DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and HUWE1

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster


Alignment Length:2770 Identity:502/2770 - (18%)
Similarity:856/2770 - (30%) Gaps:973/2770 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 QNCVESLSTLLQHEDPMVSDGALKCFASVADRFTRKWVDPAPL------------AEYGLTTELL 237
            |.||    .:..|::| ..:..::.|...|..:   |::.|.|            |.:.|...|:
  Fly  3122 QYCV----CMPTHQNP-TEETQMETFTQDALHW---WLEEATLLDMESQTDACLYAAHFLLPHLI 3178

  Fly   238 KRLQSVGGNTHSSLTA-AGTQPTSSSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSI 301
            |.|::..........| ..|.|.|.|..:||::|   ..:|.|||..:.::.:.|...|.:..:.
  Fly  3179 KELKAAHQQRKQEEAARQSTTPASGSNASATSSS---TTSVVGTAAPTATSSIASGLLANAVSAG 3240

  Fly   302 STTISLLSTLCRGSPSITHDILRSQLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRG 366
            |.:.||:  :...:.|.|....||.:...:...|                       |..:.:..
  Fly  3241 SGSSSLV--VPPVAASATGGTRRSSIPVLISSTL-----------------------GPSSASSA 3280

  Fly   367 SNNPNQGQLAPR------PRRNNTNTDRTHRQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQT 425
            ::....|..:..      |.||.::.|..       :.|:.....|...:.||:           
  Fly  3281 TSATGNGATSDATTTTGGPTRNFSSVDSN-------VSSETQTTTRPPRQRGGL----------- 3327

  Fly   426 LLNWASAFGTLEMVEYLCEKGADVNKGQRSSSLHYAACFGRPAIAKILLKFGAYPDL-----RDE 485
                                      .|:|.                 |.|..|.::     :|.
  Fly  3328 --------------------------RQQSQ-----------------LPFNIYAEIDLTNEQDS 3349

  Fly   486 DGK--------TPLDKARERLDDGHREVAAILQSPGEWMSPDHSLLNKDG---KKYTLMEPRGDP 539
            :|.        |..|.|..:........||.:..|.....|...||...|   :.:|.::   :.
  Fly  3350 EGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLD---ET 3411

  Fly   540 EMAPIYLKVLLPIFCRTFLGSMLG------SVRRASLALIKKIVQYAYPTVLQSLSETSFSEDAA 598
            |:      :||.:..|.....:.|      |.|.:..|||........|..||.....:.|....
  Fly  3412 EL------LLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPR 3470

  Fly   599 STSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIEEIMCKTQEEFLDHFARLGVFAKVQALMDT 663
            .::.:.....|:.:...:      .:..|..||:....:.:|...|           .:.:.::.
  Fly  3471 PSANRTPAPTLVSMPTPM------SNAALEQLNVTAPDVVRTDRNF-----------ALPSSLEV 3518

  Fly   664 DAEELYVQLPGTVEEP-AAAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHW---------REW 718
            |.:    .|||.|:.| ..||.....:::.|.|  ..|..|...::..:...|         ||.
  Fly  3519 DVD----VLPGIVDLPQQEAQPEDDQLLLPPPP--PPPPSDTTPLVHAEDDLWPGTVVSAGTREE 3577

  Fly   719 SICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSENRGEFLEKLMRA 783
            |.          :.:||.|.:...|               .|..||...:|||:..         
  Fly  3578 SS----------APAVATESTEAVN---------------ESNQPEPTPESSESTS--------- 3608

  Fly   784 RSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDDLPGFIFESNRGT 848
                     ..|..|:|                            :.|.|:   ||...:::.|.
  Fly  3609 ---------PNPQAPSA----------------------------EPTPLE---PGAAVDASVGA 3633

  Fly   849 KHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQIIPRGAVAILTD 913
            :...:.|.......||| :||              .:.::|.|:            |.|:..| :
  Fly  3634 QTPATTEEAASTAGASG-TTA--------------TITDMSPEV------------RAALGDL-E 3670

  Fly   914 IVKQIELSFEEQHMA--PNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSGLVQA---LVAVLS 973
            :.:.::.||    :|  |:...|..:.:.|.  .|.|.:....:|.::....||:.   .:|.|.
  Fly  3671 VPEGVDPSF----LAALPSEMREEVIQEHLR--MQRIRQRAQQNAIQIAHDSLVEVNPEFLAALP 3729

  Fly   974 VNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESAT---NKPRTKSTASILIQKLVSVLESTE- 1034
            :|   ..|....:.::::||.:. :....||.|::|.   |.|..      |.|.:::.:|.:: 
  Fly  3730 LN---IQSEVLMQQRIEQQRQAA-QTANPEDPVDTAAFFQNLPEN------LRQAILTDMEESQI 3784

