DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and Hecw2

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_001101688.1 Gene:Hecw2 / 316395 RGDID:1593244 Length:1578 Species:Rattus norvegicus


Alignment Length:1990 Identity:372/1990 - (18%)
Similarity:625/1990 - (31%) Gaps:790/1990 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1061 LERAECESTLF---DRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTAT 1122
            |:||..::.|.   .||..|..|... |:||....::....|:  ::|.|.:..|..|.|:..| 
  Rat    43 LQRANSDTDLVTSESRSSLTASMYEY-TLGQAQNLIIFWDIKE--EVDPSDWIGLYHIDENSPA- 103

  Fly  1123 VFTHSFDFDEEGLLFYIGSNAKTCDW-VNPAQY-----------------GLVQVTS-------- 1161
               :.:|....|:   .|:......| :.|..|                 |.::.|:        
  Rat   104 ---NFWDSKNRGV---TGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNP 162

  Fly  1162 -----SEG-KTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSA 1220
                 :|| :....|.|.   ||..:|.   |..:.:| ..:..|::..|..|.           
  Rat   163 AVMMGAEGMEGCASGSLH---SRKLVSF---TLSDLRA-VGLKKGMFFNPDPYL----------- 209

  Fly  1221 LRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCA-------------TDDSVWYRHIR 1272
                                    |..::||..:::| .||             |.:.:|:|   
  Rat   210 ------------------------KMSIQPGKKSSFP-TCAHHGQERRSTIISNTTNPIWHR--- 246

  Fly  1273 IQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTR-----------------RER 1320
                                |.|.....:.|.:...:|:..||:|                 .||
  Rat   247 --------------------EKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLER 291

  Fly  1321 RQIRAQLKHMTTGARV----IRG-VDWRWE-----EQDGCAE--GTITGEIH------------- 1360
            :.:..|:.....|.|:    :.| :.:|.|     ::|...|  |||.| :|             
  Rat   292 QAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPSSAQEDASPEAVGTILG-VHTVNGDLGSPSDDE 355

  Fly  1361 -------------NGWI--DVKWDHGVRNSYRMGA-------------------EGKYDLKLADC 1391
                         ||.:  |...|...::|:|..:                   .|:.| .|.| 
  Rat   356 DMPGSHHDSTICANGPVSEDSVADGTPKHSFRTSSTLEIDTEDLISTSSRNSPPRGRQD-SLND- 418

  Fly  1392 EYLSAFD--GNQSMGSASTAAKP------------------------------------------ 1412
             ||.|.:  |....|:||::.:|                                          
  Rat   419 -YLDAIEHNGPSRPGTASSSERPMGASPKLRSSFPTDTRLNAMLHIDSDEEDHDFQQDLGYPSSL 482

  Fly  1413 SEKGGNTLTSRKSS------STPSLPEATEKNQNPEGASNQTVS----ADNLAWKQTVE------ 1461
            .|:||..:.||.|.      ::.:.||.....:|.:.:.::|.|    .:||   ..||      
  Rat   483 EEEGGLIMCSRTSRIDDGSLTSQTKPEDDNPVENEDASVHETASLEERPENL---PEVEDGSLPS 544

  Fly  1462 -TIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSA 1525
             |..:...||.:.|..::|.:....||:|  .....|||:....|...|....:.|.|.:.    
  Rat   545 GTAPDENEASVEPQPSADQGSTELCSSQE--VDQPTSGTDAGASDTSVGSRRAASETESLD---- 603

  Fly  1526 INNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQSSSPRE 1590
             ..|.|    |.||         |.||           || .||.:.:.|::|:.|:      .|
  Rat   604 -QGSEP----SQVS---------SETE-----------PS-DPARTESVSEASTRPE------GE 636

  Fly  1591 NDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIR 1655
            :|:       |....:.|.||                     .||||:.....            
  Rat   637 SDL-------EGADSSCNESV---------------------TTQLSSVETRC------------ 661

  Fly  1656 NMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPA 1720
                |.|.:..||           :||...:....|.|...:        ||.|.        |.
  Rat   662 ----SSLESARFP-----------ETPAFSSQEEEDGACAAE--------PTSSG--------PT 695

  Fly  1721 QQPNAVLSIVDIKEQPISNENVSVPSQM-SISVPN-------LTTTSASEVPSTSEVATHTGLLE 1777
            :.               |.|:|..|..: ::.||:       ...|:.||.....||....|.||
  Rat   696 EG---------------SQESVCTPGSLPAVQVPSREEEGSGAEATALSEQGELGEVWQRRGSLE 745

  Fly  1778 TFAAIARRRTSQGTNIQ--------DNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNF 1834
            ..||.|   |:..|:.|        |.|.....|...|.|....|                .:|.
  Rat   746 GAAAAA---TAAATDSQPQEDGDPGDTQGACEGATAQEEGATGGS----------------QTNG 791

  Fly  1835 HSGLLSTAQSYPSLSSNNS--ENIAPSNPSNTSAGQQS------ASTINHTLTMS---------- 1881
            |..|    :|.||:..:.|  :.:..:.|.|..|...|      ...:|.|.|..          
  Rat   792 HQPL----RSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQV 852

