DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Trip12

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_038939619.1	Gene:	Trip12 / 316575	RGDID:	1306607	Length:	2074	Species:	Rattus norvegicus

Alignment Length:	2359	Identity:	542/2359 - (22%)
Similarity:	858/2359 - (36%)	Gaps:	744/2359 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   767 NDSSE-NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQV 830
            |.:|| :||...::...:.|.||   |.||..|..:.        ..:.|||.|:...
  Rat    62 NTTSELSRGHLSKRSCSSSSAVI---VPQPEDPDRAN--------TSERQKTGQVPKK------- 108

  Fly   831 TVLQDDLPGFIFESNRGTKHTFSAETVLGPDF--ASGWSTAKKKR-----------NKSKTEGQK 882
                        :::||.|.:.|      ||:  .:..|:|||.|           ||..::.:|
  Rat   109 ------------DNSRGVKRSAS------PDYNRTNSPSSAKKPRAFQHIESLSETNKPPSKSKK 155

  Fly   883 FQVRNLSREIYNKYFKSAQI-----------------------------IPRGAVAILTDI---- 914
               |:|.:|   :..||||:                             :..|:.:..|..
  Rat   156 ---RHLDQE---QQLKSAQLPSTSKAHTRKSVAAGSSRSQKRKRTESSCVKSGSGSESTGAEERS 214

  Fly   915 VKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSG--LVQALVAVLSVNHW 977
            .|..:|:.:....|..|.  :|:||:....|.......|.||.....:|  :.|......:....
  Rat   215 AKPTKLASKSATSAKAGC--STITDSSSAASTSSSSSAVASASSTVPAGARVKQGKDQNKARRSR 277

  Fly   978 ETNSPRCKRNKMQKQ------------------RVSVFK-KCILEDNVESATNKPRTKSTASILI 1023
            ..:||..:|:..:|:                  :||:.| |..|..:.:|.|:||    ..|.|.
  Rat   278 SASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKP----GPSGLQ 338

  Fly  1024 QKLVSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQ 1088
            .||.|:.:||:|..    :||..  .|..|::..| :.....|.||  .|.|..|.....|
  Rat   339 AKLASLRKSTKKRS----ESPPA--ELPSLRRSTR-QKTTGSCAST--SRRGSGLGKRGAA---- 390

  Fly  1089 LSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTCD------ 1147
                                    :..|:.:.|         |.||....:.|:|...|
  Rat   391 ------------------------EARRQEKMA---------DPEGNQETVNSSAARTDEAPQGA 422

  Fly  1148 WVNPAQYGLVQVTS---SEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYT 1209
            ..:.:..|.|.:|:   ||......|:|:.:|  ::..|..|.       |. .||    |....
  Rat   423 AASSSVAGAVGMTTSGESESDDSEMGRLQALL--EARGLPPHL-------FG-PLG----PRMSQ 473

  Fly  1210 LRHAR-GYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTAT---WPINCATDDSVWYRH 1270
            |.|.. |.|.|:....||||.:.......|...::...|:..|:..|   :|:.     ||....
  Rat   474 LFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVK-----SVVPAL 533

  Fly  1271 IRIQQNGRNASGQTH------YLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKH 1329
            |.:.|...|.....|      |:    .|...|...|..|                 .|...|:.
  Rat   534 ITLLQMEHNFDIMNHACRALTYM----MEALPRSSAVVVD-----------------AIPVFLEK 577

  Fly  1330 MTTGARVIRGVDWRWEEQDGCAEGTIT-----GEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLA 1389
            :    :||:.:|        .||..:|     ...|:..|             :.|.|     ||
  Rat   578 L----QVIQCID--------VAEQALTALEMLSRRHSKAI-------------LQAGG-----LA 612

  Fly  1390 DC-EYLSAFDGNQSMGSASTAAK------PSE-----KGGNTLTSRKSSSTPSLPEAT------- 1435
            || .||..|..|....:.:.||.      |.|     .....||.|.:.......|:|
  Rat   613 DCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARL 677