  Fly  1035 -KLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVA 1098
             .||      |......|.|         |.:.||    |:|..:...|.:  ..||::...:.:
  Fly  3785 ASLP------PELAAEAQFL---------RRDWES----RNGARMDAHPPS--NALSRFQTTLQS 3828

  Fly  1099 KQ--------WYDLDRSTYFYLKKIREHRTATVFTHSFD----------------FDEEG----- 1134
            ..        |||...:..      .:|...|...|...                .::|.     
  Fly  3829 LDDTRWHSSIWYDASGNAQ------PQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDP 3887

  Fly  1135 ------LLFYIGSNAK------------------TCDWVNPAQYGLVQVTSSEGKTLPYGKLEDI 1175
                  |||....:.|                  |.||:..|...::|.|               
  Fly  3888 DSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKT--------------- 3937

  Fly  1176 LSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSA-LRNWLLQGSKDGSTWTTLS 1239
             :.|:.:........|..|..:.:..           |.||..:. |.|.|.:||.         
  Fly  3938 -NEDNANFGAGQAGGKPEWLKLRVDA-----------AFGYKSNIFLINRLYEGSA--------- 3981

  Fly  1240 THVDDKSL-VEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVAD 1303
                 :|: :.|.:......||.....|..:|..                 |.|..:.|      
  Fly  3982 -----RSISINPQAAQMIVRNCLDLLFVLAKHYP-----------------SSFVPFNR------ 4018

  Fly  1304 DIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKW 1368
                     :.|.|                 |::..|........|...|..:|...:|      
  Fly  4019 ---------DVKAR-----------------RILSAVFGMPSPTAGSGGGAGSGSAASG------ 4051

  Fly  1369 DHGVRNSYRMGAEGKYDLKLADCEY------LSAFDGNQSMGSASTAAKPS---EKGGNTLTSRK 1424
              |:.....:...|..|.:...|.|      .|.||.:       .|.|||   ::..:|..:..
  Fly  4052 --GLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDH-------PAPKPSVPLDEAPSTSKAAA 4107

  Fly  1425 SSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSRE 1489
            :.:..:...:|..:||......|| :|.|. |     .:..|:  ..:||:....:|....:|:.
  Fly  4108 AKAAATAKVSTAGSQNKHSVPYQT-NAKNF-W-----DVVLNI--DQQTQVRLANVAQFPLTSQP 4163

  Fly  1490 ARAKHKESGTNQMHKDNIS-GPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTEL 1553
            |......:.      |.:| ..||..:.||.: ....|..| |.:....|..||::|     |||
  Fly  4164 AWEWQPNTA------DFLSFSESPFGQLLEML-PYKVICRS-PHLTDMLVKLLASLS-----TEL 4215

  Fly  1554 SKENICRVLTPSYK------PAESVTASQSSSHPDVQSSSPREN-----DIKN--ISNIEENNKM 1605
            .||.....|:....      |.:...|:.:::||. ....|.||     :|.:  .:||||....
  Fly  4216 PKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPP-PPQPPAENTATATEIGDGLAANIEEQASP 4279

  Fly  1606 NANNSVNKISKDLLANLRTSNIAGCPPVT----------------QLSTEALEMIDKMRDGVD-- 1652
            .:.|..:..|.......:...::...|||                ||..|.|.......:|:|  
  Fly  4280 ASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNV 4344

  Fly  1653 --MIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQAL------INPDNANQKQIIVTSEEFPTKS 1709
              :|.|::....::....:......:.|......||:      |...|.:|.....||:...|..
  Fly  4345 AKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSG 4409

  Fly  1710 SKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVP-NLTTTSASEVPSTSEVATHT 1773
            :...:.:..|.....::|..:.:.|..:.:...:  ..:.||.| |...|...::||..::.:::
  Fly  4410 AAAATASYVPTVSGASLLPNLAVHEGIMQDRFTA--EHVIISAPKNAKPTCELQLPSMKKLMSNS 4472

  Fly  1774 G-------LLETFAAI-----ARRRTSQGTNI------QDNQIMNAEANVNEHGDQNASGSFLGH 1820
            .       .|:.|..:     |:...|.|..:      .|:.|::.|      ||..|||     
  Fly  4473 SAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIE------GDGGASG----- 4526

  Fly  1821 SVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTST 1885
                                          .:|.::||.          |||||:....|     
  Fly  4527 ------------------------------GSSSDMAPG----------SASTISPPPPM----- 4546

