||||||||:||:.|||||||:|||:.|||||||||||||||:||||||||||||||.|:||||
  Rat   655 LQQGKPYHWRDWSVIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSE 719

  Fly   772 NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDD 836
            :|.||||||.|||..|.....|||||......:|.||||.|...|..::.|||::|.|.|:|::|
  Rat   720 SRSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATILKED 784

  Fly   837 LPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQ 901
            ||||:|||||||||:|:|||.||.:|.:||:..:.::.|||.|..|.:||.::|::|:.:||:.:
  Rat   785 LPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDLYDDHFKAVE 849

  Fly   902 IIPRGAVAILTDIVKQIELSFE----EQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSS 962
            .:|||.|..|.:|..|:|.|:|    .|.:.....|...:..||..|..|:.::..:|.|||.||
  Rat   850 SMPRGVVVTLRNIATQLESSWELHTNRQCIEGENTWRDLMKTALENLIVLLKDESTISPYEMCSS 914

  Fly   963 GLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQKLV 1027
            ||||||:.||:.:........|.:   ..:|::|||....|.  |...::|     |..||:||:
  Rat   915 GLVQALLTVLNSSIDLDMKQDCSQ---LVERINVFKTAFSES--EDDESRP-----AVALIRKLI 969

  Fly  1028 SVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKY 1092
            :||||.|:||::|||:|.:.|:||||.:|||||||||..|:.|.||:||.||||||||:..|.:|
  Rat   970 AVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETALIDRTGRMLKMEPLATVESLEQY 1034

  Fly  1093 LLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTC-DWVNPAQYGL 1156
            |||||||||||.|||::.:::|:||.:. .:|.|..||||.|::::||:||||. :|||||.|||
  Rat  1035 LLKMVAKQWYDFDRSSFVFVRKLREGQN-FIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGL 1098

  Fly  1157 VQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSAL 1221
            |.||||||:.||||:||||||||:.:||||:.|:|.|||||||||::||:|||||||||||||||
  Rat  1099 VVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAIDLGVWVIPSAYTLRHARGYGRSAL 1163

  Fly  1222 RNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHY 1286
            |||:.|.||||..||:|.|||||.||.|||||||||::.|.|:...:||:|::|.|:||||||||
  Rat  1164 RNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPLDPAKDEKQGWRHVRLKQMGKNASGQTHY 1228

  Fly  1287 LSLSGFEIYGRVVGVADD-IGKSVKEAEAKTRRERRQIRAQ-LKHMTTGARVIRGVDWRWEEQDG 1349
            |||||||:||.|.||.:| :||:.|||||..||:||.:|:| ||:|..|||||||:||:|.:|||
  Rat  1229 LSLSGFELYGTVNGVCEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDG 1293

  Fly  1350 C--AEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKP 1412
            .  .|||:|||:|||||||.||.|..||||||||||:|||||     ..:|       ..|.|.|
  Rat  1294 SPQGEGTVTGELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLA-----PGYD-------PDTVASP 1346

  Fly  1413 SEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIIS 1477
                 ..::|..|.:|.|. .:..||..|:..|....|:.......:|.::|.           |
  Rat  1347 -----KPVSSTVSGTTQSW-SSLVKNNCPDKTSAAAGSSSRKGSSSSVCSVAS-----------S 1394

  Fly  1478 NQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLA 1542
            :.:::. |:..|.|::      ..|....:|| :.:...:..:|  ||.|.....:.||:.:..:
  Rat  1395 SDISLG-STKTERRSE------IVMEHSIVSG-ADVHEPIVVLS--SAENVPQTEVGSSSSASTS 1449

  Fly  1543 TISENLSLTELSKENICRVLTPSYK---PAESVTASQ---SSSHPDVQSSSPRENDIKNISNIEE 1601
            |::     .|...||..|.|.|...   |.||...|.   |.|.|||.|.|
  Rat  1450 TLT-----AETGSENAERKLGPDSSVRAPGESSAISMGIVSVSSPDVSSVS-------------- 1495

  Fly  1602 NNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDT 1666

  Rat  1496 ----------------------------------------------------------------- 1495

  Fly  1667 FPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVD 1731
                               .|.|.:.|:|:         |..||         |....:|.|::
  Rat  1496 -------------------ELTNKEAASQR---------PLSSS---------ASNRLSVSSLL- 1522

  Fly  1732 IKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDN 1796
                     ....|...|.|||||::...|.:.|         .:...|.|||      ||..:|
  Rat  1523 ---------AAGAPMSSSASVPNLSSRETSSLES---------FVRRVANIAR------TNATNN 1563

  Fly  1797 QIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSS-NNSENIAPSN 1860
            .      |::.....|.:.: ||.:|.|..         :..|..|||:|:|:: ..:..:..|.
  Rat  1564 M------NLSRSSSDNNTNT-LGRNVMSTA---------TSPLMGAQSFPNLTTPGTTSTVTMST 1612

  Fly  1861 PSNTSAGQQSAST--------INHTLTMSLTSTSSDSE-----QVSLEDFLESCRAPALLGDLDD 1912
            .|.||:...:.:|        :::|||.|||||||:|:     :.||.|||:||||..||.:|||
  Rat  1613 SSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDD 1677

  Fly  1913 EDDMDE-DNDEEENED------EYEE-----------------------VGNTLLQVMVSRNLLT 1947
            ::|:.| |.:::||||      ||||                       |.:.|.||........
  Rat  1678 DEDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPSGAGSRP 1742