  Fly  1436 -EKNQNPEGASNQTVSADNLA---------------------------------------WKQTV 1460
             :..|:.|....|..|.|.|.                                       .||:.
  Rat   678 VDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQSF 742

  Fly  1461 ETIAENVF--------ASAKTQI-------------------------------ISNQL----AM 1482
            ..|||.:.        .|.:.||                               :...|    |.
  Rat   743 TDIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQ 807

  Fly  1483 NTSSS----REAR----------AKHKESGTNQMHKDNISGPSPLSR-------ELEHISD---- 1522
            ||..:    |:.|          ::..|...:|:.:|.|| .|.|.|       .::.|::
  Rat   808 NTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQVGEDEIS-LSTLGRVYTIDFNSMQQINEDTGT 871

  Fly  1523 LSAIN---NSMPAINSSNVSDLATISENLSL----TELSKENICRVLTPSYKPAESVTASQSSSH 1580
            ..||.   |.:...|:|..|||........|    .||:|..|..:....|:      ...||:.
  Rat   872 ARAIQRKPNPLANTNTSGYSDLKKDDARAQLMKEDPELAKSFIKTLFGVLYE------VYSSSAG 930

  Fly  1581 PDVQSSSPRE-------NDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLST 1638
            |.|:....|.       .|.:.:.::.:|:.::::.:....|:||      ..:.|...:.::..
  Rat   931 PAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDL------KIVVGALQMAEILM 989

  Fly  1639 EALEMIDKM---RDGV-DMIRNM--SNSILSTDTFPVPCTNVPVG----GKKTP----KAQALIN 1689
            :.|..|..:   |:|| ..::::  |.|:|::.  |..|||   |    |..||    .|.|..|
  Rat   990 QKLPDIFSVYFRREGVMHQVKHLAESESLLTSP--PKACTN---GSGSLGSTTPASSGTATAATN 1049

  Fly  1690 PDNANQKQIIVTSEEFPTKS---SKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVP---SQM 1748
                       .|.:..:.|   |:..|:.|.|..:.:.||....:.::.......|.|   .::
  Rat  1050 -----------ASADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKV 1103

  Fly  1749 SISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNA 1813
            .....:.|||.:   |.:|.:|:                   .|.:....::|::|.|.......
  Rat  1104 DNQAKSPTTTQS---PKSSFLAS-------------------LNPKTWGRLSAQSNSNNIEPART 1146

  Fly  1814 SGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSN--------------------NSENIAP 1858
            :|.                   || |:.|.|..::|:|                    :|||:..
  Rat  1147 AGV-------------------SG-LARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDG 1191

  Fly  1859 SNP------------------------------SNTSAGQQSASTINHT-----LTMSLTSTSSD 1888
            |||                              |..|....|:..|.|:     |.:.|||.|..
  Rat  1192 SNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEK 1256

  Fly  1889 ---SEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSR--NLLTF 1948
               |.::.|:.||....:..|.|              ||.....|.||:..|..:|.:  |.|:.
  Rat  1257 DAVSREIRLKRFLHVFFSSPLPG--------------EEPVGRVEPVGHAPLLALVHKMNNCLSQ 1307

  Fly  1949 MDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDP---------RPGRTNVNQ--TSDLEIS 2002
            |  |....::............|.|.|...|| ..|:.         .|...||.|  ...::|.
  Rat  1308 M--EQFPVKVHDFPSGNGSGGSFSLNRGSQAL-KFFNTHQLKCQLQRHPDCANVKQWKGGPVKID 1369

  Fly  2003 PL------------------GAELPKPQQS---GGPETIEQPLLGLKLRGPGIGGIPEVEI--DL 2044
            ||                  |......:.|   |..|.|::.|....|....:....:..|  .|
  Rat  1370 PLALVQAIERYLVVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHL 1434