  Fly  1886 SSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGN------------TLLQ 1938
              ::.|::                 .|.||.:||:||..:   :..|||            ||.|
  Fly  4547 --ETNQIA-----------------QDGDDDEEDDDEARS---FPGVGNHAVASASKSTKPTLSQ 4589

  Fly  1939 VM---VSRNLLTFMDDEAMENRLVGVTKRKSWDDEF---VLKRQFSALIPAFDPRPGRTNVNQTS 1997
            ::   |..|.|:        ..||.:.:.|   |||   ||:....|.........|.:..:..|
  Fly  4590 ILCLDVLWNTLS--------ECLVALEESK---DEFAVLVLQPTVEAFFLIHASHRGASKKSGRS 4643

  Fly  1998 DLEISPLGAELPKPQQSGGPETIEQPLLGLK-LRGPG-IGGIPEVEIDLSNTDWTIFRAVQELLQ 2060
            .:           |..:|         .||: ..|.| |||:                       
  Fly  4644 FM-----------PNAAG---------FGLRAAAGAGAIGGL----------------------- 4665

  Fly  2061 CSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGF 2125
                                  ...:|.|||.:       |...||||.:     :|:|      
  Fly  4666 ----------------------GAAAPSAQEYS-------PFMDDVSSAN-----TPSS------ 4690

  Fly  2126 NVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSV----LSED----LFISKKITNKLQQQ 2182
                   .|.||  |...|....|...:.:......:|.    |.:|    |..::|....|.|.
  Fly  4691 -------ASFDD--EPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQI 4746

  Fly  2183 I-QDPLVLASNALPNWCENLNQSCPF--------LFPFETRQLYFNCTSFGASRSIVCLQSQRDV 2238
            : |.|..|:..             ||        :..|:.::.||..........|    .:.:.
  Fly  4747 LRQSPTHLSDG-------------PFAVLVDHTRILDFDVKRKYFQTELERLDEGI----RREEH 4794

  Fly  2239 TVERQRIPIMSPRRDDHEFRI-GRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEG 2302
            ||..:|:.:.     :..||: .||..|.           |           |:...:.|.||||
  Fly  4795 TVSVRRVTVF-----EDSFRVLYRLGPEE-----------W-----------KNRFYIVFEDEEG 4832

  Fly  2303 TGLGPTL-EFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAP 2366
            ...|..| |:|.:::.||......::..              :.|:.  |.|.:|...|.     
  Fly  4833 QDAGGLLREWYVIISREIFNPMYALFCV--------------SPGDR--VTYMINPSSHA----- 4876

  Fly  2367 LPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGD 2431
                   ..|.|.||.|.|..:||.:.|.:|::...:.||.:.:...:|...:::          
  Fly  4877 -------NPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDME---------- 4924

  Fly  2432 LSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDD 2496
                |:|.:..:....|::.|.:                                    ::.::.
  Fly  4925 ----SQDYEFYKGLDYLMKNDIS------------------------------------TLGYEL 4949

  Fly  2497 TISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQ-AELLPNGSSVNVTIDNLE 2560
            |.|.|.:.                                 :|.|| .:|.|||....||.:|..
  Fly  4950 TFSTEVQE---------------------------------FGVTQIRDLKPNGRDTAVTEENKF 4981

  Fly  2561 AYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTE 2625
            .|.:|:....:...|.||:.||.:||.::.|...::.|...|..::|.|  .|....||:.:.||
  Fly  4982 EYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISG--LPDIDIEDLKANTE 5044

  Fly  2626 PKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTV----VRKVDAG 2686
            .. .|...|...|.|...|.|....:|..||||.||.|.:|..|..:|.....:    :.:.|..
  Fly  5045 YH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRS 5108

  Fly  2687 VGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE--KGF 2724
            ....|..:||.:.|.||.|.:.:.::..||.|..|  :||
  Fly  5109 TDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786 4/26 (15%)
ANK 396..509 CDD:238125 16/125 (13%)
ANK repeat 422..453 CDD:293786 0/30 (0%)
ANK repeat 455..484 CDD:293786 4/33 (12%)
F5_F8_type_C 1173..1298 CDD:329041 19/126 (15%)
MIB_HERC2 1333..1389 CDD:310955 9/55 (16%)
DamX 1576..>1725 CDD:330571 33/181 (18%)
HECTc 2265..2725 CDD:238033 99/468 (21%)
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 25/150 (17%)
DUF4414 3675..3779 CDD:291075 25/119 (21%)
HECTc 4796..5149 CDD:238033 105/494 (21%)
HECTc 4820..5148 CDD:214523 95/441 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446985
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.830

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