DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and HERC2

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster


Alignment Length:2756 Identity:519/2756 - (18%)
Similarity:850/2756 - (30%) Gaps:1033/2756 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 SIDGAIKAICNHLVV-ADLSSRTSRDLAEQCIKVLELICTREAGAVF---EG-----GGLNC--- 146
            |:...:.|:.:|:|| ..|.|..:..||          .|.| |.||   :|     |..||   
  Fly   709 SLPTLVVALSDHMVVDVALGSGDAHSLA----------LTSE-GLVFAWGDGDYGKLGNGNCNGS 762

  Fly   147 -----VLSFIR----DCGSQVHKDTLHSAMSVVSRLCT----------KVEPNTPCIQNC-VESL 191
                 |.|..|    ..|||     ...|:|...:|.|          .||.:   :|.| |..|
  Fly   763 LQPILVESLPRVQRVFAGSQ-----FSVALSSEGQLYTWGKATCLGHQLVERS---VQGCSVPRL 819

  Fly   192 STLLQHE---DPMVSDGALKCFASVADRFTRKW-------VDPAPL-AEYGLTTELLKRLQSV-- 243
            .:.|||:   |..||  ...|.|..:......|       :.||.: :|..|.|.:|..|.:.  
  Fly   820 VSSLQHKRIVDVAVS--VAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPA 882

  Fly   244 -GGNTHSSLTAAGTQ------------------PT-----------SSSQPAATTNSDAINENVA 278
             |....|:.:...||                  ||           ||.....|.|.:  :|.:|
  Fly   883 SGIACTSAQSLVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQLLGMCSSQDNRQTPNQE--SECIA 945

  Fly   279 GT----------ATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRSQLADALER 333
            ..          |.|:|..:.:....|:..:.:.:..:.:..|..||     .:||: :..|.::
  Fly   946 VACLNLFRLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGS-----QVLRT-IQVAAQQ 1004

  Fly   334 ALQGDERCVLD--CMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTHRQLIDC 396
            |||.....:|.  ..|...|..||..|..||.:.|                       ||.:.|.
  Fly  1005 ALQDGWSVLLPTAAERAQTLTSLLPSEPGQASSAG-----------------------HRFMTDL 1046

  Fly   397 IRSK------DSEALREAI--ESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQ 453
            :.|.      ...||:.||  ||.....:|.|.|...|         |:::..|....|.:::.:
  Fly  1047 LVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHLPL---------LQLITRLLSNNAALSQTR 1102

  Fly   454 RSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSP 518
            .|.:|                            ||.. :|..|..:..|:|.:.         ||
  Fly  1103 LSPTL----------------------------GKQQ-EKEEEEREQQHQEPST---------SP 1129

  Fly   519 DHSLLNKDGKKYTLMEPRGDPE--------MAPIYLKVLLP-------------IFCR----TFL 558
            ..|||::..:.......:..||        :...|:..|:|             :.||    ...
  Fly  1130 SLSLLHRFQRLLLSHIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSF 1194

  Fly   559 GSMLGSVRRA-----SLALIKK------IVQYAYPTVLQSL----------------------SE 590
            |.|:|.:.|.     |.||:.:      :::...|..|..|                      .|
  Fly  1195 GQMVGHLGRVLQADISDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGE 1259

  Fly   591 TSFSEDAA-----STSGQNGG-----------------NLLI----------------------E 611
            ....:|..     ...|..||                 |||:                      |
  Fly  1260 LRDGDDMGWPGIICRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESE 1324

  Fly   612 VIASVLDNEDDGDGHLIVLNIIEEIMCKTQEEFLDHFARLGVFAKVQALMDTDAEELYVQLPGT- 675
            .:.||||:   |.|..:...:..::.....|..|:|. :||.: .|||     :.|.....||. 
  Fly  1325 TLRSVLDS---GLGKDLTAEMSSQVHRTAMEHILEHH-KLGKY-MVQA-----STEEKSSAPGPS 1379

  Fly   676 -----VEEPAAAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHWREWSICRGRDCLYVWSDSVA 735
                 ..|.|.||...   :||....|...::.|:  ||           ||..|...:.|.  .
  Fly  1380 RLTHFSSECALAQLLG---LVANLMCSGPALQPAE--LQ-----------CRQLDKSSLLSG--G 1426

  Fly   736 LELSNGSNGWFRFIIDGKLATMYSSGSPEN--GNDSSE-------------NRGE---------F 776
            |:|...||.:     |.:.....||.|..:  ||..:|             .||:         |
  Fly  1427 LQLLQPSNPF-----DEEKGEARSSHSCHSTAGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAF 1486