  Fly  1948 FMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQ 2012
            ..:.|..|....| .:|::|||::|||||||||:||||||||||||.||:||||.|.|.  |..:
  Rat  1743 IGEQEEEEYETKG-GRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT--PHSE 1804

  Fly  2013 QSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQ--CSQLNKLDKFRKIWE 2075
            .....|....|.|.|.|:..|:|...|||:.|||...|||..||:|||  |:...|.||.|:|||
  Rat  1805 LLEEVECTPSPRLALTLKVTGLGTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWE 1869

  Fly  2076 PTYTIVYREVSPEAQEST-----C---------LESEEFPQTPDV-------------------S 2107
            |||||:|||:....:|..     |         |.::|.|:...:                   :
  Rat  1870 PTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGT 1934

  Fly  2108 SKS----------------------------GAST---------LSPNSPMHIGFNVADNNLCSV 2135
            :||                            |||:         |:...|.....|  ..|.|.|
  Rat  1935 NKSIRKNRNCSQLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKAGN--GQNPCGV 1997

  Fly  2136 DDVLELLTQI--------NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASN 2192
            :|||:||..:        :.::|.:.|    |........|.|.|||||.|:.|||::||.|||.
  Rat  1998 EDVLQLLRILYIVASDPYSRISQEDGD----EQPQFTFPPDEFTSKKITTKILQQIEEPLALASG 2058

  Fly  2193 ALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDD-HE 2256
            |||:|||.|...||||.|||||||||.||:|||||:||.||::|:.||||.| ...|.|||| .|
  Rat  2059 ALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTR-TTSSVRRDDPGE 2122

  Fly  2257 FRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQR 2321
            ||:||||||||||||.|.|:.||..||:.|.:||||||||||.|||||||||||||||||||.||
  Rat  2123 FRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQR 2187

  Fly  2322 SDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGV 2386
            :||..|||||:..:| |:......|..||.|||| :|..|:|.||.||:|:..|.:.|.|.|.|:
  Rat  2188 TDLGTWLCDDNFPDD-ESRHVDLGGGLKPPGYYV-QRSCGLFTAPFPQDSDELERITKLFHFLGI 2250

  Fly  2387 FVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGD-------------------- 2431
            |:||.:||.||||:|:|..|.:|:|...:.| |:.|:|.:.| ||
  Rat  2251 FLAKCIQDNRLVDLPISKPFFKLMCMGDIKS-NMSKLIYESR-GDRDLHCTESQSEASTEEGHDS 2313

  Fly  2432 LSVVSEDSDIVETCTKLLRTDSNKSNA-FGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFD 2495
            |||.|.:.|  .....:|.....|..| |.|||:.|:.:.::|.|.:||:|:::|.::::.|..:
  Rat  2314 LSVGSFEED--SKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGN 2376

  Fly  2496 DTISAEKKHELINELKLQTQNGL--EVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDN 2558
            .::|.::|:..:.||.|:..:|.  .:|:|||.|.|.:.|||.|||:|..:|.|:|....:|:||
  Rat  2377 KSLSEDEKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDN 2441

  Fly  2559 LEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISY 2623
            .|.|.:|:.:|.:..||.:||:||.||||:|||::||::|:..|.:|::||.|.|.|:.||||:|
  Rat  2442 AEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINY 2506

  Fly  2624 TEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVG 2688
            |||||||.:|||||.|||.||..||.||||||||||||||:|||||||||||||||||||||...
  Rat  2507 TEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDA 2571

  Fly  2689 SYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEKGFHLN 2727
            |||||||||||||||:|.:||||:||||.||.|||||||
  Rat  2572 SYPSVNTCVHYLKLPEYSSEEIMRERLLAATMEKGFHLN 2610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	16/26 (62%)
		ANK	396..509	CDD:238125	87/112 (78%)
		ANK repeat	422..453	CDD:293786	26/30 (87%)
		ANK repeat	455..484	CDD:293786	22/28 (79%)
		F5_F8_type_C	1173..1298	CDD:329041	90/124 (73%)
		MIB_HERC2	1333..1389	CDD:310955	42/57 (74%)
		DamX	1576..>1725	CDD:330571	15/151 (10%)
		HECTc	2265..2725	CDD:238033	255/482 (53%)
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560	70/90 (78%)
		ANK repeat	366..393	CDD:293786	16/26 (62%)
		ANK	369..479	CDD:238125	87/112 (78%)
		ANK repeat	396..426	CDD:293786	25/29 (86%)
		ANK repeat	428..457	CDD:293786	22/28 (79%)
		F5_F8_type_C	1107..1240	CDD:304887	95/132 (72%)
		MIB_HERC2	1277..1335	CDD:284184	42/57 (74%)
		HECTc	2131..2608	CDD:238033	255/482 (53%)
		HECTc	2155..2607	CDD:214523	240/457 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346098
Domainoid	1	1.000	625	1.000	Domainoid score	I168
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9115
Inparanoid	1	1.050	2238	1.000	Inparanoid score	I35
OMA	1	1.010	-	-		QHG52632
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	1	1.000	-	-		FOG0006411
OrthoInspector	1	1.000	-	-		oto95914
orthoMCL	1	0.900	-	-		OOG6_107049
Panther	1	1.100	-	-	LDO	PTHR45670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4675
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770