DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Wwc1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_002727807.1	Gene:	Wwc1 / 303039	RGDID:	1308329	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1226	Identity:	218/1226 - (17%)
Similarity:	401/1226 - (32%)	Gaps:	370/1226 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1129 DFDEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKA 1193
            |||  |.::||....:|..|::|                     .|..::.....:|.:.:....
  Rat    17 DFD--GKVYYIDHRNRTTSWIDP---------------------RDRYTKPLTFADCISDELPLG 58

  Fly  1194 W---FAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTAT 1255
            |   :...:|.|.|                          |.:|.|   |.::|..:
  Rat    59 WEEAYDPQVGDYFI--------------------------DHNTKT---TQIEDPRV-------- 86

  Fly  1256 WPINCATDDSVWYR--------HIRIQQNGRNASGQTHYLSLSGFEI---------------YGR 1297
                      .|.|        ::.:.|...:|..:.:.:.....|:               .|.
  Rat    87 ----------QWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGS 141

  Fly  1298 VVGVADDIGKSVKE---------AEAKTR-----RERRQIRAQLKHMTTGARVIRGVDWRWEEQD 1348
            .|.:......|.|.         |.||:|     ||...::.:|:....|.:.::.:|.|..:..
  Rat   142 QVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDERMSDAQ 206

  Fly  1349 GCAEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDL-----KLAD---CEYLSAFDGNQSMGS 1405
            |   |....|......:.|   .::.:...|.:.|.||     .|.|   .:..|..|...|..|
  Rat   207 G---GYKLDEAQAVLRETK---AIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSS 265

  Fly  1406 ASTAAKPSEKGGNTLTSR-------KSSSTPSLPEATEKNQNPEGASN-------QTVSADNLAW 1456
            ..:::.|..|....::|:       .:||:..|.|........|.|..       |....|:.||
  Rat   266 LESSSFPVPKQFLDVSSQTDISGSFSTSSSNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAW 330

  Fly  1457 KQTVETIAEN-VFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKD--------------- 1505
            ...:::..:. :..:.|.:::.....::.....:...:..|....::.||
  Rat   331 PGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTER 395

  Fly  1506 ---NISGPSPLSRELEHI--------SDLSAINNSMPAINS-SNVSDLATISENLSLTELSKENI 1558
               | |..:.|.||||..        |.|.::::||.:::| |:...|.:...:|:.:.|.....
  Rat   396 LKLN-SKRNQLVRELEEATRQVAALHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTS 459

  Fly  1559 CRVLTPSYKPAESVTASQSSS------------HPDVQSSSPRENDIKNISNIEENNKMNANNSV 1611
            .......|.|.|.:.:...|.            .|....::..|:::......|..:::.|..|:
  Rat   460 ASFTDLYYDPFEQLDSELPSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRLQALRSL 524

  Fly  1612 NKISKDLLA-NLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVP 1675
            :...:.:.: :.|:|..:..||.:.|                    :::.:|:.|.|     ..|
  Rat   525 SGTPRSMTSLSPRSSLSSPSPPCSPL--------------------IADPLLAGDAF-----LTP 564

  Fly  1676 VGGKKTPKAQAL----INPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIK--- 1733
            :..:.|..:..|    :..|.|.::..:           ::|....||..|..:|.....:|
  Rat   565 LEFEDTELSPTLCELSLGTDGARERFRL-----------EEPGPEGKPLGQAASVAPGCGLKVAC 618

  Fly  1734 -EQPISNENVSVPSQM-SISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDN 1796
             ...:|:|:|:..|.: ..|:..|.|:.|:...|....|  .|:.:...|:.....|:...|...
  Rat   619 VSAAVSDESVAGDSGVYEASMQRLGTSEAAAFDSDESEA--VGVTQVQIALKYDEKSKQFAILVI 681

  Fly  1797 QIMNAEANVNEHGDQNASGSFLGHSVTSLVKLAL-----SSN--FHSGLLSTAQSYPSLSSNNSE 1854
            |:.|..|.:.:. ||..:           :::|:     ||.  |.:..|.:|.   ||..|.:.
  Rat   682 QLSNLSALLLQQ-DQKVN-----------IRVAILPCSESSTCLFRTRPLDSAD---SLVFNEAF 731

  Fly  1855 NIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLD-------- 1911
            .::.|.|   :..|::......|...|.|.......|:||   .|.||:    |:..
  Rat   732 WVSMSYP---ALHQKTLRVDVCTTDRSHTEECLGGAQISL---AEVCRS----GERSTRWYNLLS 786

  Fly  1912 ----DEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFV 1972
                .:...:....|....|..:.|...|.|..|..       ::..|.|....|...||
  Rat   787 YKYLKKQGREPQPAEAPGPDHVDAVSALLEQTAVEL-------EKRQEGRSSSQTLEGSW----- 839

  Fly  1973 LKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGI 2037
                              |...:.|:.|  .:..|..:.::.|     |:.:...|: .|.....
  Rat   840 ------------------TYEEEASENE--AVAEEEEREEEEG-----EEDVFAEKV-SPEAEEC 878

  Fly  2038 PEVEIDL-SNTDW-----TIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLE 2096
            |.:::|. :|||.     |:.|              .|.|::..|:       ..|..:.:|.:.
  Rat   879 PALKVDRETNTDSVTPSPTVVR--------------PKDRRVGAPS-------PGPFLRGNTIIR 922

  Fly  2097 SEEF---PQTPDV----SSKSGASTLSPNSPMHIGFNVADNNL--CSV-----DDVLELLTQ--I 2145
            |:.|   ||:..|    .|.|.:||||...|.      ..|:|  .||     ..|..|.|:  |
  Rat   923 SKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPF------VRNSLERRSVRMKRPSSVKSLRTERLI 981

  Fly  2146 NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASN----ALPNW 2197
            ......|:|........|.|::::.:.|::...|:|        |.|    .||.|
  Rat   982 RTSLDLELDLQATRTWHSQLTQEISVLKELKEHLEQ--------AKNHGEKELPQW 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	17/150 (11%)
		MIB_HERC2	1333..1389	CDD:310955	11/60 (18%)
		DamX	1576..>1725	CDD:330571	23/165 (14%)
		HECTc	2265..2725	CDD:238033
Wwc1	XP_002727807.1	WW	9..39	CDD:238122	9/44 (20%)
		WW	55..84	CDD:278809	8/57 (14%)
		ALDH-SF	378..>420	CDD:299846	9/42 (21%)
		C2_Kibra	661..784	CDD:176062	30/147 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900