  Fly   777 LEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQ---KTNQLQIHN---TEGHQVTVLQD 835
            :..|..||       ||:|  |.|:        |:..::   |.:.|..|.   || |.|..|:.
  Fly  1487 ISGLAEAR-------VSEP--PVAA--------WLALTERYCKAHNLMWHQEFATE-HPVQELER 1533

  Fly   836 DLPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSA 900
            .|...:.      :|.:....||               |..:||                     
  Fly  1534 LLSAVLI------RHQYLGGLVL---------------NALETE--------------------- 1556

  Fly   901 QIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSGLV 965
             :.|...:..:..:|.|.:.|........|.:::......|.:|..|::|  |..|......|| 
  Fly  1557 -VPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYE--VRPAISPQQRGL- 1617

  Fly   966 QALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQKL---- 1026
                                      :|:.:.::            .||.|.....|:|:|    
  Fly  1618 --------------------------RRLPILQR------------PPRFKMLVRRLLQELRSSR 1644

  Fly  1027 ----------VSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKME 1081
                      .|:.:..||.|             |.:.|:   .||..|.|.||.    |.|...
  Fly  1645 QPAKPEDLLNASIQQEQEKKP-------------QSMPKQ---ELEEQEEEETLL----RRLNER 1689

  Fly  1082 PLATIGQLSKYLLKMVA----KQWYDLD---RSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYI 1139
            .:...|:|...|::.:.    :...|::   |:.|..:::.:............ .:..|||   
  Fly  1690 QIHGEGELDPALMQDIVDFALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQL-LELHGLL--- 1750

  Fly  1140 GSNAKTCDWVNPAQYGL--------VQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFA 1196
                      :.|||.|        ::.|||.|.:...|....:|.:    ||..:...|.....
  Fly  1751 ----------DAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQ----LNMISAYQKARLLL 1801

  Fly  1197 IDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCA 1261
            ....|    ..:.:|..|     .|.|...||...|...|.|.|:|    |::....|.:.:   
  Fly  1802 AQSRV----LDWAVRELR-----RLVNQEQQGHARGKDSTNLGTYV----LLKRLPRARFLL--- 1850

  Fly  1262 TDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRE------- 1319
               ||:  .:..::.|.|..|   :|..||  :.|.|:|:....|     .|..|..:       
  Fly  1851 ---SVF--GLLAKELGPNELG---FLINSG--LLGTVLGLLAQTG-----GEGATGGQVHGELSI 1900

  Fly  1320 --------RRQIRAQL------KHMTTGARVIRGVDWRWEEQDG--CAEGTITGEI-HNGWIDVK 1367
                    ::..:|||      |.|..|.|::||.||:|.:|||  ..||.|..|: .:||:.|:
  Fly  1901 LYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVE 1965

  Fly  1368 WDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLP 1432
            |..|..||||||.||:|||:|||              ||...|.|:|              |...
  Fly  1966 WYTGATNSYRMGKEGQYDLQLAD--------------SALNVASPTE--------------PERE 2002

  Fly  1433 EATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKES 1497
            :.:....:|...|:.:....:.|.|                  :...||:.|........|....
  Fly  2003 DVSGSEASPTSDSHPSKLLRHCAAK------------------LLQILAVGTGLHGAQLDKDALR 2049

  Fly  1498 GTNQMHKDNISGPSPLSRELEH------ISDLSAINNSMPAINSSNVSDLAT---ISENLSLTEL 1553
            |...|.: .|..|.|....:.:      :..:.||:...|.:    ..:|:|   :|..|||.|.
  Fly  2050 GMTSMFR-TIIYPKPSMSNISYALGWLNLGFIRAISGDCPRL----CLELSTPGWLSHYLSLLEQ 2109

  Fly  1554 SKEN------------ICRVLTPSYKPAES-----------VTASQSSSHPDVQSSSPRENDIKN 1595
            ...|            :.:::...:...|.           .|..:.:.|      .|.:..:..
  Fly  2110 PAGNEAGVYRQLHCLRLLQLILAQWGAEEEPRMPALVHQLFATLGRIALH------CPGDASLLP 2168

  Fly  1596 ISNIEENNKMNANNSVNKISKDLLANL-RTSNIAGCPPV----------------------TQLS 1637
            .:..:....:.|::| ..::::|:|.| |...:....||                      |.|.
  Fly  2169 TAEGKARVLLTASHS-GSVAEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTALD 2232

  Fly  1638 TEALEMID----------KMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGG-------------- 1678
            :|.:.::.          :.|.|:......|:.::::.|....|...| ||              
  Fly  2233 SEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAP-GGVGSGVGFVKVQLPA 2296

  Fly  1679 ------------KKTPKAQALIN----------PDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQ 1721
                        .:.|..:.|:|          |:          ..|.|:.:..:..:.|..||
  Fly  2297 VMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPE----------LRELPSSADGRLDLALLRAQ 2351