  Fly  1882 LTSTSSDSEQVSLEDFLESCRAPALLGDLDDE-----DDMDEDNDEEENEDEYEEVGNTLLQVMV 1941
            |..::|..:...|....:|.|. .:..:..:|     |...|:.|..:...::..  ..:|....
  Rat   853 LQRSNSIQQMEQLNRRYQSIRR-TMTNERPEENTSAIDGAGEEADFHQASADFRR--ENVLPHST 914

  Fly  1942 SRNLLT-----------------------------FMDDEAMENRLVGVTKRKSWDDEFVLKRQF 1977
            ||:.||                             |.::..:::.:..|.:.....:.:...|..
  Rat   915 SRSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDL 979

  Fly  1978 SALIPAF----------------------------------DPRPGRTNVNQTSDL--------E 2000
            ...:..|                                  |||....:...||.|        :
  Rat   980 VGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQ 1044

  Fly  2001 ISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFR-AVQELLQCSQL 2064
            .|....|:.:..:..||..:.:|                     ::|..|:.| ..|:::..:..
  Rat  1045 RSHSAGEVGEDSRHAGPPVLPRP---------------------ASTFNTVSRPQYQDMVPVAYN 1088

  Fly  2065 NKLDKFRKIWEPTYTIVYREVSPE-AQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVA 2128
            :|:..|.:  :|....:.:|..|: |:..:..|..:|.:|   ....|...||.::         
  Rat  1089 DKIVAFLR--QPNILEILQERQPDLARNHSLREKIQFIRT---EGTPGLVRLSSDA--------- 1139

  Fly  2129 DNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNA 2193
                    |::.||:    |.:.||.|.|..|.:                              .
  Rat  1140 --------DLVMLLS----LFEEEIMSYVPPHAL------------------------------L 1162

  Fly  2194 LPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFR 2258
            .|::|::...|     |..:.|     .|.|..|:             ..|.|  :|.:.|.|.:
  Rat  1163 HPSYCQSPRGS-----PVSSPQ-----NSPGTQRA-------------NARAP--APYKRDFEAK 1202

  Fly  2259 I----------------GRLKHERVKVPRNEDLLMWAMQVMKTHCNR---KSVLEVEFLDEEGTG 2304
            :                |:||    .:.|.:.||..|...:..:..:   ::.|.|.|:.|||..
  Rat  1203 LRNFYRKLETKGYGQGPGKLK----LIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLD 1263

  Fly  2305 L-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLP 2368
            . ||:.||:.||:.|:.....       .|.|.:.|.|.:.:  ..|:..:|             
  Rat  1264 YSGPSREFFFLVSRELFNPYY-------GLFEYSANDTYTVQ--ISPMSAFV------------- 1306

  Fly  2369 QNSEICENVLKYFWFFGVFVAKVLQDMRLVDI----PLSTSFLQLLCHNKVLSRNLQKVISDRRN 2429
                  :|..::|.|.|..:...|....|:|.    |...:.|::||                  
  Rat  1307 ------DNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILC------------------ 1347

  Fly  2430 GDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEF 2494
             |||                                 :|:.:|...:|.||.|:           
  Rat  1348 -DLS---------------------------------DLEYLDEEFHQSLQWMK----------- 1367

  Fly  2495 DDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDN 2558
            |:.|     |::::                  ||||.  :..::| .|:.||.|.|:::.||..|
  Rat  1368 DNDI-----HDILD------------------LTFTV--NEEVFGQITERELKPGGANIPVTEKN 1407

  Fly  2559 LEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGE---QFPHWSREDI 2620
            .:.|.|.::.:.::.|:.||.::...||.||...:.::.|...|..::|.|.   ....|...  
  Rat  1408 KKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNN-- 1470

  Fly  2621 ISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLH----PRLTVVR 2681
               ||.:.||:.:....:.|...:...:.::|...|||.||.||:|..|.|:|.    ||...|.
  Rat  1471 ---TEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVE 1532

  Fly  2682 KVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE 2721
            |. ..:.:.|..:||.:.|.||.||:..::.|:||||.:|
  Rat  1533 KW-GKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 19/137 (14%)
MIB_HERC2 1333..1389 CDD:310955 20/114 (18%)
DamX 1576..>1725 CDD:330571 24/148 (16%)
HECTc 2265..2725 CDD:238033 108/473 (23%)
Hecw2NP_001101688.1 HECW_N 45..162 CDD:406866 25/126 (20%)
C2_NEDL1-like 185..321 CDD:176073 29/198 (15%)
MDN1 <396..741 CDD:227596 90/474 (19%)
NESP55 <464..632 CDD:115071 44/202 (22%)
WW 815..844 CDD:395320 7/28 (25%)
HECW1_helix 921..987 CDD:408233 3/65 (5%)
WW 993..1024 CDD:197736 2/30 (7%)
HECTc 1222..1576 CDD:238033 110/476 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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