  Fly  2045 SNTDWTIFRAVQEL-LQC--------SQLNKLDKFRKIWEPTYTIVYREVSPEAQES-TCLESEE 2099
            ...:.|:::||::. :|.        .:.|.|.: ..||..|:||.|:.|..:.:.| .|:..:.
  Rat  1435 LPYNMTVYQAVRQFSVQAEDERESTDDESNPLGR-AGIWTKTHTIWYKPVREDEESSKDCVGGKR 1498

  Fly  2100 -FPQT-PDVSSKSGAST--------------------LSPNSPMHIGFNVADNNLCSVDDVLELL 2142
             ..|| |..:|...|..                    |.|..|.:|.|.  |.:|    ||:.||
  Rat  1499 GRAQTAPTKTSPRNAKKHDELWHDGVCPSVANPLEVYLIPTPPENITFE--DPSL----DVILLL 1557

  Fly  2143 TQINGLNQSEI----DSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQ 2203
            ..::.:::...    ::..||    ::....||:.|:|.|..:|:|||||:.:..:|.|...|.:
  Rat  1558 RVLHAISRYWYYLYDNAMCKE----IIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGK 1618

  Fly  2204 SCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSP---RRDDHEFRIG-RLKH 2264
            :|||.|||:|||:.|..|:|...|::             ||:...:|   :.|..:.|:. ||..
  Rat  1619 TCPFFFPFDTRQMLFYVTAFDRDRAM-------------QRLLDTNPEINQSDSQDSRVAPRLDR 1670

  Fly  2265 ERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLC 2329
            ::..|.| |:||..|..||:...:.:::||:::.:|.||||||||||||||:.|:||:||.:|
  Rat  1671 KKRTVNR-EELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLW-- 1732

  Fly  2330 DDDLGEDT--ENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSE---ICENVLKYFWFFGVFVA 2389
               .||:.  .|...|.||..     |:...: |:|..|..:.::   |.:..:| |.|.|..:|
  Rat  1733 ---RGEEVTLSNPKGSQEGTK-----YIQNLQ-GLFALPFGRTAKPAHIAKVKMK-FRFLGKLMA 1787

  Fly  2390 KVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSN 2454
            |.:.|.||||:||...|.:.                                      :||.:::
  Rat  1788 KAIMDFRLVDLPLGLPFYKW--------------------------------------MLRQETS 1814

  Fly  2455 KSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLE 2519
                    |:..:|.:|||...:.:..:::::.:|:.:|.|   .::.|..|...|:..|.||
  Rat  1815 --------LTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQD---KSQTKESLQYALETLTMNG-- 1866

  Fly  2520 VSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSD 2584
            .|:|||.|.|| ||     |:...||...|..:.|||.|||.|..|::.:.|.:|:.:|..:|.|
  Rat  1867 CSVEDLGLDFT-LP-----GFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRD 1925

  Fly  2585 GFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSG 2649
            ||..||||..|..|.|.|...::||.:...|..:.::....|..||..||...:....:|.|...
  Rat  1926 GFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1990

  Fly  2650 DERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGS----YPSVNTCVHYLKLPDYPTEEI 2710
            ::::.||||.||...||.||..:|:|.||:|||......:    .|||.|||:|||||||.:.||
  Rat  1991 EQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEI 2055

  Fly  2711 MKERLLTATKE--KGFHLN 2727
            |:::||.|.:|  :.|||:
  Rat  2056 MRDKLLIAAREGQQSFHLS 2074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	29/134 (22%)
		MIB_HERC2	1333..1389	CDD:310955	10/60 (17%)
		DamX	1576..>1725	CDD:330571	36/172 (21%)
		HECTc	2265..2725	CDD:238033	155/470 (33%)
Trip12	XP_038939619.1	SRP1	489..>714	CDD:227396	55/280 (20%)
		WWE	814..876	CDD:397111	12/62 (19%)
		HECTc	1672..2072	CDD:238033	155/469 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820