  Fly  1722 Q---------------------------PNAVLSIVD-------------IKEQPISNENVSVPS 1746
            |                           |.::.:..|             .::|.:|:.:...| 
  Fly  2352 QLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQDQQLSSGSGQEP- 2415

  Fly  1747 QMSISVPNLTTTSASEVP---STSEVATHT-GLLETFAAIARRRTSQGTNIQDN----------- 1796
            |:.|....|..|.||.|.   |..::||.. ..:::.|..|.:..|:|..:..|           
  Fly  2416 QLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPT 2480

  Fly  1797 --------QIMNAEANVNEHGDQNAS-----------GSFLGHSVT-SLVKLALSS-NFHSGLLS 1840
                    .:...|...:|..:|.:.           |..:....| ..|:|||.. :..:.::.
  Fly  2481 MVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMP 2545

  Fly  1841 TAQ-------SYPSLSSNN-SENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDF 1897
            |.:       .:|.:.:|. .|:..|...|.:|...::.|......:.|.||:|:.|:.|..:..
  Fly  2546 TPEQIVQWILEHPDVCANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPM 2610

  Fly  1898 LESCRAPALLGDLDDEDDMDEDNDEEENED--------------------EYEEV-----GNTLL 1937
            ..|..||.:         ..|...:.:..|                    ::||:     |..|:
  Fly  2611 AVSGPAPPV---------KFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLI 2666

  Fly  1938 QVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDE-------FVLKRQFSALIPAFDPRP------- 1988
                       :|.|.:.:..|.|    .|.:.       ||......|......|||       
  Fly  2667 -----------VDTEGLHDLNVQV----DWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGA 2716

  Fly  1989 -----------------------GRTNVNQTSDLEISPLGAELP-KPQQSGGPETIE----QPLL 2025
                                   |.:.:...|.:....|..:.| :|...|....:|    ||..
  Fly  2717 RVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVSSVRSKQLTVDFPDQPAWQGHINEVELVASQPTS 2781

  Fly  2026 G-LKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELL-------------------------QCSQL 2064
            . |...|.....:|..::   ..||:  |.::.|.                         .|...
  Fly  2782 ATLPSLGDSCSQMPPSDL---IEDWS--RCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHW 2841

  Fly  2065 NKLDKFRKIWEPTYTIVYREVSP----------EAQESTCLES-EEFPQTPDVSSKSGAS--TLS 2116
            .:|:...:|...:.|:   :|||          |.:...|::| :|:...|   ..:|||  .|.
  Fly  2842 IRLELHDRILVHSLTL---KVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIP---VPAGASRVLLM 2900

  Fly  2117 PNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQ 2181
            ...|.:..:          .:|:....|.||:       ..|.||:.      |:.::....||.
  Fly  2901 QQVPTYYPW----------VEVVVKQCQNNGI-------QCKIHGIK------FVGRRQQPDLQH 2942

  Fly  2182 QIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIP 2246
            .:.:...|||           :....:.|..|           |....|....:.......|.:|
  Fly  2943 ILANAQFLAS-----------EYSAGVGPGST-----------AGAGAVSTSHEEAAAAPEQDLP 2985

  Fly  2247 --IMSPRRDDHEFRIGRLKHERVKVP 2270
              :|....:|.| ::|.||..:||||
  Fly  2986 CTVMVWGLNDKE-QLGGLKGSKVKVP 3010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786 9/34 (26%)
ANK 396..509 CDD:238125 22/120 (18%)
ANK repeat 422..453 CDD:293786 5/30 (17%)
ANK repeat 455..484 CDD:293786 2/28 (7%)
F5_F8_type_C 1173..1298 CDD:329041 27/124 (22%)
MIB_HERC2 1333..1389 CDD:310955 30/58 (52%)
DamX 1576..>1725 CDD:330571 32/244 (13%)
HECTc 2265..2725 CDD:238033 4/6 (67%)
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826 9/37 (24%)
RCC1 740..787 CDD:278826 14/52 (27%)
RCC1 790..841 CDD:278826 15/55 (27%)
RCC1_2 828..857 CDD:290274 6/30 (20%)
Cyt-b5 1290..1363 CDD:278597 15/76 (20%)
MIB_HERC2 1928..1987 CDD:284184 30/58 (52%)
UBA_HERC2 2515..2559 CDD:270585 7/43 (16%)
Cul7 2624..2699 CDD:288381 12/89 (13%)
APC10-HERC2 2762..2932 CDD:176485 36/203 (18%)
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446991
Domainoid 1 1.000 69 1.000 Domainoid score I6289
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.830

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